Red Cell Alloantibodies in Multiple Transfused Thalassaemia Patients

Chaudhari, CN

doi:10.1016/s0377-1237(11)80008-0

Cited by 31 publications

(42 citation statements)

References 18 publications

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“…As seen the reported alloimmunisation rates in thalassemics from other parts of India vary from 3.79-9.48 % [8,13,19]. In our study frequency of alloimmunization and autoimmunization was 8.6 and 1.8 % respectively which is similar to that reported from other centers in our country.…”

Section: Discussionsupporting

confidence: 88%

“…Various studies have reported high prevalence of anti E and anti c in Asian population [5,21,22,26]. Based on this Chaudhari et al [8] proposed that there is heterogeneous distribution of Rh E and c Antigen in Indian population. Papiha [29] had reported R1R1 phenotype frequency to be 50 % in North India to 70 % in Mongoloid population.…”

Section: Discussionmentioning

confidence: 98%

“…The risks of red blood cell (RBC) antigen alloimmunization in thalassemia patients are considerably greater than those in general population as evident from alloimmunization rates of 4-50 % reported in studies from various centers involved in management of these patients [5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Red Blood Cell Antibodies in Thalassemia Patients in Northern India: Risk Factors and Literature Review

Elhence

Solanki

Verma

2014

Indian J Hematol Blood Transfus

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Study of the factors responsible for red cell alloimmunization can help in adopting appropriate strategy to minimize alloimmunization. However data for thalassemia patients from our region is limited. Therefore, a study was conducted to find out the frequency and the factors associated with red cell allo and autoimmunization in thalassemia patients at our center so as to enable us to take appropriate action to reduce alloimmunization. Clinical, demographic, allo and autoantibody and transfusion records of 280 thalassemia patients at our hospital were studied. Patients with and without alloantibodies were compared to find significant differences for age, gender, race, age at start of regular transfusions and splenectomy. Red cell antigen frequencies in thalassemia patients and published antigen frequencies in blood donors from the same center were compared to look antigen differences as a risk factor for alloimmunization. Twenty four thalassemia patients (8.6 %) developed 28 clinically significant alloantibodies. 18 (65 %) of the alloantibodies were of Rh system. The three most common antibodies detected was anti E (11, 39.3 %) followed by anti K (6, 21.4 %) and anti c (10.8 %). Five (1.8 %) of the 280 patients developed autoantibodies. Patient age was found to be significantly higher in alloimmunized patients than in non alloimmunized patients. Red cell antigen frequencies between blood donor and recipient populations were found to be homogenous for most of the relevant RBC antigens. The frequency of red cell alloimmunization in thalassemia patients from our center is moderate. In this setting of red cell phenotype concordant donor-recipient population requirement of extended phenotype matched transfusions may not be cost effective.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

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Red Blood Cell Antibodies in Thalassemia Patients in Northern India: Risk Factors and Literature Review

Elhence

Solanki

Verma

2014

Indian J Hematol Blood Transfus

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“…For instance, R1R1 is the most 74 China common genotype in Indian population followed by R1r, therefore, it can be assumed that the most common alloantibodies among Rh blood group system in patients receiving blood transfusion, would be anti-E and anti-c. This is in accordance with the studies on multitransfused patients at a center in north India in which the most common alloantibodies were anti-E and anti-c in thalassemics 11 and chronic renal failure patients. 12 In contrast to this, in another study on prevalence on alloimmunization in 531 multitransfused patients, it was found that anti-c was the most common antibody with specificity of 38.8% and all of them were present in Dþ recipients.…”

Section: Comparision Of Rh Phenotypes Within Different Populationsupporting

confidence: 91%

Proportion of Rh phenotypes in voluntary blood donors

Sarkar

Philip

Mallhi

et al. 2013

Medical Journal Armed Forces India

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a b s t r a c tBackground: The Rh system is the major blood group system besides ABO system. Even after proper blood grouping and cross matching there is a possibility of alloimmunization and antibody production in the recipients against the Rh or minor blood group antigens like Results: The phenotypic frequencies of Rh blood groups in the studied population were D-92.25%, C-87.55%, E-26.55%, c-51.06% and e-98.42%. Thus 'e' was the most common and E was the least common of all the Rh types. Phenotypically DCCee group was the most common phenotype and dccee was least common type.Conclusion: Determination of Rh phenotypes can play a major role in preventing alloimmunization and avoiding adverse events in multitransfusion cases.ª 2013, Armed Forces Medical Services (AFMS). All rights reserved.

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“…Its prevalence among alloantibodies detected in patients has been reported to range from 3.1 to 17.5 % [3][4][5][6][7][8]. Like most of Rh antibodies, anti-c also belongs to Ig G class of immunoglobulins and is an important cause of hemolytic transfusion reaction, more so in DHTR [9].…”

Section: Discussionmentioning

confidence: 99%