Red-cell alloimmunization profile in multi transfused patients: Findings and insights of a blood transfusion service

Bueno, Maura Lima Pereira; Mitestainer, M.B.; Silva, J.A.R. Da; Benites, Bruno Deltreggia; Roversi, Fernanda Marconi

doi:10.1016/j.tracli.2021.04.006

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…During blood transfusion therapy, the occurrence of antigenic mismatch between donors and recipients can pose risks by triggering the production of antibodies against one or more erythrocyte antigens, leading to alloimmunization [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-D Alloimmunization Following Rhesus-Incompatible Platelet Transfusion in a Myelodysplastic Syndrome Patient

Hanafi,

Zulkeflee,

Hassan

et al. 2024

Cureus

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Patients with myelodysplastic syndrome (MDS) often need platelet transfusions to address thrombocytopenia. The risk of alloimmunization, particularly in Rhesus (Rh) incompatibility between donors and recipients during platelet transfusions, is heightened, especially with whole blood-derived pooled platelets as opposed to apheresis platelets. Although the occurrence of alloimmunization from platelet transfusions is minimal, there is an ongoing debate about whether Rh immune globulin (RhIg) should be administered to Rhesus D (RhD)-negative recipients of RhD-positive platelet units. We present a unique case of anti-D alloimmunization in a 56-year-old patient with underlying MDS following multiple platelet transfusions but never received packed cell transfusion or anti-D immunoglobulin. Some studies advocate for RhIg administration in specific scenarios and for certain patient populations. This case underscores the importance of considering Rhesus compatibility or administering anti-D immunoglobulin in cases where frequent platelet transfusions are required.

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Section: Discussionmentioning

confidence: 99%

Anti-D Alloimmunization Following Rhesus-Incompatible Platelet Transfusion in a Myelodysplastic Syndrome Patient

Hanafi,

Zulkeflee,

Hassan

et al. 2024

Cureus

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“…This is supported by a study published by Makarovska Bojadžijeva in 2017, where the presence of anti-E antibodies in combination with other antibodies was proven in more than 50% of detected combined antierythrocyte antibodies ( 15 ). Perreira Bueno et al in 2021, studied the sample of 29,128 tested patients and found the presence of multiple antibodies in 25,32 cases, where the dominant was also anti-E antibody ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Significance of Detecting Antierythrocyte Antibodies in Pretransfusion Testing

Lackovic,

Custendil,

Zabic

et al. 2023

Acta Inform Med

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Background: Transfusion treatment during life, as well as pregnancy in women, can stimulate the sensitization of the person who received blood, which after the transfusion of blood products can result in the occurrence of moderate to very severe posttransfusion reactions. Objective: The aim of this study was to examine the specificity and frequency of antierythrocyte antibodies during the pretransfusion treatment of patients depending on the gender, to determine the origin of antibodies in patients serum, as well as to examine their clinical significance. Methods: Retrospective analysis of documentation was performed in the Department for Pretransfusion Testing, therapy and distribution of blood products, Polyclinic for Transfusion, UKC Tuzla. Data was analyzed by reviewing the written and electronic documentation from the period of 5 years (2018-2022). Results: A retrospective analysis of 378 procedures for the identification of antierythrocyte antibodies was performed. It was evident that 140 of all detected antibodies belonged to the Rh-system (66.7%), of which 32.4% were anti RhD-antibodies, 20% anti Rh-E, anti Rh-c 7.1%, and in a low percent of anti-C, anti-e and anti-Cw antibodies. Combinations of anti-D and anti-C antibodies showed the highest frequency (34.2%), followed by a combination of anti-E and anti-c antibodies (21%). Conclusion: Pretransfusion testing represents a very important link in the safety of the use of blood. The identification of antierythrocyte antibodies and the use of phenotyped blood products significantly reduces the risk of posttransfusion reactions and facilitates the implementation of the safe blood policy.

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“…Optimal utilization of blood is vital to minimize alloimmunization and the spread of transfusion-transmitted infections. 4 Physicians and surgeons make the majority of transfusion decisions without formal training in TM. The clinician transfusion practices are based on their individual experiences and they are mostly unaware of the error in the transfusion chain.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes and practices of resident doctors and interns on safe blood transfusion practices: a survey-based study

Prakash

Mukherjee

Routray

et al. 2023

Hematology, Transfusion and Cell Therapy

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Red-cell alloimmunization profile in multi transfused patients: Findings and insights of a blood transfusion service

Cited by 4 publications

References 21 publications

Anti-D Alloimmunization Following Rhesus-Incompatible Platelet Transfusion in a Myelodysplastic Syndrome Patient

Anti-D Alloimmunization Following Rhesus-Incompatible Platelet Transfusion in a Myelodysplastic Syndrome Patient

Significance of Detecting Antierythrocyte Antibodies in Pretransfusion Testing

Knowledge, attitudes and practices of resident doctors and interns on safe blood transfusion practices: a survey-based study

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