Recurrent urinary tract infections: a critical review of the currently available treatment options

Negus, Mike; Phillips, Christian; Hindley, Richard G.

doi:10.1111/tog.12644

Cited by 11 publications

(13 citation statements)

References 43 publications

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“…Based on current international guidelines, nitrofurantoin, fosfomycin, trimethoprim/sulfamethoxazole and mecillinam are recommended first-line agents for the therapy of uncomplicated UTIs [ 14 , 15 , 16 ]. In case of complicated infections or patient characteristics for complicated UTIs, drug allergies or extensive resistance to the abovementioned drugs, third generation cephalosporins, carbapenems and aminoglycosides may also be considered [ 17 ]. Fluoroquinolones have previously been used as first-line agents in the therapy of UTIs.…”

Section: Introductionmentioning

confidence: 99%

Association between Biofilm-Production and Antibiotic Resistance in Uropathogenic Escherichia coli (UPEC): An In Vitro Study

2020

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Urinary tract infections (UTIs) are among the most common infections requiring medical attention worldwide. The production of biofilms is an important step in UTIs, not only from a mechanistic point of view, but this may also confer additional resistance, distinct from other aspects of multidrug resistance (MDR). A total of two hundred and fifty (n = 250) Escherichia coli isolates, originating from clean-catch urine samples, were included in this study. The isolates were classified into five groups: wild-type, ciprofloxacin-resistant, fosfomycin-resistant, trimethoprim-sulfamethoxazole-resistant and extended spectrum β-lactamase (ESBL)-producing strains. The bacterial specimens were cultured using eosine methylene blue agar and the colony morphology of isolates were recorded. Antimicrobial susceptibility testing was performed using the Kirby–Bauer disk diffusion method and E-tests. Biofilm-formation of the isolates was carried out with the crystal violet tube-adherence method. n = 76 isolates (30.4%) produced large colonies (>3 mm), mucoid variant colonies were produced in n = 135 cases (54.0%), and n = 119 (47.6%) were positive for biofilm formation. The agreement (i.e., predictive value) of mucoid variant colonies in regard to biofilm production in the tube-adherence assay was 0.881 overall. Significant variation was seen in the case of the group of ESBL-producers in the ratio of biofilm-producing isolates. The relationship between biofilm-production and other resistance determinants has been extensively studied. However, no definite conclusion can be reached from the currently available data.

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Section: Introductionmentioning

confidence: 99%

Association between Biofilm-Production and Antibiotic Resistance in Uropathogenic Escherichia coli (UPEC): An In Vitro Study

2020

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“…These may include issues during sample procurement and time elapsed before sample has been processed (i.e. the pre-analytical phase), however, troubleshooting must also encompass steps in the analytical phase [27]. The chemical composition of urine clearly affects the viability and species-composition of bacteria, for example, if the pH of the urine shifts in either directions, it may inhibit or potentiate the replication of several microorganisms [26,27].…”

Section: Discussionmentioning

confidence: 99%

“…From the standpoint of public health, UTIs represent an important factor or morbidity and mortality, affecting both patients in primary care and tertiary care settings [3]. In fact, according to some estimates, around 50-60% of women in the age range of 20-40 years experience a UTI at least once during their lifetime, while nosocomial UTIs may represent 25-50% of hospital-acquired infections overall [4]. The diagnosis and management of UTIs, and the corresponding lost working days associated with these infections also have a significant economic consequence, estimated to be around 3-5 billion US dollars annually [5,6].…”

Section: Introductionmentioning

confidence: 99%

Non-antibiotic compounds affecting the growth of urinary pathogens during urine culture: a preliminary in vitro study

García-Lorenzana

2020

APH

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Introduction: Urine samples are one of the most frequently submitted samples for culture to clinical microbiology laboratories, exceeding the number of most of the other clinical sample types. Various non-antibiotic pharmaceutical compounds may have inhibitory properties on bacteria, as many of these agents accumlate in/eliminated through urine. Methods: Sixty (n=60) pharmacological agents were tested during our experiments. Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603 (ESBL-producing) and Staphylococcus aureus ATCC 29213 were the bacterial strains utilized in this study. Detection of inhibitory activity among the tested compounds was performed on Mueller-Hinton plates, using disk diffusion method. Results: Nineteen (n=19) compounds presented with various levels of inhibitory activity on the tested bacterial strains (four compounds for K. pneumoniae, seven compounds on E. coli and sixteen compounds on S. aureus). The compounds showed the highest levels of inhibitory activity on B. subtilis ATCC 6633, which is one of the main bacterial strains used for the screening of the ’intrinsic’ antibacterial activity of urine. Conclusion: Our results suggest that further experiments, involving additional pharmacological agents is warranted, to establish the full extent of their influence on the appropriate culture of urine samples.

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“…In particular, the majority of cases are caused by the Escherichia coli bacteria (about 90% of cases are caused by E. coli bacteria) because this bacterium is able to penetrate directly into the urinary tract or endoscopic surgery, in addition to E. coli, there are also bacteria such as Staphylococcus, Pseudomonas, Klebsiella, and Proteus 9 . It is important that recurrence is common 10 . Therefore, resistance to these bacterial strains can alleviate or prevent urinary tract infections.…”

Section: Research Articlementioning

confidence: 99%

Anti-urolithic, anti-inflammatory and anti-bacterial properties of various extracts from Musa balbisiana Colla fruits

Ly¹,

Le²,

Nguyen³

et al. 2021

Pharm Sci Asia

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Musa balbisiana fruits is an important and commonly used plant for its medicinal and pharmacological properties. Urolithiasis has become a very common clinical disease in over the world. The present study aimed to evaluate in vitro anti-urolithic, antiinflammatory, and antibacterial activities of crude and fractionated extracts of M. balbisiana fruits. The M. balbisiana fruit extracts were evaluated anti-urolithic property by nucleation and aggregation assays of calcium oxalate crystallization, anti-inflammatory activity by protein denaturation assay and red blood cell membrane stabilization, and antibacterial activity using the well diffusion agar method, minimum inhibitory concentration assay, and minimum bactericidal concentration assay. Results indicated that crude extract and different fractions had anti-urolithic, antibacterial, and anti-inflammatory activities. Chloroform fraction had the highest ability against calcium oxalate crystals formation with an IC50 value of 22.04 ± 1.09 µg/mL, which was comparable with sodium citrate (202.08 ± 18.46 µg/mL). In the active in against crystals aggregation, n-hexane fraction had the highest activity with an IC50 value of 414.77 ± 10.85 µg/mL, whereas IC50 value of sodium citrate was 1390.33 ± 92.66 µg/mL. Furthermore, crude and fractionated extracts presented anti-inflammatory activity through inhibition protein denaturation and red blood cells membrane stabilization. Simultaneously, the crude extract and different fractions exhibited the ability to against E. coli, P. aeruginosa, and S. aureus. Taken together, the present study had demonstrated that M. balbisiana fruits has properties that support urolithiasis disease.

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Recurrent urinary tract infections: a critical review of the currently available treatment options

Cited by 11 publications

References 43 publications

Association between Biofilm-Production and Antibiotic Resistance in Uropathogenic Escherichia coli (UPEC): An In Vitro Study

Association between Biofilm-Production and Antibiotic Resistance in Uropathogenic Escherichia coli (UPEC): An In Vitro Study

Non-antibiotic compounds affecting the growth of urinary pathogens during urine culture: a preliminary in vitro study

Anti-urolithic, anti-inflammatory and anti-bacterial properties of various extracts from Musa balbisiana Colla fruits

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