Recurrent spontaneous abortion and selenium deficiency

Koçak, İ̇dris; Aksoy, Esra; Üstün, Cazıp

doi:10.1016/s0020-7292(99)00022-3

Cited by 32 publications

(14 citation statements)

References 2 publications

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“…Selenium (Se) is an essential cofactor for the antioxidant enzyme glutathione peroxidase. Although two studies found significant decreases in serum Se among women who miscarried as compared to women with normal pregnancies, 67,68 a larger case-control study did not confirm this association. 69 A review of the epidemiologic literature suggests that paternal exposure to lead or mercury may be associated with an increased risk of SAB.…”

Section: Trace Elementsmentioning

confidence: 79%

The Epidemiology of Recurrent Pregnancy Loss

2000

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In reviewing the epidemiology of recurrent abortion (RAB), we believe it is necessary to consider the epidemiology of spontaneous abortion (SAB) as well, since it is clear that even a single pregnancy loss increases the risk for a subsequent abortion. In addition, any attempt to identify epidemiologic risk factors for SAB or RAB must deal with the fact that at least 50% of SABs are associated with genetic abnormalities. Given that most epidemiologic studies have not distinguished karyotypically abnormal abortuses, risk factors are likely to be underestimated. Nevertheless, there is fair agreement that a variety of factors may increase risk for SAB or RAB, including advanced maternal age, single gene mutations such as PKU or G6PD deficiency, structural abnormalities of the uterus, poorly controlled diabetes, antiphospholipid syndrome, and smoking. More controversial is the role of luteal phase defect or hyperandrogenism, alloimmune factors, genital infections, caffeine or alcohol use, and trace element or chemical exposure from tap water or in the workplace. Besides better designed epidemiologic studies to detect modifiable risk factors for SAB or RAB, there is a clear need for clinical trials of therapy for RAB which meet minimum epidemiologic standards including randomization, double-blinded (when possible), and placebo-controlled (when ethical).

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Section: Trace Elementsmentioning

confidence: 79%

The Epidemiology of Recurrent Pregnancy Loss

2000

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“…[54] and Turkey (55 ± 17 versus 81 ± 16 μ g/L, resp.) [55]. It has therefore been suggested that reduced selenium concentration results in reduced glutathione peroxidase activity culminating in reduced antioxidant protection of biological membranes and DNA during the early stages of embryonic development [54, 56].…”

Section: Methodsmentioning

confidence: 99%

The Importance of Antioxidant Micronutrients in Pregnancy

Mistry

Williams

2011

Oxidative Medicine and Cellular Longevity

184

188

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Pregnancy places increased demands on the mother to provide adequate nutrition to the growing conceptus. A number of micronutrients function as essential cofactors for or themselves acting as antioxidants. Oxidative stress is generated during normal placental development; however, when supply of antioxidant micronutrients is limited, exaggerated oxidative stress within both the placenta and maternal circulation occurs, resulting in adverse pregnancy outcomes. The present paper summarises the current understanding of selected micronutrient antioxidants selenium, copper, zinc, manganese, and vitamins C and E in pregnancy. To summarise antioxidant activity of selenium is via its incorporation into the glutathione peroxidase enzymes, levels of which have been shown to be reduced in miscarriage and preeclampsia. Copper, zinc, and manganese are all essential cofactors for superoxide dismutases, which has reduced activity in pathological pregnancy. Larger intervention trials are required to reinforce or refute a beneficial role of micronutrient supplementation in disorders of pregnancies.

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“…Two of the 4 published studies investigating the association of selenium status with recurrent abortion indicated no significant differences in the levels between patients and controls (37,69). Two of the studies reported significantly lower levels of selenium in the recurrent abortion group (38,70). There is no conclusive evidence for selenium supplementation in recurrent abortion because of the drawback of the small sample size of the studies and the conflicting results.…”

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confidence: 99%

The Role of Oxidative Stress in Spontaneous Abortion and Recurrent Pregnancy Loss: A Systematic Review

Gupta¹,

Agarwal²,

Banerjee³

et al. 2007

Obstetrical &Amp; Gynecological Survey

273

203

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After completion of this article, the reader should be able to state that the causes of spontaneous and recurrent abortion are multifaceted, however, some of the causes may be preventable and also explain that the role of oxidative stress during pregnancy and adverse pregnancy outcomes has a basis in pathophysiology, although the role of oxidative stress and the treatment of oxidative stress during or before pregnancy remains speculative.

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Recurrent spontaneous abortion and selenium deficiency

Cited by 32 publications

References 2 publications

The Epidemiology of Recurrent Pregnancy Loss

The Epidemiology of Recurrent Pregnancy Loss

The Importance of Antioxidant Micronutrients in Pregnancy

The Role of Oxidative Stress in Spontaneous Abortion and Recurrent Pregnancy Loss: A Systematic Review

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