Recurrent meningeal sarcoma successfully treated with stereotactic radiosurgery

Cummings, Michael; Chowdhry, Varun Kumar; Shah, Hemangini; Back, Jason; Kennedy, Gloria A.

doi:10.3171/2012.8.peds12212

Cited by 10 publications

(12 citation statements)

References 15 publications

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“…In general, primary meningeal sarcomas are a rare group of intracranial malignant mesenchymal neoplasms without strong evidence-based treatment guidelines [23]. Among these few primary brain sarcomas, 70% arise in the pediatric population and there have been limited cases reported in adults [1].…”

Section: Discussionmentioning

confidence: 99%

“…Inherently, these tumors are not radiosensitive and the role of chemotherapy is not yet well established, though is usually attempted. Therefore, an aggressive surgical excision remains the mainstay of therapy [3]. The biological behavior of these lesions is largely unknown and recurrence and metastatic formation is a known phenomena [4].…”

Section: Discussionmentioning

confidence: 99%

“…These lesions are believed to originate from mesenchymal precursors of mesodermal and ectodermal origin, and rapid growth often produces mass effect on the brain. Diagnosis is rendered pathologically following resection, but MRI can reveal initial findings suggestive of meningeal sarcomas [3]. The infiltrative nature of these tumors and the dense adhesions to neighboring structures such as major vessels make surgical excision a difficult task.…”

Section: Introductionmentioning

confidence: 99%

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Seeding of Meningeal Sarcoma Along a Surgical Trajectory on the Scalp

Woo

Soo

Sup

2016

Brain Tumor Res Treat

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Primary sarcomas of the central nervous system are rare. These tumors is rapid growth often produces mass effect on the brain. Diagnosis is rendered pathologically after resection. Surgical resection is the mainstay treatment and need the adjuvant therapy. We report a 44-year-old female with a meningeal sarcoma of frontal meninges. She complained headache for 2 months and palpable forehead mass for 3 weeks. Brain MRI demonstrated a soft tissue mass sized as 5.3×3.7×3.1 cm with well-defined osteolysis on the midline of the frontal bone. The mass attached to anterior falx without infiltration into the brain parenchyme. The tumor had extracranial and extraaxial extension with bone destruction. The tumor was totally removed with craniectomy and she had an adjuvant radiotherapy. However, an isolated subcutaneous metastasis developed at the both preauricular area of the scalp, originating from the scar which was remained the first surgery. After complete removal of this metastasis, she had an adjuvant radiotherapy in other hospital. However, she expired after six months after first surgery. We believe that the occurrence of tumor seeding at the site of incision in the scalp is related to using the fluid for irrigation after tumor resection and the same surgical instruments for the removal of the brain tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seeding of Meningeal Sarcoma Along a Surgical Trajectory on the Scalp

Woo

Soo

Sup

2016

Brain Tumor Res Treat

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“…Reports on paediatric PMS are limited to case reports or very small single-institutional series precluding a proper assessment of clinical course and ideal treatment plan [2][3][4][5][6][7][8][9][10][11][12]. The main presenting symptoms are related to tumour location, size and aggressiveness.…”

Section: Introductionmentioning

confidence: 99%

“…They are characterized by short clinical history, rapid deterioration and high recurrence after surgical resection. The mean 1-year survival rate is around 50% [2][3][4][5][6][7][8][9][10][11]. There is no guideline for treatment but total surgical resection and radiotherapy play an important role while the effectiveness of chemotherapy remains to be demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Primary meningeal sarcoma in children: a survey from the French Society of Pediatric Oncology (SFCE)

Almasoud¹,

Schmitt²,

Grill³

et al. 2018

Arch Clin Cases

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Objectives: To describe the outcome of primary meningeal sarcoma (PMS) in a pediatric population. Methods: We conducted a retrospective study on patients harbouring a PMS based on the French registry of paediatric tumours. Questionnaires were sent to all French paediatric oncologists. Data on patient characteristics and treatments were collected. Pathology and imaging were centrally reviewed. Results: Between August 1989 and May 2010, 12 patients from 6 French centres, aged 3 months to 14.5 years (mean: 3.3 years) were treated for a PMS. Mean follow-up was 12 years (range: 3 months to 24 years). Tumour locations were: frontal (3), parieto-occipital (2), parietal (1), temporal (1), occipital (1), thalamic (1), pontocerebellar angle (1), cerebellar tentorium (1), ambient cistern (1). No metastasis was observed. The firstline treatment was surgery in 10 cases, chemotherapy in 2. Resection was total in 6 cases, partial in 6. Central pathology review concluded to: high-grade undifferentiated sarcoma (8), chondrosarcoma (2), fibrosarcoma (1), myxoid desmoplastic tumour (1). Seven tumours were smaller than 5 cm in size. Eleven patients received 2 to 10 courses of chemotherapy (median: 5) but no response was observed. Four out of 6 patients for whom a total resection was performed were still alive at time of study, compared to 2 when only partial resection was possible. Four out of 6 patients who received radiotherapy are still alive, compared to 1 out of 4 patients without radiotherapy. The 5-year Event-Free Survival (EFS) and Overall Survival (OS) rates were 50%. The median EFS in case of total resection was 39 months versus 16 months in case of partial resection. Neither correlation was found between tumour size and location or between age at diagnosis and EFS/OS. Conclusions: We report the first multicentre case series describing clinical, radiological presentation and outcome of PMS in children. In this short series of very rare tumours, age and tumour size did not seem to be prognostic factors. Total resection and radiotherapy seem to be essential. The role of chemotherapy remains unclear.

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Clinical outcomes for pediatric patients receiving radiotherapy for solid tumor central nervous system metastases

Howard

Boyle

Marcus

et al. 2021

Pediatric Blood & Cancer

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Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use of whole-brain radiotherapy (WBRT) versus focal radiotherapy, including stereotactic radiosurgery or stereotactic radiotherapy, for these indications are limited. We report a single institution experience of 26 pediatric patients treated with radiotherapy for solid tumor CNS metastases without leptomeningeal disease. Focal radiotherapy (n = 10) was well tolerated and survival outcomes did not differ between patients treated with WBRT (n = 16) versus focal radiation, suggesting that focal radiotherapy may be considered for patients with limited CNS metastases.

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Recurrent meningeal sarcoma successfully treated with stereotactic radiosurgery

Cited by 10 publications

References 15 publications

Seeding of Meningeal Sarcoma Along a Surgical Trajectory on the Scalp

Seeding of Meningeal Sarcoma Along a Surgical Trajectory on the Scalp

Primary meningeal sarcoma in children: a survey from the French Society of Pediatric Oncology (SFCE)

Clinical outcomes for pediatric patients receiving radiotherapy for solid tumor central nervous system metastases

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