Red Blood Cell Aggregation Measurement with 40- MHz Ultrasound Has a Possibility for Noninvasive Evaluation of Blood Glucose Level in Patients with Diabetes

Arakawa, Mototaka; Sakaki, Hiroki; Nagasawa, Kanta; Fukase, Akiyo; Mori, Shiro; Yashiro, Satoshi; Ishigaki, Yasushi; Kanai, Hiroshi

doi:10.1109/ultsym.2018.8580086

Cited by 4 publications

(2 citation statements)

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“…We have studied a noninvasive and quantitative method for measuring blood properties. [28][29][30][31][32][33][34][35][36][37] Saito et al assumed that RBCs aggregate as a single-sphere scatterer and estimated the size from the scattering characteristics extracted by normalizing the power spectrum measured from the vessel lumen with that from the rear wall using a focused ultrasound transducer. [28][29][30][31][32] We also examined the relationship between RBC aggregation using ultrasound and blood glucose level.…”

Section: Introductionmentioning

confidence: 99%

“…Sakaki et al compared the blood glucose levels with the parameters determined from changes in the scattering power spectra of the echoes from the vascular lumen before and after avascularization. 33,34) Fukase et al studied the relationship between the blood glucose levels and the brightness values of the B-mode image. 35) However, there are still problems, such as the low correlation between these parameters and the blood glucose levels and the lack of reproducibility of the results because of the variation in the data among the measurements.…”

Section: Introductionmentioning

confidence: 99%

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Estimation of aggregate size of red blood cell by introducing reference power spectrum measured for hemispherical ultrafine wire

Higashiyama

Mori

Arakawa

et al. 2022

Jpn. J. Appl. Phys.

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Noninvasive measurement of the degree of red blood cell (RBC) aggregation is useful for evaluating blood properties. In the present paper, we proposed a method to estimate the size of RBC aggregates without using the power spectrum of the posterior wall by introducing a reference scattering spectrum. The reference power spectra were calculated using the power spectrum measured for an ultrafine wire with a hemispherical tip. They were applied to the size estimation of microparticles simulating RBC aggregates. The estimated sizes were close to the true values, which shows that the calculated reference power spectra were suitable for accurate size estimation. The proposed method was also applied to in vivo measurements, and the estimated sizes between at rest and in RBCs aggregated by avascularization were successfully differentiated. This demonstrates that the proposed method will be useful for estimating the size of RBC aggregates.

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