Recurring, Painful Oral Ulcers

Correll, Ralph W.; Wescott, William B.; Jensen, Jerald L.

doi:10.14219/jada.archive.1981.0334

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…The presence of oral symptoms or lesions such as aphthoid ulcerations should alert the clinician to the possibility of IBD even in the absence of GI manifestations (Correll, Wescott and Jensen, 1981; Frankel and Mostofi, 1985; Plauth et al , 1991; Halme et al , 1993).…”

Section: Discussionmentioning

confidence: 99%

Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease

et al. 2003

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The present study demonstrates increased frequency of oral signs and symptoms in patients with IBD. Patients with active CD had more oral signs compared with non-active CD patients. Manifestations such as nausea, vomiting, regurgitation and dry mouth may have detrimental effects on teeth and soft tissues of the oral cavity. Communication between gastroenterologists and dentists is imperative for success of the overall treatment of their patients.

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Section: Discussionmentioning

confidence: 99%

Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease

et al. 2003

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“…Any patient with recurring or insisting oral ulcers should be evaluated medically for the possible presence of later development of a more serious systemic disease …”

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

“…Aphthous‐like lesions may be seen in 4–5% of patients with IBD . They can be located anywhere in the oral cavity.…”

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

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Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Κατσάνος

Torres

Roda

et al. 2015

Aliment Pharmacol Ther

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Summary Background Patients with inflammatory bowel diseases (IBD) may present with lesions in their oral cavity. Lesions may be associated with the disease itself representing an extraintestinal manifestation, with nutritional deficiencies or with complications from therapy. Aim To review and describe the spectrum of oral nonmalignant manifestations in patients with inflammatory bowel diseases [ulcerative colitis (UC), Crohn's disease (CD)] and to critically review all relevant data. Methods A literature search using the terms and variants of all nonmalignant oral manifestations of inflammatory bowel diseases (UC, CD) was performed in November 2014 within Pubmed, Embase and Scopus and restricted to human studies. Results Oral lesions in IBD can be divided into three categories: (i) lesions highly specific for IBD, (ii) lesions highly suspicious of IBD and (iii) nonspecific lesions. Oral lesions are more common in CD compared to UC, and more prevalent in children. In adult CD patients, the prevalence rate of oral lesions is higher in CD patients with proximal gastrointestinal tract and/or perianal involvement, and estimated to range between 20% and 50%. Oral lesions can also occur in UC, with aphthous ulcers being the most frequent type. Oral manifestations in paediatric UC may be present in up to one‐third of patients and are usually nonspecific. Conclusions Oral manifestations in IBD can be a diagnostic challenge. Treatment generally involves managing the underlying intestinal disease. In cases presenting with local disabling symptoms and impaired quality of life, local and systemic medical therapy must be considered and/or oral surgery may be required.

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“…Recurrent ulcerations of oral mucosae are often associated with ulcerations in other portions of the gastrointestinal tract, for example in Lesniewski-Crohn's disease, ulcerative colitis, neutropenia, allergies, or Behçet's syndrome. It has been proposed that any patient with recurring oral ulcers should be evaluated clinically for the possible presence of later development of a more serious systemic diseases (Correll et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone

et al. 2007

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Hormonal fluctuations are known to predispose ulceration of the upper gastrointestinal tract, but to date no comparative study of their effects on the healing of pre-existing ulcers in the oral cavity and stomach has been made. We studied the effects of depletion of testosterone and of EGF on the healing of acetic acid-induced ulcers using rats having undergone bilateral orchidectomy and/or salivectomy respectively. We measured alterations in gastric acid secretion and blood flow at ulcer margins, as well as plasma levels of testosterone, gastrin and the proinflammatory cytokines IL-1 beta and TNF-alpha. Testosterone (0.01-10 mg/kg/day i. m.) dose-dependently delayed oral and gastric ulcer healing. When applied in an optimal dose of 1 mg/kg/day, this hormone significantly raised gastric acid secretion and plasma IL-1 beta and TNF-alpha levels. Attenuation of plasma testosterone levels via bilateral orchidectomy inhibited gastric acid secretion and accelerated the healing of oral and gastric ulcers, while increasing plasma gastrin levels and these effects were reversed by testosterone. Salivectomy raised plasma testosterone levels, and delayed oral and gastric ulcer healing. Treatment of salivectomised animals with testosterone further inhibited ulcer healing, and this effect was counteracted by EGF. We propose that testosterone delays ulcer healing via a fall in blood flow at the ulcer margin, a rise in plasma levels of IL-1 beta and TNF-alpha and, in the case of gastric ulcers, an increase in gastric acid secretion. EGF released from the salivary glands plays an important role in limitation of the deleterious effects of testosterone on ulcer healing.

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Recurring, Painful Oral Ulcers

Cited by 11 publications

References 7 publications

Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease

Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone

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