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Cited by 10 publications
(11 citation statements)
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“…Studies comparing KS patients with body mass index and age‐matched controls showed a significantly higher prevalence of diabetes and metabolic syndrome among KS patients (Radicioni et al ., ; Groth et al ., ). Interestingly, the increased prevalence of metabolic syndrome in KS was independent from the normal testosterone levels obtained during adequate replacement therapy, suggesting its independency by the hormonal milieu (Spier et al ., ). In this study only two KS subjects of 23 (8.7%) met the criteria for the diagnosis of metabolic syndrome.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…Studies comparing KS patients with body mass index and age‐matched controls showed a significantly higher prevalence of diabetes and metabolic syndrome among KS patients (Radicioni et al ., ; Groth et al ., ). Interestingly, the increased prevalence of metabolic syndrome in KS was independent from the normal testosterone levels obtained during adequate replacement therapy, suggesting its independency by the hormonal milieu (Spier et al ., ). In this study only two KS subjects of 23 (8.7%) met the criteria for the diagnosis of metabolic syndrome.…”
Section: Discussionmentioning
confidence: 97%
“…Abnormalities in coagulation and fibrinolysis pathways, such as high levels of PAI‐1 activity and increased factor VIII coagulant activity may also be found in KS patients (Veraart et al ., ; Zollner et al ., ). Some recent data suggested that PAI‐1 was differentially expressed between KS patients and male controls (Zitzmann et al ., ) and that increased levels of PAI‐1 seems to be associated with low levels of testosterone and with the presence of leg ulceration in KS patients (Spier et al ., ; Zollner et al ., ; Igawa & Nishioka, ). However, a global assessment of the hemostatic balance is currently lacking in KS patients and a thromboelastometric evaluation could help address this issue.…”
Section: Discussionmentioning
confidence: 97%
“…11 Supplemental androgen may even be a sufficient adjuvant therapy for the treatment of chronic wounds in patients with KS. 14,15 However, in male abusers of anabolic steroids, the net effect on the hemostatic system may paradoxically change from anti-to prothrombotic. It was suggested that an individual threshold dose, above which has thrombogenic effects on platelets and vasomotion, may overcome the profibrinolytic effects on PAI 1.…”
Section: Discussionmentioning
confidence: 99%
“…10 Therefore, the underlying problem of thromboembolism seems to be associated with the androgen deficiency, and supplemental androgen therapy may be a sufficient adjuvant strategy in the long term, even of chronic wounds in patients with Klinefelter's syndrome. [11][12][13] To the best of our knowledge, until now no investigations of the association of Klinefelter's syndrome and elevated factor VIII:C activity were reported. The gene encoding for factor VIII is located near the terminus of the long arm of the X chromosome.…”
Section: Discussionmentioning
confidence: 99%