Recurrent Tenosynovial Giant Cell Tumor (TGCT) in Thumb Treated by Excision and Adjuvant 3DCRT Radiation

Jerome, J. Terrence Jose; Sofia, Loganathan Rajesh; Santhi, Natesan

doi:10.1007/s43465-022-00665-w

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…This type of tumor originates from synovial cells or mesenchymal cells differentiated into synovial cells ( 1 ). TGCT can be classified into two types: localized and diffuse ( 2 ). The localized type includes Giant Cell Tumor of the Tendon Sheath (GCTTS) and Localized Pigmented Villonodular Synovitis (PVNS), while the diffuse type includes Conventional Pigmented Villonodular Synovitis and Diffuse Giant Cell Tumor ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…TGCT can be classified into two types: localized and diffuse (2). The localized type includes Giant Cell Tumor of the Tendon Sheath (GCTTS) and Localized Pigmented Villonodular Synovitis (PVNS), while the diffuse type includes Conventional Pigmented Villonodular Synovitis and Diffuse Giant Cell Tumor (2). Most GCTTS occur in the small joints of the hands and feet, but they can also affect other joints or non-joint areas (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Zhang,

Zeng,

Liu

et al. 2024

Front. Oncol.

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Tendon Sheath Giant Cell Tumor (TGCT) is a benign tumor that primarily grows within joints and bursae. However, it has a high postoperative recurrence rate, ranging from 15% to 45%. Although radiotherapy may reduce this recurrence rate, its applicability as a standard treatment is still controversial. Furthermore, the pathogenic mechanisms of TGCT are not clear, which limits the development of effective treatment methods. The unpredictable growth and high recurrence rate of TGCT adds to the challenges of disease management. Currently, our understanding of TGCT mainly depends on pathological slice analysis due to a lack of stable cell models. In this study, we first reviewed the medical records of two female TGCT patients who had undergone radiotherapy. Then, by combining bioinformatics and machine learning, we interpreted the pathogenesis of TGCT and its associations with other diseases from multiple perspectives. Based on a deep analysis of the case data, we provided empirical support for postoperative radiotherapy in TGCT patients. Additionally, our further analysis revealed the signaling pathways of differentially expressed genes in TGCT, as well as its potential associations with osteoarthritis and synovial sarcomas.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Zhang,

Zeng,

Liu

et al. 2024

Front. Oncol.

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Ultrasound as a Diagnostic Modality in Hand and Wrist Musculoskeletal Pathologies: A Narrative Review

Jerome

2024

JOIO

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Diffuse Tenosynovial Giant Cell Tumor of the Wrist with Joint Destruction and Invasion

Jerome,

Dhanalakshmi,

Lavanya

2023

Journal of Arthroscopy and Joint Surgery

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A 54-year-old man took antitubercular drugs for 1 year for right wrist pain, swelling, and restriction of movements, with no improvements. Magnetic resonance imaging wrist reported multiple nodules and soft-tissue mass with intraosseous erosions involving carpal bones, distal radius, and ulna. Resection of the mass, excision of the distal ulna, and wrist arthrodesis were done. The histopathology confirmed a diffuse tenosynovial giant cell tumor (TSGCT). No postoperative radiotherapy or systemic therapies were given. The patient remained symptom-free at 2 years of follow-up. Diffuse TSGCT with joint destruction and invasion of the wrist is rare. Therefore, a high index of suspicion is required before considering the most common infective etiologies in the wrist.

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Recurrent Tenosynovial Giant Cell Tumor (TGCT) in Thumb Treated by Excision and Adjuvant 3DCRT Radiation

Cited by 3 publications

References 8 publications

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Ultrasound as a Diagnostic Modality in Hand and Wrist Musculoskeletal Pathologies: A Narrative Review

Diffuse Tenosynovial Giant Cell Tumor of the Wrist with Joint Destruction and Invasion

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