Recurrent Neutrophilic Dermatosis of the Face—a Variant of Sweet's Syndrome

Whittle, C. H.; Beck, Geoffrey; Champion, R.H.

doi:10.1111/j.1365-2133.1968.tb11950.x

Cited by 60 publications

(28 citation statements)

References 5 publications

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“…The cause of Sweet's syndrome is not clear, but a hypersensitivity reaction to some antigen such as bacterial antigen was suspected in the pathogenesis [2,3]. There also exists a variant form of Sweet's syndrome known as recurrent neutrophilic dermatosis of the face, which was first described by Whittle et al [4] in 1968. Dis tinctive characteristics of this variant compared with Sweet's syndrome are the lack of general symptoms and the localization of the skin lesion to the face.…”

mentioning

confidence: 99%

Atypical Neutrophilic Dermatosis on the Upper Extremity Affected by Postmastectomy Lymphedema: Report of 2 Cases

Demitsu¹,

Tadaki

1991

Dermatology

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We describe 2 female patients, both with a history of radical mastectomy for breast cancer, in whom several indurated erythematous plaques developed on the upper extremity affected by postmastectomy lymphedema. There were no general symptoms or leukocytosis. Histopathological examination showed a dense neutrophilic infiltrate without a feature of vasculitis in the dermis and subcutis. Dramatic therapeutic response was observed to treatment with potassium iodide. These findings resemble Sweet’s syndrome, but such cases have not been previously reported. Possible pathogenic mechanisms for these unique cutaneous eruptions are discussed.

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mentioning

confidence: 99%

Atypical Neutrophilic Dermatosis on the Upper Extremity Affected by Postmastectomy Lymphedema: Report of 2 Cases

Demitsu¹,

Tadaki

1991

Dermatology

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“…Two cases, characterized by strict confinement of lesions to the face with recurrence of facial lesions in varied distributions, were described. 4 Since then, further cases of localized Sweet's syndrome have been documented, with initial diagnoses of facial cellulitis, 5,6 facial erysipelas 7 or eruptive xanthoma. 8 A further localized variant of Sweet's syndrome, 'neutrophilic dermatosis of the dorsal hands', was proposed as a subtype of Sweet's syndrome given multiple case series of patients with corticosteroid responsive eruptions limited to the dorsa of the hands and fingers.…”

Section: Discussionmentioning

confidence: 98%

Facial Sweet’s syndrome mimicking rosacea fulminans

Anavekar

Williams

Chong³

2007

Aust J Dermatology

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A 36-year-old man presented with a non-pruritic, erythematous facial rash with peri-oral and peri-orbital sparing. The initial clinicopathological diagnosis was rosacea fulminans, which was treated with 25 mg oral prednisolone and cephalexin. The patient re-presented 1 week later with exacerbation of his rash in addition to constitutional symptoms of fever and malaise. A further skin biopsy was taken and the marked neutrophilic infiltrate in the absence of vasculitis made the diagnosis of Sweet's syndrome (acute febrile neutrophilic dermatosis). High-dose prednisolone (50 mg daily), topical hydrocortisone cream and ichthammol in zinc ointment were commenced with rapid clinical improvement. This case highlights the importance of considering Sweet's syndrome as a differential diagnosis when presented with a facial eruption.

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“…This presentation was later given its eponymous title by Whittle et al [2]. SS can present at any age, but most patients at the time of diagnosis are between 30 to 60 years of age, with 80 percent being women [3].…”

Section: Discussion:-mentioning

confidence: 99%