Recurring Staphylococcal Scalded Skin Syndrome‐like Bullous Mastocytosis: The Utility of Cytodiagnosis and the Rapid Regression with Steroids

Has, Cristina; Miséry, Laurent; L, David; Cambazard, F.

doi:10.1046/j.1525-1470.2002.00077.x

Cited by 23 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These patients often show widespread erythema. It mimics other diseases such as staphylococcal scalded skin syndrome and bullous erythema multiforme [14,18,19,20]. On the other hand, the disease shows yellow-orange infiltrations (xanthogranuloma-like abnormalities) and minimal small blistering.…”

Section: Discussionmentioning

confidence: 93%

Clinical Aspects of Diffuse Cutaneous Mastocytosis in Children: Two Variants

Heide¹,

Zuidema²,

Beishuizen

et al. 2009

Dermatology

View full text Add to dashboard Cite

Objective: This paper describes two different clinical presentations of diffuse cutaneous mastocytosis (DCM), based on the largest series published to date. As far as we are aware, these two variants of clinical presentations have not yet been reported. Design: We undertook a case controlled analysis of 8 children with DCM. Results of laboratory testing including mast cell mediator levels, and clinical symptoms on presentation and during follow-up were analyzed. Results: The levels of relevant mast cell mediators were initially high in all cases but declined sharply later on. There was a reduction of 20% in 2 of the 7 cases, whereas there was a reduction of 80% in the remaining 5. No reduction occurred in 1 case. Clinical improvement followed the same pattern. Conclusions: DCM is a rare variant of cutaneous childhood onset mastocytosis. Various forms show the same or overlapping features at various times. It appears to follow a course similar to that in other types of childhood onset mastocytosis, taking into account the decreased symptoms and the levels of mast cell mediators during follow-up. Obtaining a bone marrow biopsy should be considered only in those cases where there is no improvement or even worsening of signs or symptoms and persistent elevated levels of mast cell mediators.

show abstract

Section: Discussionmentioning

confidence: 93%

Clinical Aspects of Diffuse Cutaneous Mastocytosis in Children: Two Variants

Heide¹,

Zuidema²,

Beishuizen

et al. 2009

Dermatology

View full text Add to dashboard Cite

show abstract

“…Systemic and topical corticosteroids have demonstrated good therapeutic results in some cases of bullous mastocytosis, as reported in the literature [11, 12]. …”

Section: Discussionmentioning

confidence: 90%

Cutaneous Mastocytosis with Persistent Blistering: Successful Treatment with Methylprednisolone and 3-Year Follow-Up Management

Yankova

Abadjieva

Belovezhdov

2015

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

BackgroundMastocytosis is a rare disorder with diverse clinical manifestations. In cutaneous mastocytosis the mast cell infiltration is limited to the skin, but is often associated with systemic symptoms due to the release of mast cell mediators.Case ReportWe report a 6-month-old male infant who had skin lesions of various morphologies (macules, papules, plaques, and nodules) and sizes, persistent blistering and frequent flushing episodes for half a year. Vital signs and physical examinations were unremarkable. No abnormalities in the laboratory tests were found except for a serum tryptase level (STL) of 11.8 ng/ml. The histological and immunohistochemical examinations confirmed the diagnosis of cutaneous mastocytosis. The patient was first treated with methylprednisolone, oral levocetirizine, and topical fusidic acid/betamethasone cream. Subsequently the treatment was tapered and stopped within 9 weeks. The child’s symptoms improved and were successfully controlled with intermittent courses of ketotifen and topical hydrocortisone over 3 years.ConclusionChildhood cutaneous mastocytosis usually has a favorable prognosis, but in some cases the disease can progress with skin manifestations necessitating a more active systemic and topical treatment.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-015-0073-6) contains supplementary material, which is available to authorized users.

show abstract

“…The blisters present in a variety of sizes and initially contain clear fluid that may become hemorrhagic with time. Bullous lesions may occur in linear or grouped fashion and often develop on the trunk, scalp, and extremities 14 . These lesions typically resolve by 3 to 5 years of age without scarring.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, DCM is seen initially almost exclusively in infants, although it may persist into adult life and has been associated with indolent systemic mastocytosis 15 . DCM associated with generalized bullae has a relatively poor prognosis, as this presentation has a higher rate of transformation to SM, which could cause hepatomegaly, splenomegaly, lymphadenopathy, large bone osteolysis, and anemia or pancytopenia due to bone marrow involvement 6,[12][13][14]16 . DiBacco and DeLeo 17 reported on eight infants that manifested bullae as their initial symptom of DCM.…”

Section: Discussionmentioning

confidence: 99%