Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

Passos, Andreas; Louka, Marinos; Vryonidis, Charalambos; Inglezakis, Antonis; Loizou, Konstantinos; Nikiphorou, Elena; Psarelis, Savvas; Kaliviotis, Efstathios

doi:10.3233/ch-221476

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Elevated levels of CRP and ESR are associated with higher disease activity and consequently more joint damage (76,78). "CRP is an acute-phase protein that is synthesized by the liver in response (82)(83)(84)(85). A high degree of inflammation, as observed in RA (26,32), causes red blood cells to aggregate more, which makes them sediment faster and thereby increasing the ESR (82).…”

Section: Blood Biomarkersmentioning

confidence: 99%

Molecular Profiling of Inflammatory Arthritis

Aboo

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Section: Blood Biomarkersmentioning

confidence: 99%

Molecular Profiling of Inflammatory Arthritis

Aboo

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Early stage of erythrocyte sedimentation rate test: Fracture of a high-volume-fraction gel

John,

Kaestner,

Wagner

et al. 2023

PNAS Nexus

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Erythrocyte sedimentation rate (ESR) is a clinical parameter used as a nonspecific marker for inflammation, and recent studies have shown that it is linked to the collapse of the gel formed by red blood cells (RBCs) at physiological hematocrits (i.e. RBC volume fraction). Previous research has suggested that the observation of a slower initial dynamics is related to the formation of fractures in the gel. Moreover, RBC gels present specific properties due to the anisotropic shape and flexibility of the RBCs. Namely, the onset of the collapse is reached earlier and the settling velocity of the gel increases with increasing attraction between the RBCs, while the gel of spherical particles shows the opposite trend. Here, we report experimental observations of the gel structure during the onset of the collapse. We suggest an equation modeling this initial process as fracturing of the gel. We demonstrate that this equation provides a model for the motion of the interface between blood plasma and the RBC gel, along the whole time span. We also observe that the increase in the attraction between the RBCs modifies the density of fractures in the gel, which explains why the gel displays an earlier onset when the aggregation energy between the RBCs increases. Our work uncovers the detailed physical mechanism underlying the ESR and provides insights into the fracture dynamics of an RBC gel. These results can improve the accuracy of clinical measurements.

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Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

Cited by 2 publications

References 40 publications

Molecular Profiling of Inflammatory Arthritis

Molecular Profiling of Inflammatory Arthritis

Early stage of erythrocyte sedimentation rate test: Fracture of a high-volume-fraction gel

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