Red cell distribution width as a novel predictor for clinical outcomes in patients with paroxysmal atrial fibrillation

Lee, Ki Hong; Park, Hyung Wook; Cho, Jeong Gwan; Yoon, Nam Sik; Kim, Sung Soo; Kim, Mi Ran; Kim, Min Chul; Cho, Kyung Hoon; Kim, Hyun Kuk; Kim, Cheol Hwan; Kim, Kyung Hwan; Jun, Seung Jin; Kim, Woo Jin; Lee, Kyung Jin; Jeong, Hae Chang; Cho, Jae Yeong; Park, Keun-Ho; Sim, Doo Sun; Yoon, Hyun Ju; Kim, Kye Hun; Hong, Young Joon; Kim, Ju Han; Ahn, Youngkeun; Jeong, Myung Ho; Park, Jong Chun

doi:10.1093/europace/euv210

Cited by 34 publications

(28 citation statements)

References 16 publications

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“…There are multiple other factors, such as vascular damage caused by stent placement, local and systemic inflammatory responses induced by stent implantation and of coronary lesion severity, that may also affect stent restenosis. The red cell distribution width (RDW), which is commonly used to evaluate anaemia, has emerged as a new cardiovascular prognostic marker, and increased RDW values have been shown in patients with heart failure,8 coronary events,9 10 paroxysmal atrial fibrillation11 and end-organ damage with systolic-diastolic hypertension 12. In this retrospective study, we analysed the RDW, clinical features, serological indexes and coronary angiography results to determine the risk factors for ISR and provided a theoretical basis for preventive stent restenosis treatment after PCI.…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids

Qian

Luo

Xiao

et al. 2018

Postgraduate Medical Journal

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BackgroundRed cell distribution width (RDW) is associated with a poor prognosis and adverse events in cardiovascular diseases. The aims of this study were to investigate the relationship between serum RDW levels and outcomes after percutaneous coronary intervention and to identify potential novel laboratory markers for evaluating the risk of in-stent restenosis (ISR) with stable angina pectoris.MethodsA total of 261 patients with coronary heart disease from Dongfeng General Hospital implanted with a coronary drug-eluting stent (DES) were enrolled in the study. We retrospectively analysed the role and prognosis values of serum parameters that were measured before angiography at the first admission. According to the results of the second angiogram, the patients were divided into two groups as follows: the non-ISR group (n=143) and the ISR group (n=118). The clinical characteristics and all laboratory data were considered for univariate and multivariate logistic regression analyses.ResultsThe white cell count, RDW, neutrophil count, C-reactive protein (CRP), total cholesterol, low-density lipoprotein cholesterol (LDL-C), blood urea nitrogen and uric acid levels were higher in the ISR group than in the non-ISR group. There were no differences in the rates of hypertension, fasting plasma glucose, red cell count, neutrophil to lymphocyte ratio, platelet count, triglyceride, high-density lipoprotein cholesterol and creatinine levels. In the univariate regression analysis, age, diabetes, white cell count, neutrophil count, RDW, CRP, total cholesterol, LDL-C, blood urea nitrogen, Gensini score and number of stents were predictors of ISR. According to the multiple logistic regression analysis, age, RDW and number of stents were independent predictors of ISR.ConclusionsPreprocedural blood parameters can independently predict ISR. Our study results demonstrated that a high preprocedural RDW is an independent predictor of DES restenosis.

