“…Children with RAP often have at least one parent who also suffers from FAP (14,16,18); (iv) paroxysmal trend and heterogeneous symptoms, with clinical features that may suggest severe organic pathology: a differential diagnosis is needed by instrumental examinations (3,(20)(21)(22); (v) risk of life-time duration (18,(23)(24)(25); (vi) burden on the quality of life and high (personal and familial) costs (6,17,(26)(27)(28)(29); (vii) influences of psychological triggering factors (3,6,8,(29)(30)(31); (viii) parental characteristics and response to childhood pain (18,26,27). Poor family atmosphere: severe familial disorder, stress, conflict or tension at home (3,26,30,32,33); (ix) common personality characteristics: fearful of novelty, prone to separation concerns, shy and withdrawn (3,27,(34)(35)(36); (x) psychiatric comorbidity: mainly anxiety and depression (8,16,18,37,38); (xi) a role for serotonin has been suggested in both conditions (4,(38)…”