Red Cell Deformability

Dormandy, J. A.

doi:10.1159/000115607

Cited by 18 publications

(8 citation statements)

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“…its pro tein components, can influence RCD [3,20]. Our results suggest that plasma alterations partly counteract the intrinsic loss of RCD and may explain the differences between the groups which were being studied.…”

Section: Discussionmentioning

confidence: 81%

“…Increased red cell turnover [3], causing a fall in the number of old, rigid erythrocytes [ 19], could explain this unexpected finding.…”

Section: Discussionmentioning

confidence: 99%

“…Red cell deformability (RCD), one of the factors that determine blood fluidity, seems to be worth studying in normal pregnancy because of the close rela tionship recognized between maternal RCD and fetal birth weight [2]. A fall in RCD leads to shortened eryth rocyte lifespan and elevated whole blood viscosity as well as directly resulting in a diminished microcircula tion because of the larger diameter of red cells than of capillaries [3]. The impaired circulation during preg nancy obviously affects placental and therefore fetal blood supply.…”

Section: Introductionmentioning

confidence: 99%

“…RCD is determinated by the cell condition itself [9] as well as markedly affected by changes of plasma compo sition [3] which can be assessed by suspending the eryth rocytes in either buffer or in the original plasma. The purpose of this study was to examine RCD in a normal nonpregnant and late-pregnant population and to evaluate the possible contribution of plasma in its modification.…”

Section: Introductionmentioning

confidence: 99%

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Red Cell Deformability Alterations in Normal Late Pregnancy: Possible Role of Plasma Components

Tamás

Gresele²,

Kett

et al. 1991

Gynecol Obstet Invest

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Red cell deformability of 30 nonpregnant volunteers and 20 normal pregnant women in the 3rd trimester was assessed by determination of filterability of red cells suspended either in autologous plasma or in buffer by St. George’s nitrometer method. Total red cell deformability was decreased in normal pregnancy [transit time (Tc) = 7.79 ± 0.86 vs. 6.99 ± 0.65, p < 0.01] as compared to nonpregnant women when erythrocytes were studied in buffer suspensions, while the number of profoundly rigid red cells was lower in pregnant patients [clogging particles (CP) = 0.864 ± 0.225 vs. 1.103 ± 0.246, p < 0.01]. Total red cell deformability was no longer reduced in pregnant women when erythrocytes were suspended in autologous plasma (Tc = 7.25 ± 0.66 vs. 7.13 ± 0.69, p = NS) while the number of rigid erythrocytes was still lower (CP = 0.802 ± 0.157 vs. 1.055 ± 0.210, p < 0.01). Our data suggest that by the end of normal pregnancy, red cell deformability decreases with a consequent accelerated turnover and a fast elimination of very poorly deformable erythrocytes; plasma alterations in late pregnancy partly counteract the intrinsic loss of deformability of red blood cells.

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Section: Discussionmentioning

confidence: 81%

“…Increased red cell turnover [3], causing a fall in the number of old, rigid erythrocytes [ 19], could explain this unexpected finding.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Red Cell Deformability Alterations in Normal Late Pregnancy: Possible Role of Plasma Components

Tamás

Gresele²,

Kett

et al. 1991

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Red blood cell deformability is determined by intracellular viscosity, membrane viscosity and elasticity, surface area to cell volume ratio, and cell morphology. Red blood cell aggregation depends on cellular (cell morphology, deformability, properties of the cell surface glycocalyx) and plasmatic (fibrinogen and other protein levels) factors, besides the shear forces [28,[31][32][33][34]38]. In addition to these factors, hormonal and metabolic aspects may also affect blood rheology [39].…”

Section: Discussionmentioning

confidence: 99%

Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl:WI) rats

Somogyi

Pető

Deák

et al. 2018

BIR

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Abstract. BACKGROUND:Age-and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. OBJECTIVE: We aimed to investigate the influence of aging and gender on hemorheological parameters in rats. METHODS: Coeval male (n = 10) and female (n = 10) Wistar (Crl:WI) rats were followed-up over 15 months. Blood samples were obtained from the lateral tail vein at 3, 4, 5, 9, 12, 15 and 18 months of age. Hematological parameters, red blood cell deformability (elongation under shear), osmotic gradient deformability and erythrocyte aggregation were tested. Body weight and the estrus cycle (in females) were also examined. RESULTS: Erythrocyte aggregation showed age-and gender-related variations. Red blood cell deformability was greater in females and gradually decreased over the 15-month period in both genders. Erythrocyte aggregation was greater in male rats at most ages, but did not show consistent changes with age. CONCLUSIONS: The micro-rheological parameters showed age-related alterations with gender differences. The effect of the estrous cycle cannot be excluded in female rats. The results provide reference data for studies of aging in rats and of the mechanism related to age and gender differences in hemorheology.

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