Recurrent Toxic Hepatitis in a Caucasian Girl Related to the Use of Shou‐Wu‐Pian, a Chinese Herbal Preparation

Panis, Bianca; Wong, Dennis R.; Hooymans, P. M.; Smet, Peter A. G. M. De; Rosias, Philippe

doi:10.1097/01.mpg.0000164699.41282.67

Cited by 66 publications

(67 citation statements)

References 24 publications

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“…Polygonum multiflorum is one form of TCM, and is sold as a food supplement to improve immune function and enhance hair growth through its antioxidant properties (Wong et al, 2006). However, adverse reactions induced by P. multiflorum are common, with patients developing drug-induced liver injury (DILI) and even liver failure (Mazzanti et al, 2004;Panis et al, 2005;Cárdenas et al, 2006;Jung et al, 2011). Although the mechanism is unknown, many studies have suggested that an idiosyncratic reaction occurs, which is related to genetic polymorphisms in various enzymes (Empey, 2010).…”

Section: Introductionmentioning

confidence: 99%

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

Ma¹,

Zhang²,

Jia³

2014

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to evaluate the genotype and allelic frequencies of CYP1A2 in Chinese patients with acute liver injury induced by Polygonum multiflorum. We examined the clinical mechanism of acute liver injury induced by P. multiflorum. According to the diagnostic criteria for drug-induced liver injury (DILI), 43 cases of P. multiflorum-induced liver injury admitted to the First Affiliated Hospital, Zhejiang University were identified between January 2008 and December 2012. An additional 43 control subjects were also chosen. Several alleles, including *1C, *1F, *2, *7, *9, and *11 of CYP1A2 were amplified from genomic DNA and sequenced. We used the chi-square test to determine whether CYP1A2 allele polymorphisms are associated with acute liver injury induced by P. multiflorum. The frequency of the CYP1A2 *1C allele was 46.5% in P. multiflorum-induced DILI patients, which was significantly different from the frequency of 27.9% observed in healthy subjects. The frequency of the CYP1A2*1F allele was 63.9% in P. multiflorum-induced DILI patients, compared to 57.0% in healthy controls; the difference was not significant. The allelic frequencies of CYP1A2*2, CYP1A2*7, CYP1A2*9, and CYP1A2*11 were too low to be detected. The frequency of the CYP1A2*1C mutation in Chinese patients with P. multiflorum-induced acute liver injury differed from that in healthy Chinese people, indicating that CYP1A2*1C is probably related to metabolism of P. multiflorum, which is followed by acute liver injury.

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Section: Introductionmentioning

confidence: 99%

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

Ma¹,

Zhang²,

Jia³

2014

Genet. Mol. Res.

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“…She also recovered after cessation of the herbal product (125). Additionally, Panis et al (119) reported the first case of Shou-Wu-Pian inducing hepatotoxicity in pediatric. A 5-year-old girl presented with acute liver injury twice related to Shou-Wu-Pian product.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…Moreover, Shou-Wu-Pian is another common Chinese herbal mixture. ShouWu-Pian preparation is formulated from the root of Polygonum multiflorum plant (fleece flower root), which is a common Chines herb that belongs to Polygonaceae family (113,119). ShouWu-Pian is alternatively known as He-Shou-Wu and Mr. Black Hair (119,120).…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…ShouWu-Pian preparation is formulated from the root of Polygonum multiflorum plant (fleece flower root), which is a common Chines herb that belongs to Polygonaceae family (113,119). ShouWu-Pian is alternatively known as He-Shou-Wu and Mr. Black Hair (119,120). The roots and vines of P. multiflorum have been used as a tonic for treating several conditions including backache, constipation, dizziness, greying of hair, spermatorrhea, lumbago and treating symptoms of chronic prostatitis (120,121,122).…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…Another reported case of hepatotoxicity involved a 17-week pregnant woman who consumed Shou-Wu-Pian for treating hair loss. She presented with jaundice and diagnosed with acute toxic hepatitis (119). Moreover, a 78-yearold male used Shou-Wu-Pian for the treatment of chronic prostatitis and developed acute hepatitis.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

See 2 more Smart Citations

Hepatotoxic Botanicals - An Evidence-based Systematic Review

Abdualmjid

Sergi

2013

J Pharm Pharm Sci

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-Purpose. Herbal medicines have been increasingly used worldwide. However, the potential harms of these herbs have been noticed most recently following hepatotoxicity with ingestion of herbal remedies. The aim of this review is to evaluate the evidence of hepatotoxic effects linked to use of herbal preparations. Method. Electronic search was performed by searching several databases: PubMed, HerbMed, Google Scholar, Scopus, Cochrane Database of Systematic Reviews and Cochrane Library using both Latin and common names of several herbs. Language was restricted to English and articles were selected for relevance reporting incidence of hepatotoxicity associated with use of herbal products in human. Results. From a total of 565 relevant reviews and articles, 254 met our inclusion criteria and were analyzed.

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Adverse Drug Reactions and Pharmacovigilance of Herbal Medicines

Barnes

2011

Stephens' Detection and Evaluation of Adverse Drug Reactions

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Recurrent Toxic Hepatitis in a Caucasian Girl Related to the Use of Shou‐Wu‐Pian, a Chinese Herbal Preparation

Cited by 66 publications

References 24 publications

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

Hepatotoxic Botanicals - An Evidence-based Systematic Review

Adverse Drug Reactions and Pharmacovigilance of Herbal Medicines

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