Recurrent Takotsubo Cardiomyopathy: Getting to the Root of the Problem

Tunzi, Matthew; Dinkha, Laith; Sharp, Alec; Gore, Rosco

doi:10.12659/ajcr.923067

Cited by 6 publications

(11 citation statements)

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“…With limited research on prevention of this rare phenomenon, study reports have demonstrated modification of psychological/emotional triggers as a way to prevent TCM recurrence with positive results using cognitive–behavioural therapy and serotonin selective reuptake inhibitors 21. Our patient was discharged home after her first episode with lisinopril and carvedilol, in accordance with the 2018 international expert consensus of TCM.…”

Section: Discussionmentioning

confidence: 68%

Recurrent biventricular takotsubo cardiomyopathy with fatal outcome

et al. 2022

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A woman in her 60s presented initially with nausea, vomiting and abdominal pain. She rapidly progressed to respiratory failure requiring intubation. ECG demonstrated no significant ST segment changes. Troponin I and brain natriuretic peptide were elevated. Chest CT angiography demonstrated small non-occlusive segmental pulmonary emboli. Transthoracic echocardiogram findings suggested biventricular takotsubo cardiomyopathy (TCM) with left ventricular ejection fraction of less than 20%. She improved with aggressive management and was discharged on carvedilol, lisinopril, atorvastatin and apixaban. Follow-up echocardiogram revealed complete resolution of the left and right ventricular wall motion abnormalities at 9 weeks. She had symptoms recurrence after 7 months from the initial presentation. Repeated echocardiogram was consistent with biventricular TCM recurrence. Despite aggressive medical therapy, multiorgan failure developed and patient care was later transitioned to palliative care.

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Section: Discussionmentioning

confidence: 68%

Recurrent biventricular takotsubo cardiomyopathy with fatal outcome

et al. 2022

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“…This could be concerning given that SSRIs are widely used in the United States [ 26 ]. Alternatively, SSRI and cognitive behavioral therapy were arguably suggested as a treatment for patients with recurrent stress cardiomyopathy [ 27 ]. Further research is needed to shed more light on such an association.…”

Section: Discussionmentioning

confidence: 99%

Transient Mid-Ventricular Ballooning Syndrome: An Atypical Variant of Stress Cardiomyopathy

Takla¹,

Mahmoud²,

Mostafa³

et al. 2023

Cureus

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Takotsubo cardiomyopathy, also known as stress cardiomyopathy (SCM) or broken heart syndrome, is characterized by transient systolic dysfunction of the left ventricle (LV). It typically affects the apical segment, but several rare variants exist. This report represents a rare variant of atypical stress cardiomyopathy that mimics territorial regional wall motion abnormalities of a blocked epicardial vessel.

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“…Further research can be deployed in assessment methods exploring novel biomarkers as well as the likes of sST-2, GDF-15, and the BNP-to-CKMB ratio 35,42,43 . Like most conditions, prevention of TTS may stem from psychiatric interventions like cognitive behavioural therapy aiming to address the root cause, as anxiety and depression are prevalent in this patient cohort 64 …”

Section: Cardiac Imagingmentioning

confidence: 99%

An update on takotsubo syndrome

Alim,

Shah,

Zahera

et al. 2023

Journal of Cardiovascular Medicine

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Takotsubo syndrome (TTS) can be described as an acute, transiently occurring form of heart failure. It typically causes systolic dysfunction of the left ventricle (LV). Perhaps what is of most significance is the reversible nature of TTS, with many patients achieving recovery within a few weeks to months. TTS can be referred to by other names, attributed to its various precipitants, as well as the structural manifestations of the syndrome. Physical and emotional stressors have been identified as the most common of causes, hence the terms ‘stress cardiomyopathy’ and ‘broken heart syndrome’. Precipitants can range from psychological, and hormonal, to molecular mechanisms. The symptoms of TTS can coalesce with other conditions and hence give rise to many differential diagnoses. Most patients present with dyspnoea and chest pain. The latter also presents in acute coronary syndrome (ACS); thus, ACS is a common differential diagnosis for TTS. The coronavirus disease 2019 (COVID-19) pandemic saw a drastic increase in mental health concerns which have persisted beyond this period. Further studies into personality disorders and their potential predisposition to COVID-19 and thus TTS would advance our understanding of the neuropsychiatric triggers of TTS. There is also a need for a single sensitive and specific diagnostic test for TTS as its diagnosis relies on the culmination of clinical presentation, echocardiography, cardiac catheterization, and cardiovascular magnetic resonance imaging (CMR).

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Recurrent Takotsubo Cardiomyopathy: Getting to the Root of the Problem

Cited by 6 publications

References 0 publications

Recurrent biventricular takotsubo cardiomyopathy with fatal outcome

Recurrent biventricular takotsubo cardiomyopathy with fatal outcome

Transient Mid-Ventricular Ballooning Syndrome: An Atypical Variant of Stress Cardiomyopathy

An update on takotsubo syndrome

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