Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics
Guansheng Li,
He Li,
Papa Alioune Ndou
et al.
Abstract:The spleen constantly clears altered red blood cells (RBCs) from the circulation, tuning the balance between RBC formation (erythropoiesis) and removal. The retention and elimination of RBCs occur predominantly in the open circulation of the spleen, where RBCs must cross submicron-wide inter-endothelial slits (IES). Several experimental and computational studies have illustrated the role of IES in filtrating the biomechanically and morphologically altered RBCs based on a rigid wall assumption. However, these s… Show more
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