Red blood cell lifespan is reduced in severe aplastic anemia and improves with response to immunosuppressive treatment

Ye, Lei; Jing, Liping; Guo, Jie; Zhao, Xin; Peng, Guangxin; Li, Yuan; Li, Jianping; Fan, Huihui; Yang, Wenrui; Zhang, Fengkui; Zhang, Li

doi:10.1002/ajh.26344

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“…In healthy individuals, erythrocytes usually survive for an average of 120 days [1]. However, previous research has demonstrated that several conditions, including hereditary xerocytosis (HX), severe aplastic anemia (SAA), and sickle cell anemia (SCA), may result in a shortened lifespan of erythrocytes, leading to anemia [2][3][4][5][6][7]. Patients with renal insufficiency may experience varying degrees of anemia [8,9] that could be linked to reduced production of endogenous erythropoietin (EPO) and iron deficiency [10,11].…”

Section: Introductionmentioning

confidence: 99%