Recurring episodes of acute pancreatitis following Clozapine, Olanzapine, and Quetiapine in a bipolar patient

Milano, Beatrice Annunziata; Saccaro, Luigi Francesco; Grande, Claudia Del

doi:10.1016/j.psycr.2022.100063

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…In this narrative review, we discuss the involvement of ED in three common and potentially debilitating diseases, defined henceforth as Emotion Dysregulation Disorders (EDD): bipolar disorder (BD) (3,4), attention deficit and hyperactivity disorder (ADHD) (5), and borderline personality disorder (BPD) (6,7). These diseases have a profound socioeconomic impact and high prevalence (0.8-2.4% for BD (8,9), 2.5-15% for ADHD (10), and 2.7-6% for BPD (11,12), see also (13)), and are often comorbid with one another (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Increasing evidence shows substantial benefits of early interventions in individuals at risk for EDD (27)(28)(29)(30)(31), but there is a compelling need for deeper pathophysiological insights.…”

Section: Emotion Regulation and (Neuro)inflammation In Emotion Dysreg...mentioning

confidence: 99%

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

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Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well as when and how these emotions are experienced or expressed. It is a focal overarching symptom in many severe and prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit and hyperactivity disorder (ADHD), and borderline personality disorder (BPD). In all these disorders, ED can manifest through symptoms of depression, anxiety, or affective lability. Considering the many similarities in symptoms between BD, ADHD, and BPD, a transdiagnostic approach is a promising lens of investigation. Mounting evidence supports the role of peripheral inflammatory markers and stress in the multifactorial aetiology and physiopathology of BD, ADHD, and BPD. Of note, neural circuits that regulate emotions appear particularly vulnerable to inflammatory insults and peripheral inflammation, which can impact the neuroimmune milieu of the central nervous system. Thus far, few studies have examined the link between ED and inflammation in BD, ADHD, and BPD. To our knowledge, no specific work has provided a critical comparison of the results from these disorders. To fill this gap in the literature, we review the known associations and mechanisms linking ED and inflammation in general, and clinically, in BD, ADHD, and BD. Our narrative review begins with an examination of the routes linking ED and inflammation, followed by a discussion of disorder-specific results accounting for methodological limitations and relevant confounding factors. Finally, we critically discuss both correspondences and discrepancies in the results and comment on potential vulnerability markers and promising therapeutic interventions.

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Section: Emotion Regulation and (Neuro)inflammation In Emotion Dysreg...mentioning

confidence: 99%

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Recurring episodes of acute pancreatitis following Clozapine, Olanzapine, and Quetiapine in a bipolar patient

Cited by 1 publication

References 22 publications

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

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