Recurrent rectal cancer: diagnosis with dynamic MR imaging.

Müller-Schimpfle, Markus; Brix, Gunnar; Layer, G.; Schlag, P. M.; Engenhart, R.; Frohmüller, S.; Heß, Thomas; Zuna, I.; Semmler, W.; Kaick, G. van

doi:10.1148/radiology.189.3.8234720

Cited by 105 publications

(39 citation statements)

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“…To validate our interpretation regarding the (path0)physiological meaning of the model parameters A and kZl, we have started to correlate our M R findings with detailed histological analysis in ongoing trials. An extensive discussion concerning the relation between the model parameters and histological observations in colorectal cancer can be found in a paper by Miiller-Schimpfle et al (28). It should be mentioned, however, that a pharmacokinetic model is not the system itself, but rather an abstraction of it that emphasizes those aspects that the investigator feels to be important.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Mapping of the Breast: A New Method for Dynamic MR Mammography

Hoffmann

Brix

Knopp

et al. 1995

Magnetic Resonance in Med

289

227

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A dynamic contrast-enhanced MRI technique for whole breast examinations is presented. The fast kinetics of tissue response during and after constant-rate intravenous infusion of gadolinium diethylenetriaminopentaacetic acid was resolved using a strongly T1-weighted saturation recovery TurboFLASH sequence that makes it possible to acquire signal-time courses sequentially from 15 adjacent slices with a temporal sampling rate of 21 s. On the basis of the mathematically established and experimentally verified linear relationship between the measured saturation recovery TurboFLASH signal variation and the gadolinium diethylenetriaminopentaacetic acid concentration in the tissue, the signal-time courses were analyzed within the framework of pharmacokinetic modeling. In our study, the tissue response was parameterized adequately using an open linear two-compartment model. With this approach, the tissue specific information contained in the signal-time course can be described using only two parameters: an amplitude A, reflecting the degree of MR signal enhancement, and an exchange parameter k21, characterizing vascular permeability and perfusion of the tissue. A clearly arranged representation of the large amount of data (480 saturation recovery TurboFLASH breast images/examination) was accomplished by means of color coding of the computed parameters, resulting in one color-coded pharmacokinetic parameter map/cross-section.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Mapping of the Breast: A New Method for Dynamic MR Mammography

Hoffmann

Brix

Knopp

et al. 1995

Magnetic Resonance in Med

289

227

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“…The values of CEA scintigraphy and dynamic MR imaging have also been evaluated (Muller-Schimpfle et al, 1993;Blomqvist et al, 1996;Jarv et al, 2000;Torricelli et al, 2003). In the field of MR contrast agents, the usefulness of ferromagnetic colloidal particles coated with methacrylate copolymers coupled to antibodies has been reported (Renshaw et al, 1986a).…”

Section: Igg-ferumoxidesmentioning

confidence: 99%

Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma

et al. 2005

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Superparamagnetic iron oxide (SPIO)-based colloid has been used clinically as a tissue-specific magnetic resonance contrast agent. We coupled monoclonal antibody A7 (Mab A7), which reacts specifically with human colorectal carcinoma, to Ferumoxides (SPIO) and examined the accumulation of this conjugate in xenografted tumours in nude mice. We examined in vitro immunoreactivity of Mab A7 coupled to Ferumoxides and its in vivo distribution in nude mice with human colorectal carcinoma. Magnetic resonance imaging of tumour-bearing nude mice was performed 72 h after injection of A7-Ferumoxides. A7-Ferumoxides retained binding activities that were nearly identical to intact Mab A7. More of the radiolabelled A7-Ferumoxides accumulated in the tumour than normal mouse IgG-Ferumoxides from 12 h onwards after injection (Po0.05). Both A7-Ferumoxides and normal mouse IgGFerumoxides disappeared from blood linearly over time. The accumulation levels in normal tissue decreased linearly over time but were lower than levels in tumours from 6 h. In magnetic resonance T2-weighted imaging of the tumour-bearing nude mice, signal intensity was reduced at the margin of the tumour by injection of A7-Ferumoxides. Mab A7 coupled to Ferumoxides is potentially suitable as a magnetic resonance contrast agent for detecting local recurrence of rectal carcinoma.

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“…All subsequent models reported in the literature presented variations of these three principal models without radically changing the underlying methodology. Pharmacokinetic analysis of DCE-MRI was applied to the assessment of breast cancer [15][16][17], cervical cancer [18], colorectal cancer [19] and heart disease [20][21][22].…”

mentioning

confidence: 99%

Measurement of pharmacokinetic parameters in histologically graded invasive breast tumours using dynamic contrast-enhanced MRI

Radjenovic

Dall²,

Ridgway³

et al. 2008

BJR

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This document is the author deposited version. You are advised to consult the publisher's version if you wish to cite from it. Published versionRADJENOVIC, A., DALL, B. J., RIDGWAY, J. P. and SMITH, M. A. (2008). Measurement of pharmacokinetic parameters in histologically graded invasive breast tumours using dynamic contrast-enhanced MRI. British Journal of Radiology, 81 (962), 120-128. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 This paper presents a practical clinical application of a quantitative pharmacokinetic model to study histologically confirmed and graded invasive human breast tumours. The hypothesis was that, given a documented difference in capillary permeability between benign and malignant breast tumours, a relationship between permeability-related DCE-MRI parameters and tumour aggressiveness persists within invasive breast carcinomas. In addition, it was hypothesised that pharmacokinetic parameters may demonstrate stronger correlation with prognostic factors than the more conventional black-box techniques, so a comparison was undertaken. Copyright and re-use policySignificant correlations were found between pharmacokinetic and black-box parameters in 59 invasive breast carcinomas. However, statistically significant variation with tumour grade was only demonstrated in two permeability related pharmacokinetic parameters: k ep (p<0.05) and K trans

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Recurrent rectal cancer: diagnosis with dynamic MR imaging.

Abstract: Pharmacokinetic mapping of dynamic MR imaging data allows in vivo insight into tissue physiopathology, helping differentiate benign from malignant pelvic lesions in rectal cancer.

Cited by 105 publications

References 0 publications

Pharmacokinetic Mapping of the Breast: A New Method for Dynamic MR Mammography

Pharmacokinetic Mapping of the Breast: A New Method for Dynamic MR Mammography

Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma

Measurement of pharmacokinetic parameters in histologically graded invasive breast tumours using dynamic contrast-enhanced MRI

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