Recurring facial low-grade fibromyxoid sarcoma in an elderly patient: A case report

Abe, Yoshiro; Hashimoto, Ichiro; Nakanishi, Hideki

doi:10.2152/jmi.59.266

Cited by 16 publications

(17 citation statements)

References 7 publications

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“…Herein we have the opportunity to describe an atypical recurrent LGFMS, which concerns an 81-year-old male. This specific clinical case is rare, as based on the previous reports and the sparse literature; it was found in the neck (atypical location) of an older male (low age incidence) in close proximity with the left carotid sheath and as a result the neoplasm not only constricts, but also causes internal jugular vein thrombosis (IJVT), a rare and serious clinical entity with a potentially fatal outcome [8].…”

Section: Discussionmentioning

confidence: 96%

“…Tumor cells generally present none or negligible nuclear and cellular pleomorphism. In addition, the observed mitotic rate is significantly low; at most 1 mitotic figure per 10 high-power fields (HPF) is commonly noticed, though that number may be higher in metastases [7,8]. Besides these typical microscopic findings, other structures have been recorded in the literature, such as osseous metaplasia, pericollagenous rosettes, cyst formation, and atypical growth patterns, including storiform or fascicular-herringbone [9].…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Low-Grade Fibromyxoid Sarcoma of the Neck: Report of a Case and Review of the Literature

Mastoraki

Strigkos

Tatakis

et al. 2015

Indian J Surg Oncol

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Low-grade fibromyxoid sarcoma (LGFMS) represents a rare, indolent, benign neoplasm that proliferates at various anatomical locations. Histologically, the tumor consists of bland, deceptively benign-appearing spindle cells in a whirling pattern, as well as myxoid and collagenized stroma. The current treatment includes surgical excision. The aim of this investigation was to analyze a rare clinical case of recurrent LGFMS of the neck. Relevant literature is briefly reviewed. An 81-year-old male was admitted with an enlarging painless nontender mass in the neck. The patient referred a past medical history of LGFMS. Magnetic Resonance Imaging (MRI) depicted a large, well-defined mass in the lower neck and supraclavicular area, extending till the left upper area of the anterior thoracic wall. Based on the imaging characteristics and the medical history, a wide surgical excision of a 5.6×6.6×3.3 cm area, in close proximity to the cervical vertebrae was performed. On microsopic examination, the tumor contained alternating fibrous and mixoid components, with mixed hypo-and hyper-cellular areas, minimal necrosis and negligible cellular pleomorphism or nuclear atypia. As LGFMS is a soft tissue malignancy, any recurrences are usually local; therefore treatment of choice is radical, wide margin surgical excision. Nevertheless, the ideal goal of large safety margin of healthy tissue might be unattainable if it requires resection of vital anatomic structures. Because LGFMS has a very low mitotic rate, neither chemotherapy nor radiotherapy is expected to have significant effect on long-term prognosis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Recurrent Low-Grade Fibromyxoid Sarcoma of the Neck: Report of a Case and Review of the Literature

Mastoraki

Strigkos

Tatakis

et al. 2015

Indian J Surg Oncol

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“…Typically presenting as a deep‐seated (below fascia) soft tissue painless mass mostly affecting the extremities and trunk . LGFMS has been reported in variable anatomic locations including the head and neck, gastrointestinal tract, heart, kidney, and brain . Involvement of acral sites is not highly emphasized in the literature.…”

Section: Discussionmentioning

confidence: 99%

Low‐grade fibromyxoid sarcoma of acral sites: Case report and literature review

Saab‐Chalhoub

Al‐Rohil

2019

J Cutan Pathol

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Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue sarcoma that usually presents as a deep-seated tumor in young adults; however, they can occur on superficial sites, mostly documented in pediatric age groups.LGFMS presenting on acral sites is not highly emphasized in the general pathology or dermatopathology literature. The case presented is that of a 30-year-old man with a foot mass that was removed 15 years earlier and subsequently recurred as two masses, the first occurring between the third and fourth toes/metatarsal region and the second over the lateral tarsal region. An excisional biopsy showed a relatively circumscribed, bland spindle cell proliferation with hypocellular and hypercellular zones. The cells showed minimal pleomorphism and lacked mitotic activity. Immunohistochemical analysis showed immunoreactivity for MUC4 and break-apart fluorescence in situ hybridization was positive for FUS rearrangement, confirming the diagnosis of LGFMS. There are multiple spindle cell tumors that occur on acral sites which usually generates a list of differential diagnoses; however, LGFMS is not usually discussed in that anatomic location. Awareness of the occurrence of LGFMS on acral sites is important to avoid misdiagnosis of this deceptively benign-appearing tumor.

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“…Malignant soft-tissue tumors rarely occur in the head and neck, and surgeons are challenged in determining the optimal method for tumor excision, particularly in the case of tumors located in the face [ 1 ]. Moreover, an accurate diagnosis of soft-tissue tumors is often complicated even for well-trained pathologists because of the histologic characteristics of these tumors.…”

mentioning

confidence: 99%

“…Moreover, an accurate diagnosis of soft-tissue tumors is often complicated even for well-trained pathologists because of the histologic characteristics of these tumors. LGFMS is a rare type of sarcoma, and the determination of the disease course based on oncologic and histologic features remains controversial [ 1 ]. LGFMS is a rare tumor type first described by Evans in 1987 [ 1 ].…”

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confidence: 99%