Recurrent Pancreatitis in Gardner Variant Familial Polyposis

Wright, Brian D.; Kozarek, Richard A.; Traverso, L. William; Wechter, Debra G.; Thirlby, Richard C.; Raltz, Shirley L.

doi:10.1001/archsurg.134.3.311

Cited by 13 publications

(2 citation statements)

References 19 publications

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“…Acute pancreatitis is sometimes associated with gastrointestinal polyposis syndrome [9, 10, 11]. These reports describe obstructive acute pancreatitis caused by ampullary masses related to gastrointestinal polyposis syndrome.…”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis Secondary to Duodenoduodenal Intussusception in Duodenal Adenoma

Watanabe¹,

Noda²,

Okamura³

et al. 2012

Case Rep Gastroenterol

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Duodenoduodenal intussusception is a rare condition that is in general caused by a tumor. We describe duodenoduodenal intussusception secondary to a tubulovillous adenoma that caused acute pancreatitis in a 31-year-old female. We resected a duodenal tumor from the submucosal layer and then simply closed the duodenal wall. To the best of our knowledge, this is the first description of acute pancreatitis secondary to duodenoduodenal intussusception by tubulovillous adenoma in the second part of the duodenum in an adult.

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Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis Secondary to Duodenoduodenal Intussusception in Duodenal Adenoma

Watanabe¹,

Noda²,

Okamura³

et al. 2012

Case Rep Gastroenterol

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“…Although the condition is technically not a congenital pancreaticobiliary variant, a subset of Gardners patients develop not only pancreatic and peripancreatic neoplasm, but also relapsing pancreatitis. Our group reported eight such patients, all of whom had undergone prior colectomy, and four of whom had had a previous cholecystectomy [25]. The pancreatitis was related to ampullary adenomas in five of these patients, and was presumably related to pancreas divisum in one case; it was a consequence of bile duct stones in one case, and idiopathic in one case.…”

Section: Therapeutic Pancreatic Endoscopymentioning

confidence: 95%

Therapeutic Pancreatic Endoscopy

2001

Endoscopy

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Therapeutic endoscopy in pancreatitis has included biliary or pancreatic sphincterotomy, or both, for microlithiasis and sphincter dysfunction. Alternatively, endoscopic treatment has been used to treat ductal disruption, including external or internal fistulas (high amylase effusions, pancreatic ascites, pancreaticoenteric communications, or pseudocysts). Finally, endoscopy has been used to treat obstructive disease, including both stones and strictures. This article reviews the state of the art in this field over the past year. Unfortunately, this is an area in which the appropriate approaches are still poorly defined, and prospective studies randomly assigning patients to endoscopic treatment in comparison with medical or surgical therapy remain few and far between.

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Efficacy of endoscopic retrograde cholangiopancreatography in familial adenomatous polyposis patients after duodenectomy

et al. 2022

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Objectives Familial adenomatous polyposis (FAP) patients with Spigelman stage IV polyposis should be considered for prophylactic duodenectomy. Post‐surgical pancreaticobiliary complications occur and may require management via endoscopic retrograde cholangiopancreatography (ERCP). We aimed to assess the success and adverse events of ERCP in FAP patients after pancreas‐sparing duodenectomy (PSD) and pancreaticoduodenectomy (PD). Methods A retrospective review of FAP patients who underwent ERCP after PSD or PD from 1992 to 2020 at a quaternary referral center was completed. The technical success of ERCP was defined as the ability to identify the anastomosis and cannulate the duct. Post‐procedural adverse events were defined by bleeding, perforation, pancreatitis, or cholangitis. Clinical outcomes included the need for surgical intervention and recurrent pancreatitis after ERCP were assessed. Results Of 84 FAP patients with duodenectomy, 12 patients with PSD and two patients with PD underwent 17 ERCPs for pancreatic indications and five for biliary indications. The technical success of ERCP in patients with PSD and a single neoampullary complex for pancreatic ( n = 6) and biliary ( n = 5) indications was 100% but for those with PD ( n = 2) or PSD reconstruction with pancreatic divisum or separate anastomoses ( n = 3), it was 0%. Surgical intervention was required in 50% of patients with technically failed ERCP after PSD (2/4) and PD (1/2). There were no adverse events. Conclusions ERCP is expected to be therapeutically successful for biliary complications following PSD. Assessment and potential therapy for pancreatitis post‐PSD are best in the setting of a single neo‐ampullary complex rather than in PD or PSD with pancreatic divisum.

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Recurrent Pancreatitis in Gardner Variant Familial Polyposis

Cited by 13 publications

References 19 publications

Acute Pancreatitis Secondary to Duodenoduodenal Intussusception in Duodenal Adenoma

Acute Pancreatitis Secondary to Duodenoduodenal Intussusception in Duodenal Adenoma

Therapeutic Pancreatic Endoscopy

Efficacy of endoscopic retrograde cholangiopancreatography in familial adenomatous polyposis patients after duodenectomy

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