Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy

Neven, Johannus; Kaa, Christine Hulsbergen–van der; Loonen, Jacqueline J.; Wilde, P.C.M. de; Merkx, Matthias A.W.

doi:10.1016/j.tripleo.2008.02.001

Cited by 59 publications

(61 citation statements)

References 7 publications

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“…8 No adjuvant chemotherapy is currently recommended 1 although chemotherapy has been tried in some cases that were not surgically resectable with varying response. 9,10,11 . Two cases of MNTI managed successfully with surgical excision alone are presented here.…”

Section: Introductionmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy (progonoma) treated by radical maxillary surgery

Renner

Abdulai²

2010

Ghana Medical Journal

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Section: Introductionmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy (progonoma) treated by radical maxillary surgery

Renner

Abdulai²

2010

Ghana Medical Journal

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“…(Chaudhary et al, 2009). The initial description of MNTI was by Krompecher in 1918, who described it as a melanocarcinoma (Atkinson et al, 1989;George et al, 1995;Perry and Dehner, 2003;Neven et al, 2008). A literature search on PUBMED showed 400 reports of MNTI in indexed literature of which 51 lesions arose from the calvarium.…”

Section: Discussionmentioning

confidence: 99%

“…On T1 WI the lesion shows low signal intensity due to melanin; is hyperintense on T2 WI and exhibits bright enhancement on contrast administration (Atkinson et al, 1989;Perry and Dehner, 2003;Suzuki et al, 2007;Jeon et al, 2008). Microscopically MNTIs are characterized by larger polygonal epithelioid cells which are described as melanocytes producing variable deposits of melanin, smaller neuroblast-like round cells and stromal fibroblasts (Atkinson et al, 1989;George et al, 1995;Neven et al, 2008). The MNTI cells are cytokeratin and HMB 45 (human melanoma block) positive and S-100 negative (Butt et al, 2009;Scheller et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…As MNTI histogenesis indicates the presence of neuroblastomalike cells, radical surgery remains the mainstay of treatment with 6 cycles of vincristine, ifosfamide, carboplatin and etoposide (VECI protocol) being tried out in recurrent cases (Perry and Dehner, 2003;Neven et al, 2008). Radiotherapy and combination chemotherapy has been used for inoperable recurrences or margin positive resections (Butt et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Meningeal tumours in the first 2 decades offer a diagnostic challenge due to their wide morphologic spectrum and rarity (Jeon et al, 2008;Butt et al, 2009). They are usually reported in the head and neck region and are described as locally aggressive benign lesions with a high rate of recurrence (Neven et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis

Furtado

Ghosal

Hegde

2012

Journal of Cranio-Maxillofacial Surgery

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Mass Originating From the Maxillary Alveolar Crest in an Infant

Marston

Black

Pambuccian

et al. 2014

JAMA Otolaryngol Head Neck Surg

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An infant presented with a large mass protruding from the right maxillary alveolar ridge. The mass was first noted at 2 months of age and was initially thought to be an odontogenic cyst. The mass expanded rapidly over the next several months and was associated with intermittent increased work of breathing, feeding difficulty, and a 4.5-kg weight loss. Intraoral examination revealed a large, firm, gray mass originating from the right maxillary alveolar ridge (Figure, A). Contrast computed tomographic imaging showed an expansile multilobulated heterogeneously enhancing mass measuring 4.1 × 4.8 × 4.4 cm originating from the right maxillary alveolar ridge with displacement of the floor of the maxillary sinus. Within the mass there was a central "sunburst" representing new bone formation. The patient was initially taken to the operating room for open biopsy. The specimen consisted of small blue cells with a neuroblastic appearance and cuboidal cells with variable melanin pigmentation forming glandlike epithelial structures within a background of dense fibrous stroma (Figure, B and C). Immunohistochemical analysis revealed that both the epithelial and neural components were positive for neuron-specific enolase. The epithelial cells stained positive for cytokeratin AE1/AE3 (Figure, D), tyrosinase, and S-100, while the neuroblastic cells stained positive for synaptophysin with 20% Ki-67 positivity. The patient's urinary vanillylmandelic acid levels were within reference range.

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Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy

Cited by 59 publications

References 7 publications

Melanotic neuroectodermal tumour of infancy (progonoma) treated by radical maxillary surgery

Melanotic neuroectodermal tumour of infancy (progonoma) treated by radical maxillary surgery

Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis

Mass Originating From the Maxillary Alveolar Crest in an Infant

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