Recurrent synovitis of hip and MEFV gene related arthritis in children

Abstract

Background: Recurrent and relapsing arthritis has been proposed to describe a group of arthritis with recurring and periodic nature, in which the joints are intermittently involved. This study reports three non-FMF patients with heterozygous MEFV gene mutations and an extraordinary arthritis as a recurrent synovitis of hip (RSH). Methods: During 16-years from 2003 to 2019 at pediatric rheumatologic clinic among 195 recorded files with chronic oligoarthritis, 3 patients with diagnosis of recurrent synovitis of hip (RSH) were reviewed thoroughly. Peripheral blood was collected from patients and the samples were screened for the 12 common MEFV gene pathogenic variants. Results: This study included three patients, two female and one male with relapsing idiopathic arthritis that has been located on hip joints as a sole manifestation and pathologic findings of MEFV mutations as follow: A744S, V726A, and R761H. Conclusion: On the basis of possible role of MEFV gene in different rheumatic disease, MEFV gene related arthritis may be considered as a background of RSH particularly in Mediterranean area.

Evaluation of efficacy and safety of traditional Chinese medicine in the treatment of hip synovitis in children

“…Clinically, since children do not cooperate with the clinical examination of doctors, it will lead to the clinical examination of doctors is not careful enough, easily missed and misdiagnosed, resulting in serious consequences. [1,[18][19][20] TCM has extensive experience in treating synovitis of the hip joint in children, and the efficacy is significant. This is the first meta-analysis of the efficacy and safety of TCM for the treatment of hip synovitis in children, and we hope that this will facilitate the development and use of TCM to better treat patients.…”

“…Synovitis of the hip joint in children is an acute orthopedic disease with a short disease course, benign, and can be completely cured, and the effusion can be completely absorbed. Clinically, since children do not cooperate with the clinical examination of doctors, it will lead to the clinical examination of doctors is not careful enough, easily missed and misdiagnosed, resulting in serious consequences [1,18–20] …”

“…With an incidence of approximately 3:1 in men and women, it is self-limiting and is the most common cause of hip pain in children aged 3 to 8 years. [1,2] Its etiology has not been fully determined until now and is generally considered as temporary hip pain and dysfunction. Caused by bacterial or viral infection, hip joint damage, excessive fatigue, allergy, and so on.…”

“…Synovitis of the hip in children is a non-specific inflammatory change of the hip, with transient acute pain, swelling, and effusion as the main clinical manifestations. With an incidence of approximately 3:1 in men and women, it is self-limiting and is the most common cause of hip pain in children aged 3 to 8 years [1,2] . Its etiology has not been fully determined until now and is generally considered as temporary hip pain and dysfunction.…”