Red Blood Cell Metabolism in Experimental Animals

Suzuki, Takashige; Agar, Nicholas; Suzuki, Masatoshi

doi:10.1538/expanim1978.34.4_353

Cited by 10 publications

(2 citation statements)

References 77 publications

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“…These intracellular defenses include reduced glutathione (GSH), catalase, peroxiredoxins, and glutathione peroxidase. 12 , 13 Oxidative stress plays a major role in many anemia-inducing conditions, such as malaria and sickle cell disease (SCD). 14 , 15 In malaria, RBCs from patients have reduced levels of intracellular catalase, 16 indicating that these cells are deficient in their ability of fully combating oxidative stress and rendering avenues for antioxidant therapy as a viable treatment to lessen disease severity.…”

Section: Introductionmentioning

confidence: 99%

Amino acid supplementation confers protection to red blood cells before Plasmodium falciparum bystander stress

Binns,

Alipour,

Sherlock

et al. 2024

Blood Advances

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Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells (RBCs). Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in uninfected, catalase-depleted RBCs. As cell permeable precursors to glutathione, we show a benefit of pre-exposure to exogenous glutamine, cysteine, and glycine (QCG) amino acids for RBCs and that this pre-treatment intrinsically prepares RBCs to mitigate oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Amino acid supplementation confers protection to red blood cells before Plasmodium falciparum bystander stress

Binns,

Alipour,

Sherlock

et al. 2024

Blood Advances

View full text Add to dashboard Cite

show abstract

“…While mature RBCs have limited metabolic activity due to a lack of membrane-bound organelles, these cells have multiple active antioxidant components to counter oxidative stress in their environment. These defenses include reduced glutathione (GSH), catalase, peroxiredoxins, and glutathione peroxidase 11,12 . Oxidative stress plays a major role in many anemia-inducing conditions, such as malaria and sickle cell disease 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Amino acid supplementation confers protection to red blood cells prior to Plasmodium falciparum bystander stress

Binns,

Alipour,

Nahid

et al. 2023

Preprint

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Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells. Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in healthy uninfected RBCs. Additionally, we show the benefit of amino acid pre-exposure for RBCs and how this pre-treatment intrinsically prepares RBCs to mitigate oxidative stress.

show abstract