Recurrent lymphadenopathy in children with Kikuchi-Fujimoto disease

Yoo, In Hyuk; Na, Hyunju; Bae, Eun Young; Han, Seung Beom; Lee, Soo Young; Jeong, Dae Chul; Kang, Jin Han

doi:10.1007/s00431-014-2306-6

Cited by 27 publications

(42 citation statements)

References 18 publications

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“…KFD has a reported recurrence rate of 3–4% in adults, while studies in children with KFD have shown high recurrence rates of up to 42.4% . None of the patients in the case series by Lin et al .…”

Section: Discussionmentioning

confidence: 93%

“…6 Paediatric studies have shown a higher recurrence rate of up to 42.4%. 5,[7][8][9][10][11][12] There have also been reports of progression to SLE. 1,[13][14][15] The primary aim of this study was to investigate the clinical characteristics of children with KFD and to assess the recurrence of this disease.…”

Section: What This Paper Addsmentioning

confidence: 99%

“…KFD has a reported recurrence rate of 3–4% . Paediatric studies have shown a higher recurrence rate of up to 42.4% . There have also been reports of progression to SLE …”

mentioning

confidence: 99%

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Kikuchi‐Fujimoto disease in children

Selvanathan

Suhumaran

Sahu

et al. 2019

J Paediatrics Child Health

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Aim Kikuchi‐Fujimoto disease (KFD) is an important cause of lymphadenitis in children. The primary aim of this study was to investigate the clinical characteristics of children with KFD and to assess the recurrence of this disease. Methods This is a retrospective study of patients younger than 18 years old, who were diagnosed with KFD from January 2000 to September 2017 at KK Women's and Children's Hospital. Records of children with a histological diagnosis of KFD from a lymph node biopsy were obtained from the Department of Pathology. Case notes and electronic medical records of the patients were reviewed. Data collected included patient characteristics, symptoms, clinical and laboratory findings, treatment and follow‐up. Results A total of 98 patients were identified. There were 52 boys and 46 girls with a median age of 11.2 years old. Recurrence occurred in 12 (12.2%) patients. One patient developed systemic lupus erythematosus 10 years after diagnosis of KFD. Recurrent cases were more likely to be managed as an inpatient and have fever at presentation of their first episode of KFD. Conclusion In our study, KFD in children had a higher prevalence among boys, and had a recurrence rate of 12.2%, with 1% of patients developing systemic lupus erythematosus. We recommend that patients be followed up for recurrence and advised to monitor for symptoms of recurrence.

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Section: Discussionmentioning

confidence: 93%

Section: What This Paper Addsmentioning

confidence: 99%

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Kikuchi‐Fujimoto disease in children

Selvanathan

Suhumaran

Sahu

et al. 2019

J Paediatrics Child Health

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“…Further evaluation of these relationships, however, is necessary. To the best of our knowledge, all seven previously reported cases of KD associated with HT occurred in females between the ages of 17 and 30 [1-4]. Three of these patients were diagnosed with HT before an episode of KD, whereas four patients were diagnosed with concurrent HT and KD.…”

mentioning

confidence: 99%

“…The etiology of KD remains controversial, but autoimmune disorders including systemic lupus erythematous, tend to develop before, simultaneously, or after an episode of KD [2]. However, only a few KD cases have been reported with autoimmune thyroiditis [1-4]. Here, we report a case of a male patient with concurrent Hashimoto’s thyroiditis (HT) and KD.…”

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confidence: 99%

Sporadic medullary microcarcinoma in a male patient with concurrent Hashimoto’s hypothyroidism and Kikuchi disease

Choi

Yoo

Kim

2016

Korean J Intern Med

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Kikuchi–Fujimoto disease associated with the central nervous system in children

Huang

Wang

et al. 2023

Pediatric Discovery

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The clinical data of patients with Kikuchi–Fujimoto disease (KFD) combined with the involvement of the central system is limited, particularly for children. This study aimed to investigate the clinical features and prognosis of KFD associated with the central nervous system in children. We collected the clinical data of patients diagnosed with KFD combined with the involvement of the central system, hospitalized at Children's Hospital of Chongqing Medical University (CHCMU). Furthermore, we summarized the clinical features and outcomes in children by reviewing the published literature. Together with the two patients from CHMCU enrolled in this study, we identified 19 children diagnosed with KFD combined with the involvement of the central nervous system, including eight males and 11 females. The onset age ranges from 6 to 18 years (the median age was 14 and the interquartile range was 9–16). Sixteen patients were diagnosed with aseptic meningitis. Headache (78.9%, 15/19) was the most common symptom. Cerebrospinal fluid pressure was increased in 3 patients (60.0%, 3/5), cell count was elevated in 14 patients (73.7%, 14/19), glucose was decreased in 4 patients (21.0%, 4/19), and protein was elevated in 12 patients (63.1%, 12/19). A total of 9 patients had cranial imaging changes. Electroencephalogram (EEG) was performed on seven patients and 4 patients presented abnormal EEG (57.1%, 4/7). A total of 12 patients received steroid therapy; two were combined with antiepileptic treatment. In children, KFD complicated with the involvement of the central nervous system was rare and aseptic meningitis was the primary manifestation. Most patients had a good prognosis and a few had residual sequelae of neurological damage.

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Recurrent lymphadenopathy in children with Kikuchi-Fujimoto disease

Abstract: Our results suggest that recurrent KFD is more frequent than reported, and recurrent KFD should be considered in children with a history of other systemic illnesses such as immune disorders.

Cited by 27 publications

References 18 publications

Kikuchi‐Fujimoto disease in children

Kikuchi‐Fujimoto disease in children

Sporadic medullary microcarcinoma in a male patient with concurrent Hashimoto’s hypothyroidism and Kikuchi disease

Kikuchi–Fujimoto disease associated with the central nervous system in children

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