Red Blood Cells: Their Dual Role in Thrombus Formation

Turitto, Vincent T.; Weiß, H.

doi:10.1126/science.7352265

Cited by 347 publications

(188 citation statements)

References 16 publications

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“…Moreover, decreased hematocrit leads to changes in red blood cell–mediated nitric oxide metabolism, increasing cardiac output 25. Another proposal is that decreased hematocrit activates erythrocyte‐derived adenosine diphosphate, which stimulates platelet activation and increases platelet adhesiveness, thereby elevating the risk of atherosclerosis and thrombosis,27, 28 which can cause ischemic cardiocerebrovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Association Between Changes in Hemoglobin Concentration and Cardiovascular Risks and All‐Cause Mortality Among Young Women

Lee

Choi

Kim

et al. 2018

JAHA

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BackgroundAnemia is considered to increase the risk of mortality in high‐risk populations, but its effect has not been examined among young populations. This study aimed to determine the effect of hemoglobin (Hb) concentration and its changes on the risk of acute myocardial infarction (AMI), stroke, cerebrovascular disease and all‐cause mortality among young women.Methods and ResultsWe analyzed data from the Korean National Health Information Database on 808 143 women aged 20 to 39 years without any cardiocerebrovascular disease. A 1‐time Hb concentration and changes in Hb over a 2‐year period were calculated as exposures. Participants were followed for a median of 10 years to determine the risk of AMI, stroke, cerebrovascular disease, and all‐cause mortality. There were U‐ or J‐shaped associations between Hb concentration or change in Hb and AMI, stroke, cerebrovascular disease, and all‐cause mortality. Increasing the Hb concentration from normal to high increased the risk for AMI (hazard ratio [95% confidence interval]: 1.49 [1.08‐2.04]). With regard to the risk for stroke, increasing the Hb concentration from a normal to a high range increased the risk (hazard ratio [95% confidence interval]: 1.10 [1.02‐1.35]), and decreasing the Hb concentration from a high to a normal range decreased this risk (hazard ratio [95% confidence interval]: 0.80 [0.60‐0.97]). Improving anemia to the normal Hb range decreased all‐cause mortality (hazard ratio [95% confidence interval]: 0.81 [0.69‐0.94]); however, overcorrection of Hb concentration (Hb≥14.0 g/dL) was not significant.ConclusionsThese findings suggest that regular Hb analysis may assist in identifying young women who are at risk of AMI, stroke, cerebrovascular disease, and all‐cause mortality.

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Section: Discussionmentioning

confidence: 99%

Association Between Changes in Hemoglobin Concentration and Cardiovascular Risks and All‐Cause Mortality Among Young Women

Lee

Choi

Kim

et al. 2018

JAHA

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“…Furthermore, elevated hematocrit has been shown to promote the transport of platelets towards the vessel wall, thereby increasing the interaction with the vasculature. 23 Blood clotting is also dependent on the velocity gradient at which the clotting takes place. The influence of the hematocrit on blood viscosity increases when the shear rate decreases.…”

Section: Discussionmentioning

confidence: 99%

Hematocrit and risk of venous thromboembolism in a general population. The Tromso study

Brækkan¹,

Mathiesen²,

Njølstad³

et al. 2009

Haematologica

162

119

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BackgroundHematocrit above the normal range for the population, such as in primary or secondary erythrocytosis, predisposes to both arterial and venous thrombosis. However, little is known about the association between hematocrit and risk of venous thromboembolism in a general population. Design and MethodsHematocrit and related hematologic variables such as hemoglobin, red blood cell count, mean corpuscular volume, and baseline characteristics were measured in 26,108 subjects, who participated in the Tromsø Study in 1994-1995. Incident venous thromboembolic events during follow-up were registered up to September 1 st , 2007. ResultsThere were 447 venous thromboembolic events during a median of 12.5 years of followup. Multivariable hazard ratios per 5% increment of hematocrit for the total population, adjusted for age, body mass index and smoking, were 1.25 (95% CI: 1.08-1.44) for total venous thromboembolism and 1.37 (95% CI: 1.10-1.71) for unprovoked venous thromboembolism. In category-based analyses, men with a hematocrit in the upper 20 th percentile (≥46% in men) had a 1.5-fold increased risk of total venous thromboembolism (95% CI: 1.08-2.21) and a 2.4-fold increased risk of unprovoked venous thromboembolism (95% CI: 1.36-4.15) compared to men whose hematocrit was in the lower 40 th percentile. The risk estimates were higher for men than for women both in continuous and category-based analyses. The findings for hemoglobin and red blood cell count were similar to those for hematocrit, whereas mean corpuscular volume was not associated with venous thromboembolism. ConclusionsOur findings suggest that hematocrit and related hematologic variables such as hemoglobin and red blood cell count are risk factors for venous thromboembolism in a general population.Key words: hematocrit, population range, arterial and venous thrombosis. Study. Haematologica. 2010; 95:270-275. doi:10.3324/haematol.2009 Hematocrit and risk of venous thromboembolism in a general population. The Tromsø study Citation: Braekkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, and Hansen J-B. Hematocrit and risk of venous thromboembolism in a general population. The Tromsø

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“…38 In these two MPNs, there are also RBC abnormalities that include biochemical changes in the cell membrane and content. 39 These changes may independently impair blood flow also through the formation of RBC aggregates that have the potential to directly block blood flow in small vessels, thus contributing to cause ischaemia and infarct, especially in the cerebral blood flow.…”

Section: Erythrocytosis and Red Cell Abnormalitiesmentioning

confidence: 99%

Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation

Landolfi

Gennaro

Falanga³

2008

Leukemia

133

114

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Thrombophilia, which severely impacts on morbidity and mortality of polycythaemia vera and essential thrombocythaemia, is variably characterized by microcirculatory disturbances, arterial and venous thromboses that often precede disease recognition. Thus, the search for Janus Kinase 2 mutation, the molecular marker of myeloproliferative neoplasms, is becoming increasingly common particularly in patients with vein thromboses at atypical sites. Although the pathogenesis of thrombophilia is still elusive, platelet and leukocyte abnormalities seem particularly critical and likely account for the antithrombotic efficacy of aspirin and hydroxyurea.

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Red Blood Cells: Their Dual Role in Thrombus Formation

Cited by 347 publications

References 16 publications

Association Between Changes in Hemoglobin Concentration and Cardiovascular Risks and All‐Cause Mortality Among Young Women

Association Between Changes in Hemoglobin Concentration and Cardiovascular Risks and All‐Cause Mortality Among Young Women

Hematocrit and risk of venous thromboembolism in a general population. The Tromso study

Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation

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