Recurrent meningeal inflammatory myofibroblastic tumor: A case report and literature review

Pascual-Gallego, María; Yus, Miguel; Jorquera, Manuela; Gonzalez-Mat, Alfredo; Ortega, Luís; Martinez-Martinez, Armando; Zimman, Horacio

doi:10.4103/0028-3886.125273

Cited by 8 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gallago et al studied all cases of recurrence in IMT-CNS and found 19 such instances in over 100 cases reviewed. 3 Going through their data, we noted that the PCG variants had higher chances of recurrence than the FHC variants, and 11 out of 19 (57.8%) patients were females. Twelve of the cases (63%) who showed recurrence had not undergone gross total resection as their primary modality of management.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Inflammatory myofibroblastic tumor of the pituitary: A case report

Sharma¹,

Jyothish²,

Kutty³

et al. 2020

Indonesian Journal of Neurosurgery

View full text Add to dashboard Cite

Introduction: Inflammatory myofibroblastic tumor (IMT), a subtype of inflammatory pseudotumor, is a rare cause of nonneoplastic sellar mass. IMTs have been reported in various anatomical locations of the body, but their presence in the Central Nervous System (CNS), especially in the pituitary gland, is rare. The objective of our case report is to analyze the basis of their mimicry, discuss their differential diagnosis, and review the literature related to inflammatory pseudotumors of the pituitary. Case presentation: A 45-year-old male presented in our hospital with chief complaints of severe headache since two months ago and blurring of vision since two weeks ago. On investigation, Magnetic Resonance Imaging (MRI) revealed a pituitary macroadenoma, which was compressing the optic chiasma and encasing the left internal carotid artery. The patient underwent endonasal endoscopic transsphenoidal excision of the pituitary lesion and became asymptomatic in the postoperative period. Histopathology reported the presence of spindle-shaped cells, inflammatory cells, respiratory epithelium lined tissue, and areas of necrosis suggestive of an inflammatory myofibroblastic tumor. Conclusion:In the following communication, we discuss this esoteric pseudotumor of the pituitary and its peculiarities in diagnosis and management as it can easily disguise itself as a pituitary macroadenoma on radiological investigations, thus hoodwinking the physician of its actual pathology. We also review the literature to perceive the best management protocols and prognostic factors by drawing parallels with IMT in other parts of the CNS. The differential diagnosis of inflammatory myofibroblastic tumors of the CNS is difficult and relies mainly on histological analysis.

show abstract

Section: Discussionmentioning

confidence: 89%

“…2 IMT-CNS is a rare entity, with only 100 cases being reported so far. 3 Most tumors arise from meningeal structures, though intracerebral and intraventricular lesions have been known to occur. 4 From our literature search, only 7 cases of intrasellar IMT have been reported until now (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of the pituitary: A case report

Sharma¹,

Jyothish²,

Kutty³

et al. 2020

Indonesian Journal of Neurosurgery

View full text Add to dashboard Cite

show abstract

“…While tumors with ALK gene rearrangements are readily considered a unique neoplastic category, histologically similar neoplastic lesions may lack this genetic alteration[ 6 ]. ALK expression is positive in nearly 50% of patients with IMT, especially in children, and is associated with local recurrence and distant metastasis[ 7 ]. However, in the literature we reviewed, only about 25% of cases were positive for ALK expression.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of the central nervous system: A case report

Su¹,

Guo²,

Wan³

et al. 2022

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND An inflammatory myofibroblastic tumor (IMT) occurring in the central nervous system is very rare, and thus its pathogenesis is unknown. This case report and literature review aimed to explore the pathogenesis, clinical features, imaging findings, pathological characteristics, immunohistochemical characteristics, diagnoses, treatments, and risks of postoperative recurrence of IMT in the central nervous system. CASE SUMMARY A 67-year-old woman was admitted to the hospital with an exophthalmic protrusion and double vision in the left eye that had persisted for 3 mo. Magnetic resonance imaging (MRI) showed a 2.4 cm × 1.3 cm heterogeneous large mass in the bottom of the left anterior cranial fossa, which was closely related to the dura mater. Before surgery, we suspected the mass to be meningioma. The entire mass was successfully removed under neuronavigation and electrophysiological monitoring, and postoperative pathology indicated an IMT with extensive infiltration of chronic inflammatory cells and scattered multinucleated giant cells. Head MRI at the 3-mo follow-up showed that the tumor at the bottom of left anterior cranial fossa had been completely resected without recurrence. CONCLUSION From the histological, immunohistochemical, and genetic analyses, the present case suggests that the pathogenesis of IMT-CNS is related to autoimmunity.

show abstract

“…After incomplete resection, 40% recurrence rate is seen within 2 years. [ 8 9 ] Recurrence rate after gross total resection for ALK-positive and ALK-negative cases is around 33% and 9%, respectively. Most recurrences in ALK-positive patients occur within 2 years after surgery.…”

Section: Discussionmentioning

confidence: 99%

Central nervous system inflammatory myofibroblastic tumor masquerading as chronic suppurative otitis media

Singhal¹,

Agarwal

Chawla³

et al. 2017

J Pediatr Neurosci

View full text Add to dashboard Cite

Inflammatory myofibroblastic tumor (IMT) is a rare tumor in the central nervous system (CNS), mostly being extracranial. Approximately 100 sporadic cases have been reported in the literature. The rarity of the tumor, its various histopathological characteristics, and its variable aggressive course render it difficult to diagnose and treat. IMT is generally a histological diagnosis which is rarely suspected preoperatively. It mimics other intracranial tumors such as giant cell tumor, hemangiopericytoma, anaplastic meningioma, plasmacytoma, and lymphoma. Rarely, it can present with a clinical picture which mimics a benign infective process, Rosai-Dorfman disease, or an idiopathic hypertrophic pachymeningitis. High index of suspicion is required as total resection of this lesion is mandatory to prevent recurrence. Here, we describe a case of a 10-year-old child which initially presented with clinical features mimicking chronic suppurative otitis media and radiological presentation of a small intracranial abscess. He was initially treated by an ENT surgeon who started him on intravenous antibiotics, but the patient was lost to follow up. He returned after 2 months with a large lesion at the same location. Histological examination revealed multiple spindle cells with plasma cells and lymphocytes scattered among these spindle cells. The spindle cells were immunopositive for smooth muscle actin and negative for epithelial membrane antigen, S100, and CD34.

show abstract

Recurrent meningeal inflammatory myofibroblastic tumor: A case report and literature review

Cited by 8 publications

References 0 publications

Inflammatory myofibroblastic tumor of the pituitary: A case report

Inflammatory myofibroblastic tumor of the pituitary: A case report

Inflammatory myofibroblastic tumor of the central nervous system: A case report

Central nervous system inflammatory myofibroblastic tumor masquerading as chronic suppurative otitis media

Contact Info

Product

Resources

About