Recurrent respiratory papillomatosis: A state-of-the-art review

Fortes, Helena Ribeiro; Ranke, Felipe Mussi von; Escuissato, Dante L.; Neto, César Augusto Araujo; Zanetti, Gláucia; Hochhegger, Bruno; Souza, Carolina A.; Marchiori, Edson

doi:10.1016/j.rmed.2017.03.030

Cited by 169 publications

(240 citation statements)

References 24 publications

Supporting

Mentioning

216

Contrasting

Unclassified

Order By: Relevance

“…Guidance for daily practice situations and the subsequent action that can be taken are shown in Table …”

Section: Methodsmentioning

confidence: 99%

“…AGW can become large during pregnancy 5 but will usually disappear within weeks of delivery. In rare cases, HPV can be transmitted during child birth resulting in recurrent respiratory papillomatosis in the infant 73 Diagnosis and management of AGW Imiquimod 5% or 3.75% Imiquimod is an immune response modifier with antiviral activity. This Toll-like receptor 7 agonist induces the production of cytokines, which enhance the ability of antigen presenting cells to present viral antigens to reactive T lymphocytes.…”

Section: Immunotherapiesmentioning

confidence: 99%

“…16 Smoking cessation should be encouraged Pregnancy • Explain that pregnancy is an immune suppressed state and therefore wart infections can become large during pregnancy but will usually disappear within weeks of delivery 76 • During pregnancy, the warts should not be treated if they do not represent an obstacle to delivery. If needed, only use ablative methods, e.g., cryotherapy or trichloroacetic acid 3,12,50 • Avoid extensive laser vaporization, electrocautery or surgery during the 6-8 weeks before delivery • Be aware that in rare cases, HPV can be transmitted during child birth resulting in recurrent respiratory papillomatosis in the infant 73,78 Immune suppression • Establish the patient's HIV status • Check to see whether they are on immunosuppressive drugs for inflammatory bowel disease, rheumatoid arthritis etc.…”

Section: Heavy Cigarette Smokingmentioning

confidence: 99%

“…Guidance for daily practice situations and the subsequent action that can be taken are shown in Table 4. 3,8,12,16,23,26,30,50,54,56,62,66,[72][73][74][75][76][77][78][79][80] Preventing AGW Anogenital warts can now be effectively prevented using the quadrivalent (HPV 6, 11, 16 and 18) or nanovalent (HPV 6, 11, 16, 18, 31, 33, 45, 52 and 58) HPV vaccines; these protect against HPV types that cause AGW, cervical cancer and other types of anogenital and oral cancer. The HPV quadrivalent vaccine has shown to be up to 100% effective in preventing AGW in association with vaccine-type HPV in women.…”

Section: Guidance For Daily Practice Situationsmentioning

confidence: 99%

See 3 more Smart Citations

Position statement for the diagnosis and management of anogenital warts

O'Mahony

Gomberg

Skerlev

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Anogenital warts ( AGW ) can cause economic burden on healthcare systems and are associated with emotional, psychological and physical issues. Objective To provide guidance to physicians on the diagnosis and management of AGW . Methods Fourteen global experts on AGW developed guidance on the diagnosis and management of AGW in an effort to unify international recommendations. Guidance was developed based on published international and national AGW guidelines and an evaluation of relevant literature published up to August 2016. Authors provided expert opinion based on their clinical experiences. Results A checklist for a patient's initial consultation is provided to help physicians when diagnosing AGW to get the relevant information from the patient in order to manage and treat the AGW effectively. A number of frequently asked questions are also provided to aid physicians when communicating with patients about AGW . Treatment of AGW should be individualized and selected based on the number, size, morphology, location, and keratinization of warts, and whether they are new or recurrent. Different techniques can be used to treat AGW including ablation, immunotherapy and other topical therapies. Combinations of these techniques are thought to be more effective at reducing AGW recurrence than monotherapy. A simplified algorithm was created suggesting patients with 1–5 warts should be treated with ablation followed by immunotherapy. Patients with >5 warts should use immunotherapy for 2 months followed by ablation and a second 2‐month course of immunotherapy. Guidance for daily practice situations and the subsequent action that can be taken, as well as an algorithm for treatment of large warts, were also created. Conclusion The guidance provided will help physicians with the diagnosis and management of AGW in order to improve the health and quality of life of patients with AGW .

show abstract

“…Guidance for daily practice situations and the subsequent action that can be taken are shown in Table …”

