Red Cell and Plasma Volume in Newborn Infants

Mollison, P. L.; Veall, N.; Cutbush, Marie

doi:10.1136/adc.25.123.242

Cited by 179 publications

(56 citation statements)

References 12 publications

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“…The mean RCV in our patients, 35.7 ml/kg soon after birth and 21.6 ml/kg at 6 wk, is similar to the results previously reported for newborn infants (1,4,5,7,8,10,11).…”

Section: Discussionsupporting

confidence: 79%

Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants

et al. 2013

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ArticlesClinical Investigation nature publishing group background: Little is known about the change in circulating red cell volume (RCV) of very-low-birth-weight (VLBW) infants during the first weeks of life. Methods: RCV was measured during the first 5 d in 35 VLBW infants using chromium-51 labeling of the infants' red blood cells (RBCs). RCV was measured again at 6 wk of age in 12 infants, and the volumes of RBCs lost by phlebotomy and those gained by transfusion were recorded between the RCV measurements. In six infants, the volume of waste blood on materials contaminated with blood during phlebotomy, which would usually be discarded, was measured by radioactive counting. results: The mean RCV in the first several days of life was 39.6 ml (35.7 ml/kg; range: 20.1-58.7 ml/kg). Of the 12 infants whose RCV was measured twice, all but one had a decrease in absolute RCV. The mean RCV initially and at 6 wk were 37.3 and 26.6 ml, respectively. The mean volume of RBCs lost through phlebotomy was 29.2 ml, and the mean volume of RBCs given by transfusion was 34.5 ml. conclusion: During the first 6 wk of life, when the anemia of prematurity is evolving, the RCV falls despite complete replacement of RBCs lost by diagnostic phlebotomy with transfused RBCs.

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“…The mean RCV in our patients, 35.7 ml/kg soon after birth and 21.6 ml/kg at 6 wk, is similar to the results previously reported for newborn infants (1,4,5,7,8,10,11).…”

Section: Discussionsupporting

confidence: 79%

Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants

et al. 2013

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“…Examination of our data suggested that circulating RBC volume deviated positively from the regression line at HCT values greater than 45. Such a biphasic relationship between circulating RBC volume and HCT has been reported previously in infants (19,20) and adults (21).…”

Section: Resultsmentioning

confidence: 78%

Hematocrit Correlates Well with Circulating Red Blood Cell Volume in Very Low Birth Weight Infants

et al. 2001

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Although circulating red blood cell (RBC) volume is a better measure of total body oxygen delivering capacity than hematocrit (HCT), circulating RBC volume is more difficult to measure. Thus, the HCT is often used in RBC transfusion decisions. However, several previous studies of low birth weight infants have reported that the correlation between HCT and circulating RBC volume is poor. Using a robust nonradioactive method based on in vivo dilution of biotinylated RBC enumerated by flow cytometry, the present study reexamined the correlation between HCT and circulating RBC volume in very low birth weight infants. Venous and capillary HCT levels were compared with circulating RBC volume measured using the biotin method. Twenty-six stable very low birth weight infants with birth weights less than 1300 g were studied on 43 occasions between 7 and 79 d of life. Venous HCT values correlated highly with circulating RBC volume (r ϭ 0.907; p Ͻ 0.0001). However, the mean 95% confidence limits for prediction of circulating RBC volume from venous HCT (the average error of prediction) was Ϯ13.4 mL/kg. The correlation between HCT and circulating RBC volume is strong in older stable very low birth weight infants. However, clinically important uncertainty exists in estimating circulating RBC volume and the associated RBC transfusion needs of an individual infant based on venous HCT. Intensive care of critically ill newborn infants has increased blood sampling and exacerbated the severity of neonatal anemia. Daily phlebotomy blood losses of 4 to 5% of the total blood volume are common among VLBW infants (1-3) who are defined here as those infants with birth weight less than 1500 g. Not surprisingly, the majority of the multiple RBC transfusions such infants receive are administered during the first weeks of life when phlebotomy loss is greatest (1, 2, 4, 5). The present consensus is that phlebotomy loss from clinical monitoring is the primary cause of the relatively large transfusion needs of VLBW infants (1, 3, 6, 7).The decision to administer a RBC transfusion is typically made on the basis of the infant's clinical condition and the whole blood HCT or blood Hb concentration (3,6,8). Although circulating RBC volume is a more accurate indicator of total body oxygen delivery capacity than whole blood HCT or Hb concentration (9, 10), HCT and Hb concentration are used clinically because they are quick, inexpensive, and analytically reliable. To understand the limitations of HCT as a guide to transfusion decisions, the relationship between HCT and circulating RBC volume in VLBW infants should be elucidated, and the sources of the previously reported poor correlation (9 -14) should be segregated into methodologic artifacts and genuine characteristics of preterm physiology.The aim of the present study was to examine the relationship between HCT and circulating RBC volume in stable VLBW infants. An accurate nonradioactive method based on biotinylated RBC was used to measure circulating RBC volume. ABSTRACT 525

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“…Blood Volume of Newborn There are several reports on total blood-volume determinations in neonates (Schiucking, 1879;Lucas and Dearing, 1921 ;Bakwin and Rivkin, 1924;Robinow and Hamilton, 1940;Brines et al, 1941 ;DeMarsh et al, 1942;Mollison et al, 1950 Budin (1875Budin ( , 1876 and Schiucking (1877) observed that about 100 ml. of blood flowed from the placenta to the infant after birth.…”

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confidence: 99%

Effects of Early and Late Clamping of Umbilical Cord on Infantʼs Haemoglobin Level

Lanzkowsky¹

1961

Obstetrical & Gynecological Survey

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An experiment in helping mentally handicapped men, women, and young people to lead normal working lives is to begin shortly in Northern Ireland. Twelve women and girls, aged 18 and over, will be taken out of special institutions, jobs will be found for them, and they will live in the ordinary community surroundings in a small hostel. The hostel will be in charge of a warden, who will be available to discuss personal problems that arise. The women and girls going into the first hostel are being transferred from special-care centres, where they have received expert training, and they will go out to work each day in the normal way. Some of them will work in local hospitals in the kitchens and laundries, and others may be placed in jobs with outside firms. If this experiment succeeds there will later be separate hostels for men.

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Red Cell and Plasma Volume in Newborn Infants

Cited by 179 publications

References 12 publications

Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants

Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants

Hematocrit Correlates Well with Circulating Red Blood Cell Volume in Very Low Birth Weight Infants

Effects of Early and Late Clamping of Umbilical Cord on Infantʼs Haemoglobin Level

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