Red blood cells as innovative antigen carrier to induce specific immune tolerance

Cremel, Magali; Guerin, Nathalie; Horand, Françoise; Banz, Alice; Godfrin, Yann

doi:10.1016/j.ijpharm.2012.12.044

Cited by 65 publications

(59 citation statements)

References 37 publications

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“…This non-responsiveness is antigen-specific, with non-responders to the hGPA antigen being fully capable of responding to other distinct RBC antigens. RBC antigen copy number may contribute to whether a particular antigen is capable of inducing an immune response following transfusion, as suggested by studies that have shown antigen density to be a key determinant of immunologic responsiveness to non-RBC antigens [119,120,121]. Although hGPA copy number has not been formally evaluated, flow-cytometric cross-matching of these RBCs with monoclonal anti-hGPA results in a 3-4 log shift and in vitro agglutination, suggesting that the copy number is very high.…”

Section: Recipient Factorsmentioning

confidence: 99%

“…transfusion of RBCs with a secondary intranasal peptide exposure to an immunodominant peptide of an antigen expressed on the RBC surface, the authors were able to decrease the T-cell response [73]. Other murine studies have recently explored the use of RBCs as vehicles to induce tolerance to non-RBC antigens, with antigen-specific tolerance to the OVA antigen observed following immunization with OVA-entrapped RBCs [121]. …”

Section: Recipient Factorsmentioning

confidence: 99%

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Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

Ryder

Zimring

Hendrickson

2014

Transfus Med Hemother

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Red blood cell (RBC) alloimmunization may occur following transfusion or pregnancy/delivery. Although observational human studies have described the immunogenicity of RBC antigens and the clinical significance of RBC alloantibodies, studies of factors influencing RBC alloimmunization in humans are inherently limited by the large number of independent variables involved. This manuscript reviews data generated in murine models that utilize transgenic donor mice, which express RBC-specific model or authentic human blood group antigens. Transfusion of RBCs from such donors into nontransgenic but otherwise genetically identical recipient mice allows for the investigation of individual donor or recipient-specific variables that may impact RBC alloimmunization. Potential donor-related variables include methods of blood product collection, processing and storage, donor-specific characteristics, RBC antigen-specific factors, and others. Potential recipient-related variables include genetic factors (MHC/HLA type and polymorphisms of immunoregulatory genes), immune activation status, phenotype of regulatory immune cell subsets, immune cell functional characteristics, prior antigen exposures, and others. Although murine models are not perfect surrogates for human biology, these models generate phenomenological and mechanistic hypotheses of RBC alloimmunization and lay the groundwork for follow-up human studies. Long-term goals include improving transfusion safety and minimizing the morbidity/mortality associated with RBC alloimmunization.

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Section: Recipient Factorsmentioning

confidence: 99%

Section: Recipient Factorsmentioning

confidence: 99%

Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

Ryder

Zimring

Hendrickson

2014

Transfus Med Hemother

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“…Because sustained immunosuppression increases the risk of infection, an important goal remains the development of antigen-specific immune intervention to achieve tolerance, while sparing desirable effector immune responses, such as those directed against pathogens (1). Administration of soluble, disaggregated proteins or peptides, apoptotic cells, or micro/nanoparticles chemically conjugated with antigenic peptide, as well as antibody fusion constructs, have been used with varying degrees of success (2)(3)(4)(5)(6)(7)(8). A challenge in the development of antigen-specific immune intervention is the delivery of the antigenic payload to the correct destination for processing, to establish long-lasting peripheral tolerance.…”

mentioning

confidence: 99%

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

Pishesha

Bilate

Wibowo

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

130

117

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Significance Immune-mediated diseases are prevalent, debilitating, and costly. Unfortunately, current treatments rely on nonspecific immunosuppression, which also shuts down a protective immune response. To circumvent this, we exploited the noninflammatory natural means of clearance of red blood cells (RBCs), in combination with sortase-mediated RBC surface modification to display disease-associated autoantigens as RBCs’ own antigens. We found that this strategy holds promise for prophylaxis and therapy, as shown in a mouse model of multiple sclerosis and of type 1 diabetes.

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“…Since the concept of erythrocyte immune was advanced, the new domain of immune system of organism was opened up (Cremel et al, 2013). Studys showed red blood cell can adhere to tumor cells by the surface's C3b receptor (C3bR), formed immunocomplex, which could be easily eaten by macrocytes.…”

Section: Discussionmentioning

confidence: 99%

Low-dose Radiation Induces Antitumor Effects and Erythrocyte System Hormesis

Yu¹,

Liu²,

Yu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. Methods: Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental in situ animal model. Six hours before implantation, the mice were given 75mGy whole body X-ray radiation. Tumor growth was observed 5 days later, and the tumor volume was calculated every other day. Fifteen days later, all mice were killed to measure the tumor weight, and to observe necrotic areas and tumor-infiltration-lymphoreticular cells (TILs). At the same time, erythrocyte immune function and the level of 2,3-diphosphoglyceric acid (2,3-DPG) were determined. Immunohistochemical staining was used to detect the expression of EPO and VEGFR of tumor tissues. Results: The mice pre-exposed to low dose radiation had a lower tumor formation rate than those without low dose radiation (P < 0.05). The tumor growth slowed down significantly in mice pre-exposed to low dose radiation; the average tumor weight in mice pre-exposed to low dose radiation was lighter too (P < 0.05). The tumor necrosis areas were larger and TILs were more in the radiation group than those of the group without radiation. The erythrocyte immune function, the level of 2,3-DPG in the low dose radiation group were higher than those of the group without radiation (P < 0.05). After irradiation the expression of EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from sham-irradiation group. The expression of VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function and the ability of carrying O 2 . Low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself.

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Red blood cells as innovative antigen carrier to induce specific immune tolerance

Cited by 65 publications

References 37 publications

Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

Low-dose Radiation Induces Antitumor Effects and Erythrocyte System Hormesis

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