Recurrent Vestibulopathy: Comparison of Vestibular Test Results with Ménière’s Disease and Vestibular Migraine

Kaçan, Melis; Kirazlı, Gülce; Balayeva, Fidan; Çelebisoy, Neşe

doi:10.1159/000526814

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…A previous study reported that low cVEMP amplitudes on the affected side were the main feature in MD, differentiating it from VM. [52] Flook et al [53] found that a cytokine panel including interleukin 1, beta, Chemokine (C-C motif) ligand 3, Chemokine (C-C motif) ligand 22, and Chemokine (C-X-C motif) ligand 1, could be used as biological markers for the differential diagnosis of VM and MD, suggesting a high diagnostic value in patients with symptom overlap. Moreover, the team attempted to use prestin and otolin-1 as biomarkers to differentiate between MD and VM.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Wang

Zhang

et al. 2023

Medicine

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Background: Meniere's disease (MD) is a clinical condition characterized by endolymphatic hydrops. Persistent symptoms negatively affect patients mood, and the underlying etiology remains unclear. It is necessary to comprehensively understand the relevant publications, review the history and current status of research, and analyze hotspots and frontiers of research on MD.Methods: We retrieved literature on Meniere's disease from 2003 to 2022 from the Web of Science database and extracted the data. Data visualization and analysis was conducted using Cite Space, VOS viewer, an online web tool, and Microsoft Office Power Point 2019.Results: In total, 2847 publications were analyzed. The number of annual publications was relatively stable, with an accelerated upward trend over the past 5 years. The country with the most publications was USA (751, 26.38%), while the University of Munich contributed more publications than any other institution (117, 4.11%). The article titled "Diagnostic criteria for Meniere's disease" by Lopez-Escamez J et al in 2015 was the most cited and co-cited publication, and also had the top co-cited references with the strongest citation bursts. Naganawa S was the author with the most publications (85, 2.99%). The top 3 journals and co-cited journals were Otology Neurotology, Acta Oto Laryngologica, and Laryngoscope. Recently, the key theme words were "sensorineural hearing loss," "therapy," "intratympanic injection method," "vestibular-evoked myogenic potentials," "vestibular migraine," "magnetic resonance imaging," and "meniere's disease." Conclusions:The US has the largest number of publications and research institutions, many European countries have highquality journals, and Japan has the highest number of scholars. The international opinion on Meniere's disease is relatively uniform. The stepped-therapy for MD is scientific and clear. Intratympanic injection of steroids and intratympanic injection of gentamicin are commonly used, but steroids are considered safer. Saccular dysfunction may be more common in patients with MD than in those with utricular dysfunctions. It is worth paying attention to study the relationship between MD and vestibular migraine through headache. Progress in magnetic resonance imaging technology is still required for the imaging diagnosis of MD.

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Section: Discussionmentioning

confidence: 99%

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Wang

Zhang

et al. 2023

Medicine

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vHIT and fHIT in Patients With Migraine, Vestibular Migraine, and Persistent Postural‐Perceptual Dizziness

Kirazli,

Balayeva,

Kacan Yilmaz

et al. 2024

The Laryngoscope

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ObjectiveImpairment in the integration of different vestibular stimuli is the proposed mechanisms in vestibular migraine (VM). In this study, it was aimed to assess the vestibulo‐ocular reflex (VOR) and dynamic visual acuity (DVA) in patients with VM and to compare the results with migraine without vestibular symptoms (MwoV), and persistent postural‐perceptual dizziness (PPPD) to find out if there are discriminative differences and search for a correlation with the levels of anxiety.MethodsTwenty‐two patients with MwoV, 23 patients with VM, 22 patients with PPPD, and 23 healthy controls (HC) were studied. Video head impulse test (vHIT) and functional head impulse test (fHIT) without and with an optokinetic background (OB) were performed. Percentage of correctly identified optotypes (CA%) was considered for the fHIT test. Beck anxiety inventory (BAI) was used to assess anxiety.ResultsLateral canal vHIT gain of the patient groups were not different from the healthy controls (p > 0.05). fHIT and fHIT/OB CA% results of all patient groups were lower than the HC (p < 0.005), and VM patients had the lowest scores for both tests. BAI scores of the PPPD patients were the highest and a correlation between anxiety levels, and fHIT results could not be identified (p > 0.05).ConclusionProminent CA% drop by the use of an OB was the main finding in patients with VM. This discriminative feature was not correlated with anxiety scores. Difficulty in resolving the conflict between visual and vestibular inputs seem to be the underlying mechanism.Level of Evidence3 Laryngoscope, 2024

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Update on the pathophysiology, diagnosis and management of Ménière's disease

Lopez-Escamez,

Perez-Carpena

2024

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of the review The aim of this work is to summarize the main advances on the pathophysiology, diagnosis, and treatment of Meniere's disease (MD). Recent findings Different immune responses to biotic stimuli may trigger MD, with subgroups identified based on cytokine and genetic profile, suggesting potential benefits from immune therapy, including antiallergic medication. Genetic and epigenetic research, along with imaging studies, reveal the complexity of MD, involving inflammation, immunity, and metabolic processes. Advanced imaging techniques define specific temporal bone features and endolymphatic hydrops, while machine learning models enhance diagnostic accuracy through clinical and laboratory data analysis. Differentiating MD from vestibular migraine remains challenging due to overlapping symptoms, but combining vestibular tests, audiological assessments, and biomarkers like cytokines and chemokines shows promise. Pharmacological treatments such as betahistine or corticosteroids show varying effectiveness and require further research according to immune subgroups. Surgical options like endolymphatic sac decompression, semicircular canal occlusion and labyrinthectomy are restricted to intractable cases. Summary Research into MD aims to improve diagnosis and treatment through genetic, immunological, and advanced imaging studies. Current treatments include pharmacological, intratympanic, and surgical interventions, but current research supports a personalized approach based on clinical and molecular re-definition of patient subgroups.

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Recurrent Vestibulopathy: Comparison of Vestibular Test Results with Ménière’s Disease and Vestibular Migraine

Cited by 3 publications

References 52 publications

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

vHIT and fHIT in Patients With Migraine, Vestibular Migraine, and Persistent Postural‐Perceptual Dizziness

Update on the pathophysiology, diagnosis and management of Ménière's disease

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