Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats

Abstract

The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

Functional Subtypes of Renal α₁-Adrenoceptor in Spontaneously Hypertensive Rats with Streptozotocin-Induced Experimental Diabetic Nephropathy

“…In this approach the doses of the antagonists used were carefully balanced to both avoid possible systemic effects and cause blockade of renal ␣ 1 -adrenoceptors [5,6,8] . The development of diabetic nephropathy in the rat was confirmed by marked alteration in urinary albumin excretion, hyperfiltration, renal hypertrophy, increased plasma creatinine and fractional excretion of sodium which were comparable to those reported earlier [15,17,[19][20][21] . A number of studies have emphasized that the renal hypertrophy, hyperfiltration and albuminuria are the most significant markers indicating the early phase of diabetic nephropathy both in human and animal models [23,[25][26][27] .…”

“…Diabetic SHR were followed over 28 days with weekly metabolic cage studies to collect physiological data to allow assessment of the development of diabetic nephropathy in terms of urinary albumin excretion, creatinine clearance and fractional excretion of sodium. The presence of diabetic nephropathy was confirmed in the terminal study by the presence of hyperfiltration, albuminuria and renal hypertrophy as reflected by the kidney index [15,17,[19][20][21] . Urinary albumin excretion in 24 h urine collection was measured using an ELISA-based method.…”

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

“…Untreated hyperglycemia very often leads to a number of complications including over-production of ROS such as superoxide anion (O 2 −), nitric oxide (NO-) and hydrogen peroxide (H 2 O 2 ); which in turn damages the beta cells through the induction of apoptosis and the suppression of insulin biosynthesis [47][48][49][50][51][52][53][54]. In-fact, STZ is known to decrease insulin biosynthesis through alkylation of DNA and overproduction of nitric oxide (NO) and other free radicals [55].…”

Ethanol Extract of Purple Sweet Potato Tubers (Ipomoea batatas L) Decreases Blood Glucose and Increase Total Antioxidant Level in Rats with High Glucose Intake

“…MDA level increase was a marker of oxidative stress [14], in rats given high oral glucose load. Total antioxidant level was also decreased in these rats.…”