Red blood cell storage time and the outcome after coronary surgery

Kinnunen, Esko; Sabatelli, Ludovico; Juvonen, Tatu; Biancari, Fausto

doi:10.1016/j.jss.2015.03.025

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…This finding is in accordance with previous surprising findings indicating that prolonged storage of blood may be beneficial compared with younger blood [ 19 ], although difficult to explain. In contrast to our findings, an observational study among 819 patients undergoing isolated CABG showed that POAF was significantly more often developed in transfused patients who received blood units all stored for >14 days compared with patients who received blood units all stored for <14 days [ 21 ]. Such different findings may be explained by e.g.…”

Section: Discussioncontrasting

confidence: 99%

“…To our knowledge only one study have reported on the development of POAF following cardiac surgery in relation to transfusion of “older” versus “younger” blood [ 21 ]. The primary aim of the present study was therefore to evaluate whether storage time of transfused RBC is associated with development of POAF in patients undergoing cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

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Storage time of intraoperative transfused allogeneic red blood cells is not associated with new-onset postoperative atrial fibrillation in cardiac surgery

Skals

Torp‐Pedersen

et al. 2017

PLoS ONE

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BackgroundAllogeneic red blood cell (RBC) transfusion has been associated with new-onset postoperative atrial fibrillation (POAF) following cardiac surgery. Prolonged storage time of RBC may increase the risk. The primary aim of the study was to evaluate whether the storage time of RBC is associated with development of POAF.Materials and methodsPre-, per- and postoperative data were retrieved from the Western Denmark Heart Registry and local blood banks regarding patients who underwent coronary artery bypass surgery, valve surgery or combined procedures in Aalborg or Aarhus University Hospital during 2010–2014. Multiple logistic regression was used to determine the risk of POAF according to transfusion of RBC on the day of surgery. Furthermore, we determined trend in storage time of RBC according to risk of POAF using restricted cubic splines. Patients with a history of preoperative atrial fibrillation, patients who received transfusions preoperative and patients who died at the day of surgery were among excluded patients.ResultsA total of 2,978 patients with a mean age of 66.4 years were included and 609 patients (21%) received RBC transfusion on the day of surgery. POAF developed in 752 patients (25%) and transfused patients were at an increased risk compared with non-transfused patients (adjusted Odds Ratios for patients receiving RBC: 1.37; 95% CI: 1.11–1.69, P-value = 0.004). However, RBC transfusion was not necessarily the cause of POAF and may only be a marker for development of POAF. There was no significant association between storage time of RBC and POAF.ConclusionsIn contrast to intraoperative allogeneic RBC transfusion in general, increased storage time of RBC is not associated with development of POAF in cardiac surgery.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Storage time of intraoperative transfused allogeneic red blood cells is not associated with new-onset postoperative atrial fibrillation in cardiac surgery

Skals

Torp‐Pedersen

et al. 2017

PLoS ONE

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“…, Kinnunen et al . ). In trauma patients, evidence suggests that administration of older packed red cell units increases the risk for bacterial infections (Offner et al .…”

Section: Discussionmentioning

confidence: 97%

Biochemical evaluation of the effects of storage on feline erythrocytes

Heinz

Pashmakova

Wilson

et al. 2016

J of Small Animal Practice

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“…12 The observational and RCT studies do not have a definitive and biologically determined threshold for what constitutes a fresh versus old RBC unit. Some studies use 7 days, 12 8 days, 10 10 days, 13 14 days, 4,14,15 18 days, 16 or 21 days, 6,17 and some leave gaps between the definition of fresh versus old RBC units. 11,18 These choices are not only arbitrary, but make the assumption that stored RBCs undergo a linear decay process.…”

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confidence: 99%