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Section: Introductionmentioning

confidence: 99%

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids

Qian

Luo

Xiao

et al. 2018

Postgraduate Medical Journal

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“…Recently, a series of clinical experiments have revealed that an increased RDW is an independent predictive factor of poor prognosis for cardiovascular diseases, such as cardiac failure, coronary heart disease and AF [21,22,23,24,25,26]. Kurt et al [14] discovered that high RDW is an independent predictive factor for a high CHA 2 DS 2 -VASc score, while Lee et al [13] found that the CHA 2 DS 2 -VASc score and the occurrence rate of ischemic stroke increase with an increase in RDW. It can be seen that high RDW is associated with an increased risk of AF embolism.…”

Section: Discussionmentioning

confidence: 99%

“…At present, there has been little relevant research on RDW and the risk of bleeding for AF patients when taking anticoagulants. Though Lee et al [13] indicated in their research that the occurrence rate of bleeding events increased with the increase in RDW, they did not mention the specific anticoagulant used. …”

Section: Discussionmentioning

confidence: 99%

“…Red blood cell distribution width (RDW) mainly reflects the heterogeneity of the volume of red blood cells [11]. There are studies demonstrating that RDW is related to the genesis and prognosis of AF [12,13]. Some factors, such as age, hypertension and stroke, can be treated as predictors for evaluating the risks of thromboembolism and bleeding in patients with AF [2].…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of Red Blood Cell Distribution Width on Bleeding Events in Nonvalvular Atrial Fibrillation Patients Taking Dabigatran (110 mg b.i.d.) after Catheter Ablation

et al. 2016

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Objectives: Recent research has indicated that red blood cell distribution width (RDW) is associated with the prognosis of cardiovascular diseases such as chronic heart failure and coronary heart disease. We aimed to study the predictive value of RDW for bleeding events in patients with nonvalvular atrial fibrillation (NVAF) during the administration of 110 mg of dabigatran twice a day after catheter ablation. Methods: One hundred and seventy-two NVAF patients who were hospitalized and received catheter ablation in Jiangsu Provincial People's Hospital from January 2014 to January 2015 were enrolled (110 mg of dabigatran was administered orally to outpatients preoperatively twice a day for 3 weeks). The enrolled patients were divided into the high RDW (>12.8%) group (n = 85) and the low RDW (≤12.8%) group (n = 87) according to the median RDW. The activated partial thromboplastin time (APTT) at dabigatran trough concentration was also detected. Patients were followed up for 3 months to observe the occurrence of bleeding events, and the predictive value of RDW as well as APTT for bleeding events was assessed from receiver-operating characteristic (ROC) analyses. Results: In all patients, preoperatively, no bleeding events were observed and the APTT did not exceed twice the normal upper limit. Thirteen cases of bleeding events, all minor bleeding, occurred after a 3-month follow-up: 3 of gingival bleeding, 3 of urinary tract bleeding, 3 conjunctival hemorrhages and 4 subcutaneous hemorrhages. The incidence of bleeding events in the low RDW group was lower than in the high RDW group (3.4 vs. 11.8%, p = 0.039). The areas under the ROC curve for RDW and APTT to predict the occurrence of bleeding events were 0.737 (cutoff point 13.25%; p < 0.05) and 0.558 (p > 0.05), respectively. Conclusion: RDW was associated with the occurrence of bleeding events in NVAF patients on dabigatran (110 mg twice a day) after ablation, while also being an independent predictor of bleeding events. RDW had superior predictive value for bleeding events over APTT when APTT did not exceed twice the normal upper limit.

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“…Thus, the management of AF is very important, especially in terms of preventing thromboembolic events. Recently, studies have reported that a high red blood cell distribution width (RDW) is associated with a poor prognosis and bleeding events in patients with AF [3,4]. …”

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confidence: 99%

Red Cell Distribution Width and Hemorrhagic Events Related to Dabigatran Use

Altıparmak

Beşli²

2016

Cardiology

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Red cell distribution width as a novel predictor for clinical outcomes in patients with paroxysmal atrial fibrillation

Abstract: RDW can be a new, useful, novel predictor of clinical and safety outcomes in patients with paroxysmal AF.

Cited by 34 publications

References 16 publications

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids

Prognostic Value of Red Blood Cell Distribution Width on Bleeding Events in Nonvalvular Atrial Fibrillation Patients Taking Dabigatran (110 mg b.i.d.) after Catheter Ablation

Red Cell Distribution Width and Hemorrhagic Events Related to Dabigatran Use

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