Red baby syndrome a new disease due to parvovirus B-19 observed in Kerala

Abstract

Red Baby Syndrome is a new disease seen in infants and young children. Dramatic onset of clinical symptoms with high intensity, short duration and lack of similarity with other cutaneous lesions makes it distinct. Of 50 such patients studied over a period of 5 years, half were below one year of age. Abrupt onset of high fever and generalized erythema involving the entire skin, which is swollen and tender is characteristic. These children were highly irritable and had paradoxical cry when cuddled. Rapid resolution of symptoms occurred in 7-10 days with extensive desquamation. Routine investigations were normal, C-reactive protein was raised only in 10 patients. Human Parvo virus B-19 IgM antibodies were positive in 15 out of 24 patients. Real time polymerase chain reaction was positive for human parvovirus B 19 DNA in one. Histopathological changes in the skin biopsy showed post infectious vascular injury pattern.

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

“…The virus can persist post partum and has been documented to cause pure red cell aplasia (PRCA; [6]). Autoimmune processes [7,8] and the red-baby syndrome [9] are also seen in association with primary PV B19-infection.…”

Babies in dermatology

“…Red baby syndrome: it occurs in infants and young children due to parvovirus B19 infection. 15 There is an abrupt onset of high grade fever, generalized erythema with swelling and tenderness of skin. The child is highly irritable.…”

Emerging Viral Infections in India

“…Human bocavirus, a new human parvovirus identified in children with respiratory tract disease in 2005, has been reported from India as well [112]. Red Baby Syndrome, a new disease characterised by abrupt onset of high fever and generalized erythema involving the entire skin, seen in infants and young children associated with human parvovirus B-19 infection was recently reported from India [113].…”