Recyclable CuO nanoparticles-catalyzed synthesis of novel-2,5-disubstituted 1,3,4-oxadiazoles as antiproliferative, antibacterial, and antifungal agents

Murty, M. S. R.; Penthala, Raju; Buddana, Sudheer Kumar; Prakasham, R. S.; Das, Pompi; Polepalli, Sowjanya; Jain, Nishant; Sreedhar, B.

doi:10.1007/s00044-014-1025-x

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…Murty et al [ 54 ] synthesized 1,3,4-oxadiazoles–pyridines 117a – 117c through an oxidative C–O coupling by direct C–H bond activation of N-aroyl-N-arylidinehydrazines 116a – 116c using a catalytic quantity of CuO nanoparticles ( Scheme 25 ). Compound 117a showed broad-spectrum antibacterial activity for all tested strains, E. coli , B. subtilis, M. luteus, K .…”

Section: Synthesis Of Antimicrobial Pyridine Compounds Containing a F...mentioning

confidence: 99%

“…Compounds 148a and 148b showed excellent antibacterial activity against S. epidermidis , with MIC values of 16 μg mL −1 and 32 μg mL −1 , respectively, taking Streptomycin sulfate as standard (MIC > 16 μg mL −1 ). Solankee and co-workers reported [ 63 ] that compound 149 ( Figure 14 ) exhibited promising antibacterial activity against Micrococcus flavus with a zone of inhibition value (iv) of 7 mm, which was slightly less active than the standard Ampicillin (iv = 8mm) [ 54 ]. Rajavelu and Rajkumar reported [ 64 , 65 ] synthesis of triazino- oxacalixarenes 150 and 151 and their good antibacterial activity against E. coli (MIC = 50 μgmL −1 ).…”

Section: Synthesis Of Antimicrobial Pyridine Compounds Containing a S...mentioning

confidence: 99%

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Pyridine Compounds with Antimicrobial and Antiviral Activities

Marinescu

Popa

2022

IJMS

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In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2 virus, finding new antiviral and antimicrobial compounds is a priority in current research. Pyridine is a privileged nucleus among heterocycles; its compounds have been noted for their therapeutic properties, such as antimicrobial, antiviral, antitumor, analgesic, anticonvulsant, anti-inflammatory, antioxidant, anti-Alzheimer’s, anti-ulcer or antidiabetic. It is known that a pyridine compound, which also contains a heterocycle, has improved therapeutic properties. The singular presence of the pyridine nucleus, or its one together with one or more heterocycles, as well as a simple hydrocarbon linker, or grafted with organic groups, gives the key molecule a certain geometry, which determines an interaction with a specific protein, and defines the antimicrobial and antiviral selectivity for the target molecule. Moreover, an important role of pyridine in medicinal chemistry is to improve water solubility due to its poor basicity. In this article, we aim to review the methods of synthesis of pyridine compounds, their antimicrobial and antiviral activities, the correlation of pharmaceutical properties with various groups present in molecules as well as the binding mode from Molecular Docking Studies.

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Section: Synthesis Of Antimicrobial Pyridine Compounds Containing a F...mentioning

confidence: 99%

Section: Synthesis Of Antimicrobial Pyridine Compounds Containing a S...mentioning

confidence: 99%

Pyridine Compounds with Antimicrobial and Antiviral Activities

Marinescu

Popa

2022

IJMS

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“…In relation to copper nanocatalysts, CuONPs have found remarkable applications in the synthesis of heterocycles. Substituted oxadiazoles showing antiproliferative, antibacterial, and antifungal properties, have been prepared by aerobic imine C(sp 2 )–H functionalization from N -aroyl- N -arylidenhydrazines . A large scope has been carried out (20 new compounds) affording high isolated yields (75–90%) under moderate heating conditions (80 °C) (Figure ).…”

Section: C(sp2)–hmentioning

confidence: 99%

“…Substituted oxadiazoles showing antiproliferative, antibacterial, and antifungal properties, have been prepared by aerobic imine C(sp 2 )−H functionalization from N-aroyl-N-arylidenhydrazines. 72 A large scope has been carried out (20 new compounds) affording high isolated yields (75−90%) under moderate heating conditions (80 °C) (Figure 22). After three catalytic runs (showing a slight yield decrease), CuONPs exhibited the same morphology (scanning electron microscopy (SEM) and TEM analyses) and structure (X-ray diffraction (XRD) data) than those observed before use.…”

Section: Acs Catalysismentioning

confidence: 99%

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Metal and Metal Oxide Nanoparticles: A Lever for C–H Functionalization

2016

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The past decade has seen the development of a new reactivity concept, exploiting the ubiquity of C−H bonds. The direct activation of this bond type brings forth a straightforward way for the derivatization of organic molecules. Consequently, the design of metal catalyzed C−H bond functionalization reactions has become a flourishing area in organic synthesis. Thus, this review focuses on molecular transformation of "unactivated" C(sp 3 )−H and C(sp 2 )−H bonds present in feedstock and readily available hydrocarbons into valuable chemicals by nanoparticle-leveraged C−H activation, resulting in more sustainable approaches for industrial applications. The distinctive reactivity properties of these nanoentities lead to remarkable reactivity specificities depending on the type of surface sites and the structure dynamics, directly impacting the process selectivity.

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