Recyclable Keggin Heteropolyacids as an Environmentally Benign Catalyst for the Synthesis of New 2-Benzoylamino-N-phenyl-benzamide Derivatives under Microwave Irradiations at Solvent-Free Conditions and the Evaluation of Biological Activity

Abstract

2-Benzoylamino-N-phenyl-benzamide derivatives (5a–h) were prepared from 2-phenyl-3,1-(4H)-benzoxazin-4-one 3 and substituted anilines 4a–h in the presence of a Keggin-type heteropolyacids series (H3PW12O40·13H2O; H4SiW12O40·13H2O; H4SiMo12O40·13H2O; and H3PMo12O40·13H2O) as catalysts without solvent and under microwave irradiation. We found that the use of H3PW12O40·13H2O acid coupled to microwave irradiation allowed obtaining a high-yielding reaction with a short time. The compound structures were established by 1H-NMR and 13C-NMR. The antibacterial and antifungal activities of the synthesized compounds exhibited an inhibition of the growth of bacteria and fungi.

Synthesis and Characterisation of Monolacunary Keggin Monovanado-deca-tungstophosphate and Its Complexes with Transition Metal Cations

“…Their potential has not been completely explored [ 44 ]. For example, the recently, catalytic properties of different [PW 12-x V x ] n- anions proved to be interesting, especially for the oxidation of organic compounds [ 45 , 46 , 47 ]. Additionally, Keggin compounds with different compositions are recommended to be used in rechargeable batteries [ 46 ] or to fabricate mesoporous materials [ 48 , 49 ].…”

A new series of Schiff base derivatives bearing 1,2,3‐triazole: Design, synthesis, molecular docking, and α‐glucosidase inhibition

“…After that, the reaction mixture was poured into crushed ice and filtered off. Then, the precipitated product was purified by recrystallization in ethanol to obtain pure 2‐phenyl‐4 H ‐benzo[ d ][1,3]‐oxazin‐4‐ones 3 …”

“…After that, the reaction mixture was poured into crushed ice and filtered off. Then, the precipitated product was purified by recrystallization in ethanol to obtain pure 2-phenyl-4H-benzo[d][1,3]oxazin-4-ones 3 [28]. General procedure for the synthesis of 2mixture of 2-phenyl-4H-benzo[d][1,3]oxazin-4-ones 3 (1 mmol) and hydrazine 4 (1 mmol) in ethanol (15 ml) was stirred at room temperature for 12 hr.…”

Preparation of Polyoxometalate-Based Composite by Solidification of Highly Active Cobalt-Containing Polytungstate on Polymeric Ionic Liquid for the Efficient Isolation of Proteinase K

“…Due to their strong acidity and redox properties, POMs have been widely used in the fields of electrochemistry, green chemistry, medicine, and so on [1]. Among them, POMs with the Keggin structure are the most widely studied as they exhibit the characteristics of both complexes and metallic oxides [2]. The Keggin structure consists of a central tetrahedron XO 4 that is surrounded by a metal oxygen octahedron MO 6 , consisting of 12 shared angles.…”