Recurrent inflammatory myofibroblastic tumor of the inguinal region: A case report and review of the literature

Abstract

Inflammatory myofibroblastic tumors (IMTs) of the inguinal region are exceptionally rare. The current study reported the case of a 49 year-old male patient with IMT, who presented with a fever, night sweats, anorexia, loss of weight and frequent urination. Computed tomography (CT) revealed a lesion occupying the soft tissue of the right inguinal region and surgery was performed to resect the lesion. Histopathological analysis of the lesion revealed a composition of spindle and inflammatory cells, including plasma cells and lymphocytes. In addition, immunohistochemical analysis demonstrated that the tumor cells were positive for CD34, vimentin, actin, Ki-67, B cell lymphoma-2, CD99, epithelial membrane antigen and CD38; however, tumor cells were negative for CD117, desmin, anaplastic lymphoma kinase and creatine kinase. Thus, the patient was diagnosed with IMT and was advised to return for regular follow-up appointments. Subsequently, the patient developed a local recurrence 12 months following the initial surgery. Of note, the histopathological characteristics of the recurrent lesions were consistent with those of the initial specimen. Thus, a second surgery was performed, followed by fractionated radiotherapy (FRT). At 3 and 6 months following the FRT, magnetic resonance imaging scans did not indicate tumor recurrence or metastasis. In conclusion, surgical excision is the current recommended treatment for IMT; however, for cases similar to that of the current study, which are not successfully controlled by surgical excision, radiotherapy should be considered and long-term follow-up is essential.

Inflammatory myofibroblastic tumor of the spermatic cord: two cases and review of the literature

“…18,19 Chemotherapy and/or radiotherapy should be considered in patients whose surgical resection is incomplete, in those with postoperative recurrences, and in those with evidence of malignant (or "sarcomatoid") transformation that can be identified histologically. 16,20 In our cases, we did not give any additional treatment. Cases reported in the literature are summarized in Table 1.…”

Polypoid Carcinoma of the Oropharynx with Stromal Ossifying Myofibroblastic Proliferation: A Case Report and Literature Review

“…These lesions most often occur in the genitourinary system (bladder, prostate, ureter, vagina, and vulva) [24–26] but can occasionally arise in the gastrointestinal tract [27, 28] or in the organs of the upper aerodigestive tract (pharynx, larynx, nasal cavities, and mouth) [29, 30]. They should be clearly distinguished from the inflammatory myofibroblastic tumor (IMT) [31, 32], and for this reason the confusing adjective inflammatory should be avoided in their description.…”

Inflammatory myofibroblastic tumor of the lumbar spinal canal

“…[2] Most patients with an IMT are younger than 16 years of age. [3] An IMT can arise in multiple anatomic locations, with the most common sites being the lungs and omentum.…”