Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances

Zhang, Endong; Phan, Philana; Algarni, Hanan Ahmed; Zhao, Zongmin

doi:10.1007/s11095-022-03328-5

Cited by 16 publications

(9 citation statements)

References 251 publications

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“…The plasma membrane can be used to cloak NPs to prevent them from being cleared by the immune system 260,261 . The existence of “self‐markers” in the red blood cell membrane (RBCM) coating enables different NPs to decrease immunological attack 262 . Hu et al 263 developed an extrusion process by coating RBCM onto PLGA polymer NPs for the first time to form a biomimetic nanodelivery platform, who pioneered research in this field.…”

Section: Drug Delivery Strategies Using Nps For Cancer Therapymentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Drug Delivery Strategies Using Nps For Cancer Therapymentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…The unique features of functional RBCs could be leveraged for the use of RBCs as efficient drug delivery systems, which has already been implicated in different cardiovascular and metabolic diseases. [82][83][84] Their long presence in circulation, 85 their wide accessibility to multiple tissues, 83 the unique shape and lack of nucleus and organelles that gives them space to carry multiple cargos, 86 as well as the low immunogenicity that characterizes RBCs, 87 make them the perfect systems for drug delivery. Different therapeutic targets or molecules could be either loaded to the surface or inner cytoplasm of RBCs.…”

Section: Modulating Rbcs As a Potential Therapeutic Strategymentioning

confidence: 99%

Erythrocyte-Derived microRNAs: Emerging Players in Cardiovascular and Metabolic Disease

Kontidou

Collado

Pernow

et al. 2023

ATVB

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Recent studies have demonstrated a novel function of red blood cells (RBCs) beyond their classical role as gas transporters, that is, RBCs undergo functional alterations in cardiovascular and metabolic disease, and RBC dysfunction is associated with hypertension and the development of cardiovascular injury in type 2 diabetes, heart failure, preeclampsia, familial hypercholesterolemia/dyslipidemia, and COVID-19. The underlying mechanisms include decreased nitric oxide bioavailability, increased arginase activity, and reactive oxygen species formation. Of interest, RBCs contain diverse and abundant micro (mi)RNAs. microRNA expression pattern in RBCs reflects the expression in the whole blood, serum, and plasma. microRNA levels in RBCs have been found to be altered in various cardiovascular and metabolic diseases, which contributes to the development of cardiovascular complications. Evidence has shown that RBC-derived miRNAs interact with the cardiovascular system via extracellular vesicles and argonaute RISC catalytic component 2 as carriers. Alteration of RBC-to-vascular communication via miRNAs may serve as potential disease mechanism for vascular complications. The present review summarizes RBCs and their released miRNAs as potential mediators of cardiovascular injury. We further focus on the possible mechanisms by which RBC-derived miRNAs regulate cardiovascular function. A better understanding of the function of RBC-derived miRNAs will increase insights into the disease mechanism and potential targets for the treatment of cardiovascular complications.

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“…The red blood cell membrane (RBCM) possesses unique characteristics, including high biocompatibility, long circulating half-life, flexible and stable membrane, non-tumorigenicity, and large superficial surface area conducive to surface modification, which also proved to evade immunogenic clearance [ 85 , 86 ]. Lin et al used natural RBCM to construct a biomimetic multifunctional Ru-complex-functionalized SeNPs.…”

Section: Targeting Strategies For Senpsmentioning

confidence: 99%

Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy

2022

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As an essential micronutrient, selenium participates in numerous life processes and plays a key role in human health. In the past decade, selenium nanoparticles (SeNPs) have attracted great attention due to their excellent functionality for potential applications in pharmaceuticals. However, the utilization of SeNPs has been restricted by their instability and low targeting ability. Since the existing reviews mainly focused on the applications of SeNPs, this review highlights the synthesis of SeNPs and the strategies to improve their stability and targeting ability through surface functionalization. In addition, the utilization of functionalized SeNPs for the single and co-delivery of drugs or genes to achieve the combination of therapy are also presented, with the emphasis on the potential mechanism. The current challenges and prospects of functionalized SeNPs are also summarized. This review may provide valuable information for the design of novel functionalized SeNPs and promote their future application in cancer therapy.

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Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances

Cited by 16 publications

References 251 publications

Advances and applications of nanoparticles in cancer therapy

Advances and applications of nanoparticles in cancer therapy

Erythrocyte-Derived microRNAs: Emerging Players in Cardiovascular and Metabolic Disease

Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy

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