Section: Methodsmentioning

confidence: 99%

Section: Immunotherapiesmentioning

confidence: 99%

Section: Heavy Cigarette Smokingmentioning

confidence: 99%

Section: Guidance For Daily Practice Situationsmentioning

confidence: 99%

See 2 more Smart Citations

Position statement for the diagnosis and management of anogenital warts

O'Mahony

Gomberg

Skerlev

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Pathologic Features.-Papillomas of the airway may be sessile or papillary, consisting of stratified layers of maturing squamous cells surrounding a fibrovascular core (74,79,80) (Figs 10, 11). Maturation of the epithelial cells is delayed but orderly from the basal layers to the surface, resulting in thickening of the basal cell layers and nucleated cells in the superficial layer (74).…”

Section: Recurrent Respiratory Papillomatosismentioning

confidence: 99%

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Lichtenberger¹,

Biko²,

Carter³

et al. 2018

RadioGraphics

View full text Add to dashboard Cite

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Among these tumors, imaging findings such as air-filled cysts in type 1 PPB and homogeneously low attenuation of fetal lung interstitial tumors are relatively specific. Key pathologic and genetic discriminators among this group of tumors include the DICER1 germline mutation found in PPB and the t(12,15)(p13;q25) translocation and ETV6-NTRK3 fusion gene seen in infantile fibrosarcoma. Primary lung tumors in older children include inflammatory myofibroblastic tumors (IMTs), carcinoid salivary gland-type tumors of the lung, recurrent respiratory papillomatosis, and other rare entities. IMT, a spindle-cell proliferation with inflammatory elements, is the most common lung tumor in children. Anaplastic lymphoma kinase, a receptor-type protein tyrosine kinase, is present in 50% of these tumors, and this finding may support an imaging diagnosis of IMT. Carcinoid tumors account for a substantial portion of childhood lung tumors, and their characteristic avid enhancement on images corresponds to the compressed fibrovascular stroma histologically. Furthermore, novel imaging agents used with somatostatin receptor analogs have an emerging role in the evaluation of carcinoid tumors. Although less common than mucoepidermoid carcinoma, adenoid cystic carcinoma tends to recur given the perineural spread seen histologically. Integrating radiologic and pathologic knowledge is critical to accurate diagnosis, treatment planning, and surveillance of primary lung tumors in children.Abbreviations: CPAM = congenital pulmonary airway malformation, FDG = fluorodeoxyglucose, FLIT = fetal lung interstitial tumor, GLUT1 = glucose transporter 1, IMT = inflammatory myofibroblastic tumor, NUT = nuclear protein in testis, PPB = pleuropulmonary blastoma, RRP = recurrent respiratory papillomatosis

show abstract

Exophytic Laryngeal Mass

Landsberger

Liu

Barbu

2022

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

A 29-year-old Pakistani woman was referred to the otolaryngology clinic for increased postnasal drip, pharyngitis, odynophagia, cervicalgia, cervical lymphadenopathy, and rightsided otalgia that had persisted for more than a week. She was breastfeeding her 10-monthold, had no history of alcohol use, and had a remote history of hookah use. She was a Southern California native with travel history to Pakistan, Turkey, Jordan, Israel, Qatar, and Dubai 5 years prior to symptom onset. One month prior to onset, she drove from Los Angeles, California, to Houston, Texas. She denied recent unintentional weight loss, cough, fever, night sweats, chills, stridor, dyspnea, dysphonia, or rash.On examination, her vital signs were within normal limits, and physical examination revealed a small right tonsillolith, mild tonsillar erythema that was worse on the right side, and a mobile 2-cm, right level 2 lymph node that was slightly tender to palpation. Laboratory evaluation was notable for an elevated eosinophil count and positive Epstein-Barr immunoglobulin G. Her white blood cell count and mononucleosis spot test result were within normal parameters.Her symptoms persisted despite treatment with penicillin, azithromycin, and steroids from her primary physician and amoxicillin-clavulanate, sinus rinses, fluticasone propionate, and azelastine spray from an otolaryngologist to treat any contributing postnasal drainage and tonsillitis.Flexible transnasal videolaryngoscopy revealed a lesion on the laryngeal surface of the right epiglottis passing midline extending to the right aryepiglottic fold, but not involving the true vocal cords (Figure 1A). Given inconclusive office biopsy results, direct laryngoscopy with biopsy was performed, showing extensively inflamed squamous mucosa with ulceration, granulation tissue, pseudoepitheliomatous hyperplasia, and atypia (Figure 1B).

show abstract

Recurrent respiratory papillomatosis: A state-of-the-art review

Cited by 169 publications

References 24 publications

Position statement for the diagnosis and management of anogenital warts

Position statement for the diagnosis and management of anogenital warts

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Exophytic Laryngeal Mass

Contact Info

Product

Resources

About