“…Like most implantable medical devices, interference fixation devices are prone to microbial contamination and colonization [ 19 , 20 ], leading to the occurrence of biofilm-associated infections which cause moderate-to-severe complications that, ultimately, may lead to ligament reconstruction failure [ 21 ]. Biofilms are multicellular, surface-associated microbe communities surrounded by self-produced extracellular polymeric substances (EPSs) that provide protection for bacterial cells—thus rendering them resistant to conventional biocide/biostatic treatments—and the host’s immune response [ 22 , 23 , 24 , 25 , 26 ].…”