Recurrent renal cell carcinoma after 45 years

Tapper, Helene; Klein, Harold P.; Rubenstein, W A; Intriere, Lisa; Choi, Young Don; Kazam, Elias

doi:10.1016/s0899-7071(96)00042-3

Cited by 32 publications

(29 citation statements)

References 17 publications

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“…This observation was also confirmed in a further, small study (n = 16), in which the mean survival time for patients with isochronous lung metastasis was 24 months and for patients with metachronous metastasis 43 months [18]. In isolated cases, extremely long metachronous intervals of up to 45 years have been reported for secondary, pulmonary metastasis [10,19]. Nevertheless, for the approximately 500 cases which have so far been described in the literature, the importance of DFI cannot be considered as conclusive.…”

Section: Lung Metastasessupporting

confidence: 52%

Operative Therapy in Disease Progression and Local Recurrence of Renal Cell Carcinoma

Fischer

Schmid²

1999

Urol Int

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When local recurrence or distant metastasis occurs, the question arises as to which therapeutic concept should be applied. In contrast to the data on systemic immunotherapy, there are no systematic studies on surgical management of metastasis. Local recurrence (a rare condition) is frequently resected, whereby a prolongation of life can be achieved in individual cases. The complete surgical resection of pulmonary metastases has been shown, in a number of studies, to achieve a survival rate of 5 years in up to 44% of the cases. There are only few data regarding resection of osseous metastases; although in this respect some studies have reported an average survival rate of 34 months, the indication for this condition has, up to now, usually been seen as palliative. The prognosis of liver or brain metastasis is unfavorable; the survival rates achieved with the help of surgical procedures are scarcely higher than those resulting from the spontaneous progression of metastatic renal carcinoma (12 months). Thus, there is an urgent need for further studies in order to define the indication for the surgical management of metastasis.

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Section: Lung Metastasessupporting

confidence: 52%

Operative Therapy in Disease Progression and Local Recurrence of Renal Cell Carcinoma

Fischer

Schmid²

1999

Urol Int

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“…In single cases, late recurrences were observed even decades after nephrectomy [2,5,6]. The longest reported interval between nephrectomy and local recurrence is 45 years [6]. Herein we report a case with successful surgical treatment of multiple lung metastases (9 and 20 years after nephrectomy) and resection of locally recurrent tumor (20 years after nephrectomy).…”

Section: Introductionmentioning

confidence: 92%

“…Late tumor recurrence is reported to occur in about 11% of the 10-year survivors [2]. In single cases, late recurrences were observed even decades after nephrectomy [2,5,6]. The longest reported interval between nephrectomy and local recurrence is 45 years [6].…”

Section: Introductionmentioning

confidence: 99%

Late Local and Pulmonary Recurrence of Renal Cell Carcinoma

Froehner¹,

Manseck²,

Lossnitzer

et al. 1998

Urol Int

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“…[1] The incidence of late recurrence is 11% in patients surviving for 10 years and the longest interval to recurrence reported is 45 years. [5,6] Long term survival rates of 21-44% have been documented following curative resection for RCC metastases at various sites. [7] Metastases from renal cell carcinoma can be diagnosed in virtually any location, but they commonly spread to the lung (75%), regional lymph nodes (60-65%), bones (20%), liver (18%), skin (8%), and central nervous system (8%).…”

Section: Discussionmentioning

confidence: 99%

22-year survival following radical nephrectomy and several metastasectomies in a case of renal cell carcinoma

Yücel

Tunç

Başaran

et al. 2017

Turkish Journal of Urology

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Renal cell carcinoma (RCC) is a common malignancy. Metastases can be seen both synchronously, at the time of diagnosis, and metachronously during follow-up. At the time of diagnosis, 23% of the patients have metastatic disease. and 25% of patients will develop metastasis during follow-up period after nephrectomy. Nearly 80% of them develop within the first 5 years. However late metastasis of RCC have been also reported within the postoperative 10 years in the literature. For metastatic lesions, if surgically feasible, metastasectomy, and targeted pharmaceutical agents have been recommended. However any randomized controlled study which aimed to determine treatment protocol in patients who develop multiple metastases has not been cited in the literature. Herein, we are presenting a case with renal cell carcinoma in whom within 22 years of follow-up after 10 years of survival multiple metastases in different organs were detected which were managed with surgical, and medical treatments. As far as we know, this case is the first patient with the longest survival whose non-pulmonary metastases had been treated with more than one surgical interventions.

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Recurrent renal cell carcinoma after 45 years

Cited by 32 publications

References 17 publications

Operative Therapy in Disease Progression and Local Recurrence of Renal Cell Carcinoma

Operative Therapy in Disease Progression and Local Recurrence of Renal Cell Carcinoma

Late Local and Pulmonary Recurrence of Renal Cell Carcinoma

22-year survival following radical nephrectomy and several metastasectomies in a case of renal cell carcinoma

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