Red blood cell distribution width to platelet ratio predicts early neurological deterioration in acute ischemic stroke patients receiving intravenous thrombolysis

Jiang, Min; Shen, Jun; Bilal, Muhammad; Geng, Deqin

doi:10.1016/j.jstrokecerebrovasdis.2023.107146

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…The RPR, as a new inflammatory index, was closely related to the risk of mortality among AIS patients ( 63 , 64 ). Furthermore, an increase in RPR could also predict early neurological deterioration after intravenous thrombolysis in patients with AIS ( 65 ). It remains unclear whether any relationship exists between the MII-2 indicator and AIS patients, but a recent study elucidated that the MII-1 and MII-2 inflammatory markers were capable of predicting the occurrence of acute symptomatic seizures after IS ( 66 ).…”

Section: Discussionmentioning

confidence: 99%

Using a k-means clustering to identify novel phenotypes of acute ischemic stroke and development of its Clinlabomics models

Jiang,

Dang,

et al. 2024

Front. Neurol.

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ObjectiveAcute ischemic stroke (AIS) is a heterogeneous condition. To stratify the heterogeneity, identify novel phenotypes, and develop Clinlabomics models of phenotypes that can conduct more personalized treatments for AIS.MethodsIn a retrospective analysis, consecutive AIS and non-AIS inpatients were enrolled. An unsupervised k-means clustering algorithm was used to classify AIS patients into distinct novel phenotypes. Besides, the intergroup comparisons across the phenotypes were performed in clinical and laboratory data. Next, the least absolute shrinkage and selection operator (LASSO) algorithm was used to select essential variables. In addition, Clinlabomics predictive models of phenotypes were established by a support vector machines (SVM) classifier. We used the area under curve (AUC), accuracy, sensitivity, and specificity to evaluate the performance of the models.ResultsOf the three derived phenotypes in 909 AIS patients [median age 64 (IQR: 17) years, 69% male], in phenotype 1 (N = 401), patients were relatively young and obese and had significantly elevated levels of lipids. Phenotype 2 (N = 463) was associated with abnormal ion levels. Phenotype 3 (N = 45) was characterized by the highest level of inflammation, accompanied by mild multiple-organ dysfunction. The external validation cohort prospectively collected 507 AIS patients [median age 60 (IQR: 18) years, 70% male]. Phenotype characteristics were similar in the validation cohort. After LASSO analysis, Clinlabomics models of phenotype 1 and 2 were constructed by the SVM algorithm, yielding high AUC (0.977, 95% CI: 0.961–0.993 and 0.984, 95% CI: 0.971–0.997), accuracy (0.936, 95% CI: 0.922–0.956 and 0.952, 95% CI: 0.938–0.972), sensitivity (0.984, 95% CI: 0.968–0.998 and 0.958, 95% CI: 0.939–0.984), and specificity (0.892, 95% CI: 0.874–0.926 and 0.945, 95% CI: 0.923–0.969).ConclusionIn this study, three novel phenotypes that reflected the abnormal variables of AIS patients were identified, and the Clinlabomics models of phenotypes were established, which are conducive to individualized treatments.

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Section: Discussionmentioning

confidence: 99%

Using a k-means clustering to identify novel phenotypes of acute ischemic stroke and development of its Clinlabomics models

Jiang,

Dang,

et al. 2024

Front. Neurol.

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The changes in the oxygen transport capability of erythrocyte hemoglobin in patients with ischemic stroke

Trofimov,

Karasev,

Vlasova

2023

Regional blood circulation and microcirculation

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The statistics of acute cerebrovascular accident (ACC) has been disappointing for decades. It is especially interesting to study the oxygen transport properties of blood under stroke as a probable mechanism for progression of acute hypoxia of the nervous tissue. The aim of this research was to study changes in the structure and oxygen transport capacity of hemoglobin in patients with varying degrees of ischemic stroke severity using RAMAN spectroscopy. Materials and methods. There was a clinical cross-sectional observational study of patients (n=60) with stroke of ischemic origin. We did standard diagnostic procedures, RAMAN spectroscopy of blood smears (inVia™ Basis spectrometer (Renishaw, UK, laser wavelength 532 nm, power 1.5 mW), statistical analysis of the data. Results. The conformational structure of hemoporphyrin in erythrocytes of patients with stroke has significant differences from the results of relatively healthy donors, corresponding to the severity of the pathology. The content of oxyhemoglobin decreases by 7.1–16.1 % (p<0.05) relative to the control. The ability of hemoglobin to bind and release ligands increases by an average of 34.7–47.2 % (p<0.05) and 9.9–23.9 % (p<0.05), respectively. Ligand affinity increases by 30.1 %, 29.0 % and 47.3 % (p<0.05) under mild, moderate and severe forms of the disease. Conclusion. In the erythrocytes of patients with stroke of ischemic origin, the conformation of hemoglobin changes, its affinity for oxygen increases, and its oxygen transport function is modified. The revealed changes correlate with the severity of the stroke.

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Acil Cerrahi Müdahale Gerektiren Akut Bacak Embolisinde Kırmızı Kan Hücresi Dağılımı-Trombosit Oranının Tanısal Değerinin Değerlendirilmesi

ÇİÇEK,

ATALAY,

ÇELİK

et al. 2023

Genel Tıp Dergisi

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Background: The objective of this study was to evaluate the significance of the red blood cell distribution-to-platelet ratio (RPR) as a diagnostic indicator, derived from the initial hemogram measurements of patients who underwent emergent surgical treatment for acute leg embolism, by comparing it to a control group of healthy individuals. Methods: The study included 48 patients who underwent femoral embolectomy for acute lower limb ischemia, while an additional 49 individuals were enrolled as a control group. Demographic, clinical, and laboratory data were compared between the two groups. Using the receiver operating characteristic curve to determine the RPR cutoff value, the area under the curve, sensitivity, and specificity were calculated. Results: The age and gender distribution of both groups were comparable. The admission RPR values of patients who underwent surgery for acute embolism were statistically higher compared to healthy individuals (0.0677 (IQR: 0.0547-0.0803) vs. 0.0504 (IQR: 0.0441-0.0572), p

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Red blood cell distribution width to platelet ratio predicts early neurological deterioration in acute ischemic stroke patients receiving intravenous thrombolysis

Cited by 3 publications

References 67 publications

Using a k-means clustering to identify novel phenotypes of acute ischemic stroke and development of its Clinlabomics models

Using a k-means clustering to identify novel phenotypes of acute ischemic stroke and development of its Clinlabomics models

The changes in the oxygen transport capability of erythrocyte hemoglobin in patients with ischemic stroke

Acil Cerrahi Müdahale Gerektiren Akut Bacak Embolisinde Kırmızı Kan Hücresi Dağılımı-Trombosit Oranının Tanısal Değerinin Değerlendirilmesi

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