Recurrent pyogenic liver abscess as a presenting manifestation of colorectal cancer

Kim, Hee Yeon; Kim, Chang Wook; Kim, Dong Ryul; Cho, Young Wook; Cho, Jae-Young; Kim, Woo Jung; Choi, Hyung Gyu

doi:10.3904/kjim.2015.301

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…La infección hepática y formación de absceso por E. vermicularis es extremadamente rara, se han registrado menos de 10 casos en la literatura; de estos, aproximadamente 5 casos se han descrito en pacientes con cáncer colorrectal e infección hepática que simulan metástasis hepáticas en los estudios imagenológicos (2)(3)(4)6,7) .…”

Section: Discussionunclassified

Absceso hepático por Enterobius vermicularis como diagnóstico diferencial de metástasis hepática en cáncer colorrectal, reporte de caso

Romo¹,

Venegas

López³

et al. 2022

Rev. colomb. Gastroenterol.

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Introducción: el cáncer colorrectal es la cuarta causa de mortalidad asociada con cáncer en el mundo. La identificación de las metástasis de este tumor en el momento prequirúrgico es cada vez más frecuente por los estudios imagenológicos con los que se cuenta en la actualidad. Presentamos el caso de una paciente con infección por Enterobius vermicularis que simula la presencia de metástasis hepáticas. Presentación del caso: se presenta el caso de una paciente femenina proveniente del área rural, con dolor abdominal de 1 año de evolución asociado con hemorragia de vías digestivas bajas y pérdida de peso. Las imágenes y estudios endoscópicos muestran una lesión tumoral en el colon sigmoide con biopsias que reportan adenocarcinoma de colon sigmoides, además de lesiones hepáticas sugestivas de malignidad. Se llevó a resección anterior de recto y sigmoides con anastomosis alta y toma de biopsias hepáticas, que descartaron la malignidad e informaron la presencia de infección hepática por E. vermicularis. Discusión: La infección por E. vermicularis a nivel hepático presentada en el caso es poco frecuente, dicha infección puede simular la presencia de metástasis hepáticas, por lo cual debe tenerse en cuenta como diagnóstico diferencial de enfermedad metastásica de cáncer colorrectal.

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Section: Discussionunclassified

Absceso hepático por Enterobius vermicularis como diagnóstico diferencial de metástasis hepática en cáncer colorrectal, reporte de caso

Romo¹,

Venegas

López³

et al. 2022

Rev. colomb. Gastroenterol.

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“…The association between CRC and K. pneumoniae PLA has been demonstrated. [10][11][12] As revealed in an 11-year follow-up study in Taiwan, patients with PLA caused by K. pneumoniae had a significantly greater rate (adjusted hazard ration = 2.68) of subsequent CRC than those with non-K. pneumoniae PLA. 10 K. pneumoniae can asymptomatically reside in the gastrointestinal (GI) tract and subsequently spreads to other organs, causing extraintestinal infections.…”

Section: Introductionmentioning

confidence: 96%

Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

et al. 2021

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Sequence type (ST) 11 is one of the major lineages of carbapenem-resistant Klebsiella pneumoniae (CRKP). Although the gastrointestinal (GI) carriage of CRKP predisposes individuals to subsequent infections, little is known for its impact on gut homeostasis. In this study, we investigated the association between ST11 CRKP colonization and colorectal cancer (CRC). Two ST11 CRKP, KPC160111 (KL47) and KPC160132 (KL64), were selected as the representative strains. We used azoxymethane (AOM) and dextran sodium sulfate (DSS) to initiate a colitis-associated CRC model. Both strains established prolonged colonization in the GI tract of the AOM-DSS-treated BALB/c mice and aggravated gut dysbiosis. Under this AOM-DSS-induced setting, ST11 K. pneumoniae colonization significantly promoted the growth and progression of colorectal adenomas to high-grade dysplasia. Numerous crypts were formed inside the enlarged adenomas, in which CD163 + tumor-associated macrophages accumulated. Similarly, ST11 K. pneumoniae also increased the population size of the CD163 + macrophages with the M2 phenotype in the peritoneal cavity of LPS-primed BALB/c mice. When applied to RAW264.7 cells, ST11 K. pneumoniae polarized the macrophages toward an M2 phenotype through the inhibition of IKK-NFκB and the activation of STAT6-KLF4-IL-10. Through the M2-skewing ability, ST11 K. pneumoniae promoted the accumulation of CD163 + macrophages in the adenomatous crypts to create an immunosuppressive niche, which not only accommodated the extended stay for its own sake but also deteriorated colorectal tumorigenesis.

