Recurrent Skin Cancer

Freeman, Robert G.

doi:10.1001/archderm.1973.01620180049015

Cited by 48 publications

(15 citation statements)

References 14 publications

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“…Moreover, our study pointed out the eventuality of a change-over in the histological pattern from the primary lesion to the recurrent lesion. Indeed, sclerodermiforme characteristics that were absent in the primary lesion were present in 37.9% of the recurrent lesions: this was a frequent finding (57.1% of recurrences) and it is in accordance with other reports in the literature (18), although few studies on this subject have been published. These findings support the hypothesis that recurrent lesion are biologically different entities characterized by greater aggressiveness than primary lesions.…”

Section: Discussionsupporting

confidence: 90%

“…In our experience, the timeline of recurrence we observed suggests that a follow-up period of at least 3 years is adequate. Consistent with reports from other authors (13,17,18), this management should allow for the early detection of recurrence and ensure more conservative treatment strategies at least in 3/4 of the cases. When the margins were found to be infiltrated, the recurrence rate reached more than 50% within 12 months from excision and 90% within 36 months.…”

Section: Discussionsupporting

confidence: 79%

“…Moreover, recurrence rates reported for primary BCCs 5 years after complete excision account for 99% of cases of Mohs microsurgery, about 95% for traditional surgical excision, radiotherapy or cryosurgery and almost 92% with DTC (16). Conversely, the recurrence rate for incompletely excised BCC varies from 10 to 67% (12,13,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Notwithstanding, the great disparity and variability in recurrence rates reported by different authors have contributed to the lack of an accepted Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies agreement concerning the optimal therapeutic strategy to adopt in those cases in which histological examination shows an infiltration of surgical margins or a suboptimal margin free from disease.…”

Section: Introductionmentioning

confidence: 99%

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Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies

Sartore

Lancerotto²,

Salmaso³

et al. 2011

Oncol Rep

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Abstract. Rates of recurrence after incomplete surgical excision of basal cell carcinoma (BCC) range from 4 to 16.6% of analyzed cases. The aim of the present study was to identify the predictive factors associated with facial BBC recurrence following excision and their influences, in order to establish a proper therapeutic strategy. A monocentric retrospective study was performed reviewing all BCCs surgically excised at the Institute of Plastic Surgery, University of Padua, with particular focus on the involvement of surgical margins and recurrence. Seven hundred and nineteen lesions in 605 patients were studied. Correlations between recurrence probability and various characteristics of BCC were analyzed using a logistic regression model. It was observed that incomplete excision, deep margin involvement, the presence of sclerodermiform or metatypic basaloid squamous cells, as well as pleomorphous histological variants and/or peritumoral inflammatory infiltrates, were all related to an increase in the probability of recurrence. BCC excision must be followed by individualized management with particular consideration for the localization, the histological type and other known predisposing factors; the treatment strategy and, in particular, the length of the surveillance period and the frequency of patient assessment should be evaluated on the basis of the recurrence probability outlined.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies

Sartore

Lancerotto²,

Salmaso³

et al. 2011

Oncol Rep

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“…8,[13][14][15][16] It has been reported that the metastatic rate of poorly differentiated lesions is almost triple that of well-differentiated lesion and that the 5-year cure rate for well-differentiated lesions is far superior to the cure rate for poorly differentiated lesions. Some authors believe that poorly differentiated tumors metastasize more frequently (Figures 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors for Metastasis in Squamous Cell Carcinoma of the Skin

Cherpelis

Marcusen

Lang

2002

Dermatologic Surgery

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background. Squamous cell carcinoma (SCC) of the skin exhibits a significant propensity to metastasize. A number of variables have been reported to influence the tendency of SCC to metastasize. Because of the increasing incidence of skin cancer, it is becoming increasingly important to identify those neoplasms which are biologically more aggressive. We report 25 cases of metastatic SCC and compare them to 175 cases of nonmetastasizing SCC treated during the same period. objective. To characterize tumors with the greatest tendency to metastasize. methods. A tumor registry from the Dermatologic Surgery Unit at the Medical University of South Carolina was accessed to obtain records on 200 patients diagnosed with invasive SCC managed by Mohs surgery from 1988 to 1998. A retrospective analysis was conducted. The characteristics of patients with metastatic SCC and those with nonmetastatic SCC were compared using the chi-squared test and Fisher's exact test. results. Of 200 tumors, 25 (12.5%) metastasized. Size, Clark's level, degree of differentiation, the presence of small tumor nests, infiltrative tumor strands, single-cell infiltration, perineural invasion, acantholysis, and recurrence all correlated strongly with metastasis. Location, ulceration, inflammation, and Breslow depth did not correlate with the development of metastasis. conclusion. Patients with tumors that exhibit certain clinical and histologic features are more likely to metastasize and need close follow-up to detect recurrence and metastasis early, allowing for appropriate life-saving intervention. Sentinel lymph node biopsy should be considered in patients with high-risk SCC.

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“…Treated recurrent tumors have a significantly higher 5-year recurrence rate than treated primary tumors. 4,33 Recurrent tumors possess an "aggressive," sclerotic histological appearance 34,35 in which the original histological pattern is seen superficially, while a more aggressive subtype with narrow, invasive strands within a dense, fibrous stroma can be seen deeper. 36 Thus, inadequate treatment may play a role in converting a relatively benign cutaneous lesion into a more biologically aggressive, invasive, and destructive tumor that is more difficult to eradicate.…”

Section: Are Recurrence Rates the "Gold Standard" For Choosing A Treamentioning

confidence: 99%