Red Blood Cell and Platelet Phenotype Prediction from Whole Genome Sequencing in 621 Sickle Cell Disease Patients: Correlation with Alloimmunization History, Serology and Other Genotyping Methods
Abstract:Introduction: Red blood cell (RBC) transfusions are central in the management of sickle cell disease (SCD), an inherited hemoglobinopathy characterized by hemolysis, acute pain, and multi-systemic complications. Extended matching of patient and donor RBC antigens is an established strategy to minimize alloimmunization, which can make provision of compatible blood difficult and can result in severe, even lethal hemolytic transfusion reactions. While RBC genotype matching has proven valuable in SCD transfusion p… Show more
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