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“…This phenomenon has also been observed in E. coli , where reports demonstrated colibactin genotoxin’s ability to cleave host DNA double strands bringing about cell cycle arrest as well as DNA damage and mutations which initiates tumorigenesis [ 7 ]. This is pertinent, as an 11-year retrospective study conducted on PLA patients revealed that K. pneumoniae PLA patients had approximately three times higher risk of developing colorectal cancer (CRC) years after a PLA infection compared to non- K. pneumoniae PLA patients [ 8 , 9 , 10 , 11 , 12 ]. The common notion indicates PLA as a precursor disease and a risk factor of CRC development which is the second most common cancer diagnosed worldwide irrespective of gender.…”

Section: Introductionmentioning

confidence: 99%

Presence of Polyketide Synthase (PKS) Gene and Counterpart Virulence Determinants in Klebsiella pneumoniae Strains Enhances Colorectal Cancer Progression In-Vitro

et al. 2023

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Klebsiella pneumoniae (K. pneumoniae) colonizes the human gut and is a causative factor of pyogenic liver abscess (PLA). Retrospective studies conducted on K. pneumoniae PLA patients revealed subsequent CRC development in later years of their life with increasing prevalence of these strains harbouring polyketide synthase (PKS) genes. To our knowledge there are no known studies directly implicating K. pneumoniae with CRC to date. Our aims are to characterize K. pneumoniae isolates from CRC patients and investigate its effects on cell proliferation in vitro. K. pneumoniae isolates were characterized by screening virulence genes including polyketide synthase (PKS), biofilm assay, antibiotic susceptibility, and string test to determine hypervirulent (hvKp) strains. Solubilised antigens of selected K. pneumoniae isolates were co-cultured with primary colon cell lines and CRC cell lines (Stage I-IV) for 48 h. The enhancement of proliferation was measured through MTT and ECIS assay. Twenty-five percent of K. pneumoniae isolates were PKS-positive out of which 50% were hvKp strains. The majority of the isolates were from the more virulent serotype of K1 (30%) and K2 (50%). PKS-positive K. pneumoniae isolates did not possess genes to confer carbapenem resistance but instead were more highly associated with siderophore genes (aerobactin, enterobactin, and yersiniabactin) and allantoin metabolism genes (allS, allS2). Cell proliferation in primary colon, SW1116 (Stage I), and SW480 (Stage II) CRC cell lines were enhanced when co-cultured with PKS-positive K. pneumoniae antigens. ECIS revealed enhanced cell proliferation upon recurrent antigen exposure. This demonstrates the possible role that PKS-positive K. pneumoniae has in exacerbating CRC progression.

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Recurrent pyogenic liver abscess as a presenting manifestation of colorectal cancer

Cited by 7 publications

References 5 publications

Absceso hepático por Enterobius vermicularis como diagnóstico diferencial de metástasis hepática en cáncer colorrectal, reporte de caso

Absceso hepático por Enterobius vermicularis como diagnóstico diferencial de metástasis hepática en cáncer colorrectal, reporte de caso

Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

Presence of Polyketide Synthase (PKS) Gene and Counterpart Virulence Determinants in Klebsiella pneumoniae Strains Enhances Colorectal Cancer Progression In-Vitro

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