Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy

Abstract

Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto the nanoerythrosomes by fusing tumor cell membrane–associated antigens with nanoerythrosomes. This tumor antigen–loaded nanoerythrosomes (nano-Ag@erythrosome) elicited antigen responses in vivo and, in combination with the anti–programmed death ligand 1 (PD-L1) blockade, inhibited the tumor growth in B16F10 and 4T1 tumor models. We also generated a tumor model showing that “personalized nano-Ag@erythrosomes” could be achieved by fusing RBCs and surgically removed tumors, which effectively reduced tumor recurrence and metastasis after surgery.

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

“…[74] Moreover, antigens preserved on the cancer cell membrane can serve as additional antigens that enhance APC presentation once delivered into the body. [42] Therefore, many efforts have been put in utilizing cancer cell membrane coated nanoparticles for targeted immunotherapy. Reproduced with permission.…”

“…Reproduced with permission. [42] Copyright 2019, The American Association for the Advancement of Science. Figure 10.…”

Engineering of chiral nanomaterials for biomimetic catalysis

“…Surface modification of the engineered nanocatalysts is considered to be an efficient technique for manipulating the biocatalytic activity. [66][67][68][69][70][71] For example, Xia's group used cyclodextrin (CD) molecules as a stabilizer and reducing agent to construct a multifunctional gold nanoplatform. 72 (Fig.…”

In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of Cancer Recurrence after Surgery

“…Engineered delivery scaffold could enable controlled release of immunetherapeutics with lower systemic toxic and side effect . For instance, fibrin hydrogel is a type of biomaterial formed by thrombin‐triggered polymerization of fibrinogen.…”