Recurrent superficial cellulitis‐like erythema associated with Helicobacter cinaedi bacteremia

Adachi, Yuko; Moriya, Chie; Fujisawa, Tomomi; Shu, En; Kanoh, Hiroyuki; Nakayama, Asami; Yonetamari, Jun; Seishima, Mariko

doi:10.1111/1346-8138.13282

Cited by 5 publications

(5 citation statements)

References 5 publications

(6 reference statements)

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“…As H. cinaedi resides in the gastrointestinal tract, lesions such as colonic perforation, cholecystectomy, or diarrhea can weaken the mucosal barrier and promote the development of bacteremia . An infection with H. cinaedi results in diverse clinical manifestations with cellulitis and fever as the most common ones, although arthritis, infection of abdominal aortic aneurysm, intrauterine infections, pyogenic spondylitis and diskitis, erythema, vertebral osteomyelitis, and liver cirrhosis are also described. These manifestations are mostly seen in immunocompromised patients, but immunocompetent patients are also susceptible .…”

Section: Helicobacter Cinaedi: An Emerging Pathogen In Human Patientsmentioning

confidence: 99%

“…45 An infection with H. cinaedi results in diverse clinical manifestations with cellulitis [44][45][46][47][48] and fever 44,45,[48][49][50][51][52] as the most common ones, although arthritis, 46 infection of abdominal aortic aneurysm, 53,54 intrauterine infections, 49 pyogenic spondylitis and diskitis, 50 erythema, 44,51 vertebral osteomyelitis, 55,56 and liver cirrhosis 42 are also described. These manifestations are mostly seen in immunocompromised patients, 42,45,47,48,51,52,55 but immunocompetent patients are also susceptible. 46,49,50,53,54,56,57 Originally, H. cinaedi was described as Campylobacter-like organism 1, isolated from homosexual men with enterocolitis.…”

Section: Helicobacter Cinaedi: An Emerging Pathogen In Human Patientsmentioning

confidence: 99%

“…59 Up till now, no susceptibility testing guidelines or standard therapy is available. 50 Based on MIC values 42,47,49,53,56,57 and/or empiric observations, 44,45,51,52,54,55 H. cinaedi seems to be susceptible to beta-lactam antibiotics, 42,44,45,47,[49][50][51][52][53][54][55][56][57] aminoglycosides, 49,54 and tetracyclines. 47,51-53,55-57 A long-term therapy of 2-8 weeks is recommended.…”

Section: Helicobacter Cinaedi: An Emerging Pathogen In Human Patientsmentioning

confidence: 99%

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Other Helicobacters and gastric microbiota

et al. 2016

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This article aimed to review the literature from 2015 dealing with gastric and enterohepatic non-Helicobacter pylori Helicobacter species (NHPH). A summary of the gastric microbiota interactions with H. pylori is also presented. An extensive number of studies were published during the last year and have led to a better understanding of the pathogenesis of infections with NHPH. These infections are increasingly reported in human patients, including infections with H. cinaedi, mainly characterized by severe bacteremia. Whole-genome sequencing appears to be the most reliable technique for identification of NHPH at species level. Presence of NHPH in laboratory animals may influence the outcome of experiments, making screening and eradication desirable. Vaccination based on UreB proteins or bacterial lysate with CCR4 antagonists as well as oral glutathione supplementation may be promising strategies to dampen the pathogenic effects associated with gastric NHPH infections. Several virulent factors such as outer membrane proteins, phospholipase C-gamma 2, Bak protein, and nickel-binding proteins are associated with colonization of the gastric mucosae and development of gastritis. The development of high-throughput sequencing has led to new insights in the gastric microbiota composition and its interaction with H. pylori. Alterations in the gastric microbiota caused by the pH-increasing effect of a H. pylori infection may increase the risk for gastric cancer.

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Section: Helicobacter Cinaedi: An Emerging Pathogen In Human Patientsmentioning

confidence: 99%

Section: Helicobacter Cinaedi: An Emerging Pathogen In Human Patientsmentioning

confidence: 99%

Section: Helicobacter Cinaedi: An Emerging Pathogen In Human Patientsmentioning

confidence: 99%

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Other Helicobacters and gastric microbiota

et al. 2016

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“…It has been revealed that H. cinaedi bacteremia is sometimes accompanied by skin eruptions. Most of the previously reported skin eruptions developed with fever [ 4 , 10 , 11 , 12 , 13 , 14 , 15 ]. These skin eruptions were considered to be secondary bacterial involvement of the skin through hematogenous spread from the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Fever due to Helicobacter cinaedi Infection during R-CHOP Chemotherapy in Diffuse Large B-Cell Lymphoma: Case Report and Literature Review

et al. 2021

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Fever due to Helicobacter cinaedi bacteremia under chemotherapy has not been widely recognized among clinicians. We experienced a 72-year-old man with diffuse large B-cell lymphoma, who was complicated with H. cinaedi bacteremia-induced fever under R-CHOP chemotherapy. We summarized 6 cases including ours, suggesting that fever without neutropenia developing around day 6 from starting chemotherapy is a possible symptom caused by H. cinaedi bacteremia. We should discriminate fever due to H. cinaedi bacteremia if fever emerged before myelosuppression in the course of chemotherapy.

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“…XLA has also been associated several inflammatory and autoimmune diseases 1 such as arthritis, inflammatory bowel disease, and, more recently, eosinophilic fasciitis. 2 Helicobacter cinaedi is reportedly involved in several cutaneous manifestations ranging from cellulitis 3 , 4 to superficial ulcers on erythematous, eroded plaques. 5 We report a case of H cinaedi bacteremia mimicking eosinophilic fasciitis in a patient with XLA.…”

Section: Introductionmentioning

confidence: 99%