Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis

Zinellu, Angelo; Mangoni, Arduino A.

doi:10.3390/jcm10020286

Cited by 21 publications

(21 citation statements)

References 50 publications

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“…(19) Table 4 shows significant increase in RDW-SD, RDW-CV and decrease in MCVin patients with severity of disease, which is similar to the study done by Wang et al (18). Also, Zinellu & Mangoni et al (20) found that the severely ill COVID-19 patients had significantly elevated RDW in comparison to the patients without severity which is also consistent with our study, that the elevated RDW is associated with disease severity.…”

Section: Red Blood Cell Morphology In Covid;supporting

confidence: 91%

A Study of Red Blood Cell Indices among Covid 19 Individuals in Tertiary Care Triage Centre

A.Anitha,

P.Sudhakar,

S.Ramapriya

2021

ijop

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Background: SARS-CoV-2 infection is characterized by the development and progression of inflammatory responses. The exploration of prognostic predictors for patients with COVID-19 is vital for prompt clinical intervention. Our study aims to explore the predictive value of hematological parameters in categorization of patients with COVID-19.We aimed to investigate associations between hematological parameters and disease severity in patients with SARS-CoV-2infection.The red blood cell distribution width (RDW), an indicator of anisocytosis has emerged as a potential tool for risk stratification of critically ill patients. Materials and Methods: Retrospective study after getting approval from Institutional ethics committee was performed with data obtained from triage OPD in Chengalpattu Medical College & Hospital. The demographic, clinical, laboratory profile of COVID 19 positive patients who attended Triage OPD for a period of one month were collected. 3000 RT-PCR confirmed COVID positive patients of age group 20 to 70 years of both genders were included in the study. COVID 19 positive paediatric cases, antenatal and postnatal mothers, postoperative cases and sick cases admitted in COVID ICU were excluded from the study. Symptoms, associated co-morbidities and severity of COVID 19 were tabulated. Complete Blood Count measured by Automated Sysmex Analyser at the time of reporting to triage was noted. Red blood cell indices were analysed using SPSS 21.0 version. Results: There was statistically significant increase in RDW and decrease in MCV among patients with co-morbidity and severe illness compared to those with mild disease. There is no statistically significant difference in Red blood cell indices between patients with and without symptoms and patients without co-morbidities. Conclusion: RDW was found to be a screening tool to identify patients with severe COVID-19 and the results of this study suggest that RDW should be part of routine laboratory assessment and monitoring of COVID-19.

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Section: Red Blood Cell Morphology In Covid;supporting

confidence: 91%

A Study of Red Blood Cell Indices among Covid 19 Individuals in Tertiary Care Triage Centre

A.Anitha,

P.Sudhakar,

S.Ramapriya

2021

ijop

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“…A number of studies have reinforced this evidence, like showed in a meta-analysis carried out in Australia. The RDW values were significantly higher in patients with COVID-19 considered severe (severe clinical manifestations and/or intensive care support or even death), when compared with the patients that showed mild symptoms (Zinellu & Mangoni, 2021).…”

Section: Rdw and Covid-19mentioning

confidence: 82%

Red Blood Cell Distribution Width (RDW) as a prognostic marker for COVID-19: A literature review

Cunha

Carneiro

Tanaka

et al. 2021

RSD

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The Red Cell Distribution Width (RDW) is a component of blood count which gives the variation of erythrocytes, used in laboratory hematology. The analysis of this parameter is in evidence, as the increased levels of RDW seem to be a mortality predictor. The infections of the respiratory tract are in these conditions and the increase of RDW has already been related to severe acute respiratory syndrome (SARS). In December of 2019, the first cases of severe acute pneumonia caused by the SARS-CoV-2 virus emerged in China. The Corona Virus Disease-19 (COVID-19) has as most common clinical manifestations changes in the respiratory tract that range from mild to severe symptoms, requiring respiratory support in severe cases. Current evidence point to the increase of RDW value which is related to severity of the disease and mortality rates due to COVID-19. The large number of severe cases of COVID-19 shows the urgent of the identification of cheap diagnostic parameters and easy detection, which could be used for determining the prognosis of these patients. The RDW has been shown to be a potential biomarker due to the easy obtaining, low cost, and therefore, it can be an important guide to early and effective interventions.

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“…Mortality risk in Covid-19 seems to be associated with higher erythrocyte distribution width (RDW), a measure of heterogeneity of erythrocyte volume (Figure 2). In a meta-analysis of Covid-19 patients, higher RDW was associated with more severe disease [38]. The precise reason for this is unknown, but may involve reduced erythropoiesis or impaired erythrocyte clearance.…”

Section: The Erythrocyte and Virusmentioning

confidence: 99%

Erythrocytes as Biomarkers of Virus and Bacteria in View of Metal Ion Homeostasis

Johansson¹,

Falk²

2021

Erythrocyte - A Peripheral Biomarker for Infection and Inflammation

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The erythrocyte contributes to the immune system in several ways. It sequesters interferons, interleukins or chemokines and by binding nucleic acid. It binds virus and bacteria and may deliver bacteria to macrophages for phagocytosis. It may also kill bacteria directly with oxygen. For proper function of the erythrocyte, homeostasis of reactive oxygen species, selenium, metal ions and trace elements is important. Erythrocytes display morphological and metabolic changes in diseases like sepsis, and in several genetic diseases. Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), giving rise to the coronavirus disease 2019 (Covid-19), show many erythrocyte changes as compared to healthy controls. The erythrocyte responds to hemolysins by purinergic signaling leading to hemolysis or phosphatidylserine exposure on the plasma membrane. Phosphatidylserine marks erythrocytes for clearance by spleen macrophages. Regulated erythrocyte cell death, also called eryptosis, can be induced by oxidative stress, pathogen infection, and certain diseases like sepsis. Erythrocytes may, in the future, contribute more to diagnosis based on research and diagnostic technological development.

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Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis

Cited by 21 publications

References 50 publications

A Study of Red Blood Cell Indices among Covid 19 Individuals in Tertiary Care Triage Centre

A Study of Red Blood Cell Indices among Covid 19 Individuals in Tertiary Care Triage Centre

Red Blood Cell Distribution Width (RDW) as a prognostic marker for COVID-19: A literature review

Erythrocytes as Biomarkers of Virus and Bacteria in View of Metal Ion Homeostasis

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