Red cell distribution width and in‐hospital mortality in septic shock: A public database research

Ding, Qiong; Su, Yingjie; Li, Changluo; Ding, Ning

doi:10.1111/ijlh.13925

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…The relationship between delta serum phosphate level and 28-day mortality was non-linear with a point of inflection at − 0.3 mg/dL. In recent years, a series of risk factors have been identified as predictors of death from septic shock, including old age, serum lactate level, red blood cell distribution width, blood urea nitrogen level, creatinine level, and SOFA score [25][26][27][28][29][30] . Despite the development of therapeutic agents and strategies for treating septic shock, the mortality rate remains consistently high among critically ill patients 4,[31][32][33][34] .…”

Section: Discussionmentioning

confidence: 99%

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Nan,

Huang,

Wan

et al. 2023

Sci Rep

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This study aimed to investigate the relationship between serum phosphate levels, changes in serum phosphate levels, and 28-day mortality in patients with septic shock. In this retrospective study, data were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database between 2008 and 2019. Patients were divided into three groups according to the tertiles of serum phosphate levels. Kaplan–Meier curves and log-rank test analyses were used for survival analysis. Multivariate logistic regression, and restricted cubic spline (RCS) curve were used to explore the association between serum phosphate, delta serum phosphate levels and 28-day mortality. In total, 3296 patients with septic shock were included in the study, and the 28-day mortality was 30.0%. Serum phosphate levels were significantly higher in the non-survivor group than in the survivor group. The Kaplan–Meier curves showed significant differences among the three groups. Multivariate logistic regression analysis and the RCS curve showed that serum phosphate levels were independently and positively associated with the 28-day mortality of septic shock. Non-survivors had higher delta serum phosphate levels than survivors. Survival analysis showed that patients with higher delta serum phosphate levels had higher 28-day mortality. A non-linear relationship was detected between delta serum phosphate and 28-day mortality with a point of inflection at − 0.3 mg/dL. Serum phosphate levels were positively and independently associated with 28-day mortality in septic shock. Delta serum phosphate level was a high-risk factor for patients with septic shock.

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Section: Discussionmentioning

confidence: 99%

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Nan,

Huang,

Wan

et al. 2023

Sci Rep

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show abstract

“…This retrospective study was performed on the basis of the data from the Medical Information Mart for Intensive Care IV(MIMIC-IV) database ( https://mimic.mit.edu/iv/ ). MIMIC-IV is a U.S. public database and contains the clinical information of critical ill patients admitted in intensive care unit (ICU) of Beth Israel Deaconess Medical Center of Boston between 2008 and 2019 15 – 17 . The corresponding author (N.D.) passed the Protecting Human Research Participants exam (No.32900964) and had the permission for utilizing the MIMIC-IV database.…”

Section: Methodsmentioning

confidence: 99%

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

Guo

et al. 2023

Sci Rep

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This study aimed to investigate the relationship between serum ferritin level and prognosis in sepsis. It also explored the potential prognostic value of serum ferritin for predicting outcomes in sepsis based on a large public database. Sepsis patients in MIMIC-IV database were included. Different models including crude model (adjusted for none), model I (adjusted for age and gender) and model II (adjusted for all potential confounders) were performed. Smooth fitting curves were constructed for exploring the relationships between serum ferritin and mortalities of 28-day, 90-day, 180-day and 1-year. Receiver operator characteristic (ROC) curve analysis was utilized for assessing the predictive value of serum ferritin. 1947 sepsis patients were included. The mortalities of 28-day, 90-day, 180-day and 1-year were 20.18% (n = 393), 28.35% (n = 552), 30.30% (n = 590) and 31.54% (n = 614), respectively. In Model II (adjusted for all potential confounders), for every 1000 ng/ml increment in serum ferritin, the values of OR in mortalities of in 28-day, 90-day, 180-day and 1-year were 1.13 (95% CI 1.07–1.19, P < 0.0001), 1.15 (95% CI 1.09–1.21, P < 0.0001), 1.16 (95% CI 1.10–1.22, P < 0.0001) and 1.17 (95% CI 1.10–1.23, P < 0.0001), respectively. The relationships between serum ferritin level and outcomes were non-linear. The areas under the ROC curve (AUC) of ferritin for predicting mortalities of 28-day, 90-day, 180-day and 1-year were 0.597 (95% CI 0.563–0.629), 0.593 (95% CI 0.564–0.621), 0.595 (95% CI 0.567–0.623) and 0.592 (95% CI 0.564–0.620), respectively. The non-linear relationships between serum ferritin and clinical outcomes in sepsis were found. Serum ferritin had a predictive value for short-term and long-term outcomes in sepsis.

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“…It might be a helpful predictor for septic shock patients’ clinical outcomes. 51 Similarly, albumin level was associated with sepsis’s short- and long-term outcomes. Albumin supplementation might benefit septic patients with serum albumin <2.6 g/dL.…”

Section: Discussionmentioning

confidence: 99%

The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study

Tan,

Li,

Huang

et al. 2024

JIR

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Objective To explore the relationship between red blood cell distribution width to albumin (RDW/ALB) ratio (RAR) and the risk of rehospitalization and rehospitalization all-cause mortality in middle-aged and elderly survivors with sepsis based on an ambispective longitudinal cohort from the Intensive Care Unit (ICU). Methods Between 2017 and 2022, 455 adults who survived the first-episode severe sepsis without recurrence for at least 3 months were included in this study. All participants were followed up every 4 weeks for 12 months. According to the tertiles of RAR, participants were divided into three groups: low-level (≤0.36, n = 152), moderate-level (0.37–0.44, n = 152), and high-level (≥0.45, n = 151). The relationship between RAR and the risk of rehospitalization and rehospitalization all-cause mortality was evaluated. Results Out of 455 participants, 156 experienced rehospitalization (34.3%), of which 44 (28.2%) died. Receiver operating characteristic (ROC) analysis showed that the RAR cut-off values for rehospitalization and rehospitalization all-cause mortality were 0.4251 and 0.4743, respectively. Multivariate Cox regression analysis indicated that the RAR was positively associated with rehospitalization ( P = 0.011) and all-cause mortality ( P = 0.006). Compared with the low-level, the high-level RAR presented a higher dose-dependent rehospitalization risk ( P = 0.02) and rehospitalization all-cause mortality ( P = 0.044). The stratified analysis displayed that compared to the low-level, with the RAR increasing by 1.0, the risk for rehospitalization increased 3.602-fold in aged <65 patients ( P = 0.002) and 1.721-fold in female patients ( P = 0.014). Kaplan–Meier survival analysis implied a significant positive association between the RAR and the cumulative incidence of rehospitalization and rehospitalization all-cause mortality (log-rank, all P < 0.001). Conclusion RAR has a reliable predictive value for the risk of rehospitalization and rehospitalization all-cause mortality in patients with sepsis. Consequently, monitoring RAR for at least 1 year after surviving sepsis in female patients aged <65 in clinical practice is critical.

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Red cell distribution width and in‐hospital mortality in septic shock: A public database research

Cited by 7 publications

References 45 publications

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study

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